Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application

Dell’Anno, Filippo; Vitale, Giovanni Andrea; Buonocore, Carmine; Vitale, Laura; Palma Esposito, Fortunato; Coppola, Daniela; Della Sala, Gerardo; Tedesco, Pietro; de Pascale, Donatella

doi:10.3390/ijms231911507

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Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application

by

Filippo Dell’Anno

,

Giovanni Andrea Vitale

,

Carmine Buonocore

,

Laura Vitale

,

Fortunato Palma Esposito

,

Daniela Coppola

,

Gerardo Della Sala

,

Pietro Tedesco

^*

and

Donatella de Pascale

^*

Department of Eco-Sustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via Ammiraglio Ferdinando Acton 55, 80133 Naples, Italy

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2022, 23(19), 11507; https://doi.org/10.3390/ijms231911507

Submission received: 9 September 2022 / Revised: 20 September 2022 / Accepted: 23 September 2022 / Published: 29 September 2022

(This article belongs to the Special Issue Bioactive Natural Products: Isolation, Structural Elucidation and Biological Assays)

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Abstract

Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron necessary for cell metabolism. Moreover, PVDs also play a crucial role in microbes’ survival by mediating biofilm formation and virulence. In this review, we reorganize the information produced in recent years regarding PVDs biosynthesis and pathogenic mechanisms, since PVDs are extremely valuable compounds. Additionally, we summarize the therapeutic applications deriving from the PVDs’ use and focus on their role as therapeutic target themselves. We assess the current biotechnological applications of different sectors and evaluate the state-of-the-art technology relating to the use of synthetic biology tools for pathway engineering. Finally, we review the most recent methods and techniques capable of identifying such molecules in complex matrices for drug-discovery purposes.

Keywords: pyoverdine; siderophore; iron; Pseudomonas sp.; mass spectrometry

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MDPI and ACS Style

Dell’Anno, F.; Vitale, G.A.; Buonocore, C.; Vitale, L.; Palma Esposito, F.; Coppola, D.; Della Sala, G.; Tedesco, P.; de Pascale, D. Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application. Int. J. Mol. Sci. 2022, 23, 11507. https://doi.org/10.3390/ijms231911507

AMA Style

Dell’Anno F, Vitale GA, Buonocore C, Vitale L, Palma Esposito F, Coppola D, Della Sala G, Tedesco P, de Pascale D. Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application. International Journal of Molecular Sciences. 2022; 23(19):11507. https://doi.org/10.3390/ijms231911507

Chicago/Turabian Style

Dell’Anno, Filippo, Giovanni Andrea Vitale, Carmine Buonocore, Laura Vitale, Fortunato Palma Esposito, Daniela Coppola, Gerardo Della Sala, Pietro Tedesco, and Donatella de Pascale. 2022. "Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application" International Journal of Molecular Sciences 23, no. 19: 11507. https://doi.org/10.3390/ijms231911507

APA Style

Dell’Anno, F., Vitale, G. A., Buonocore, C., Vitale, L., Palma Esposito, F., Coppola, D., Della Sala, G., Tedesco, P., & de Pascale, D. (2022). Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application. International Journal of Molecular Sciences, 23(19), 11507. https://doi.org/10.3390/ijms231911507

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Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application

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