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Article

Osteoclast-Driven Osteogenesis, Bone Remodeling and Biomaterial Resorption: A New Profile of BMP2-CPC-Induced Alveolar Bone Regeneration

by
Hongzhou Shen
1,†,
Yu Zhuang
1,2,†,
Chenglong Zhang
1,2,
Changru Zhang
3,
Yuan Yuan
3,
Hongbo Yu
1,*,
Jiawen Si
1,* and
Guofang Shen
1
1
Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
2
Laboratory for Digitized Stomatology, Research Center for Craniofacial Anomalies, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China
3
Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(20), 12204; https://doi.org/10.3390/ijms232012204
Submission received: 2 September 2022 / Revised: 1 October 2022 / Accepted: 8 October 2022 / Published: 13 October 2022
(This article belongs to the Special Issue Functional Porous Materials – Relationship between Structure and Properties)
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Abstract

This bedside-to-bench study aimed to systematically investigate the value of applying BMP2-loaded calcium phosphate cement (BMP2-CPC) in the restoration of large-scale alveolar bone defects. Compared to deproteinized bovine bone (DBB), BMP2-CPC was shown to be capable of inducing a favorable pattern of bone regeneration and bone remodeling accompanied by active osteoclastogenesis and optimized biomaterial resorption when applied in reconstructive periodontally accelerated osteogenic orthodontics (PAOO) surgery. To verify the regulatory role of osteoclasts in the BMP2-CPC-induced pattern of bone regeneration, in vitro and in vivo studies were designed to elucidate the underlying mechanism. Our results revealed that osteoclasts played a multifaceted role (facilitating osteogenesis, bone remodeling and biomaterial resorption) in the BMP2-CPC-induced bone regeneration. Osteoclasts contributed to the osteogenic differentiation of mesenchymal stem cells (MSCs) by secreting calcium ions, CTHRC1 and PDGF-B. Moreover, the increased osteoclasts promoted the remodeling of new bone and BMP2-CPC resorption, leading to a harmonized replacement of biomaterials with mature bone. In conclusion, the in vitro and in vivo experimental results corresponded with the clinical results and showed the optimized properties of BMP2-CPC in activating osteoclast-driven bone regeneration and remodeling, thus indicating the highly promising prospects of BMP2-CPC as an ideal therapeutic for alveolar bone defects.
Keywords: osteoclasts; alveolar bone regeneration; bone remodeling; biomaterial resorption; calcium phosphate cement osteoclasts; alveolar bone regeneration; bone remodeling; biomaterial resorption; calcium phosphate cement

Share and Cite

MDPI and ACS Style

Shen, H.; Zhuang, Y.; Zhang, C.; Zhang, C.; Yuan, Y.; Yu, H.; Si, J.; Shen, G. Osteoclast-Driven Osteogenesis, Bone Remodeling and Biomaterial Resorption: A New Profile of BMP2-CPC-Induced Alveolar Bone Regeneration. Int. J. Mol. Sci. 2022, 23, 12204. https://doi.org/10.3390/ijms232012204

AMA Style

Shen H, Zhuang Y, Zhang C, Zhang C, Yuan Y, Yu H, Si J, Shen G. Osteoclast-Driven Osteogenesis, Bone Remodeling and Biomaterial Resorption: A New Profile of BMP2-CPC-Induced Alveolar Bone Regeneration. International Journal of Molecular Sciences. 2022; 23(20):12204. https://doi.org/10.3390/ijms232012204

Chicago/Turabian Style

Shen, Hongzhou, Yu Zhuang, Chenglong Zhang, Changru Zhang, Yuan Yuan, Hongbo Yu, Jiawen Si, and Guofang Shen. 2022. "Osteoclast-Driven Osteogenesis, Bone Remodeling and Biomaterial Resorption: A New Profile of BMP2-CPC-Induced Alveolar Bone Regeneration" International Journal of Molecular Sciences 23, no. 20: 12204. https://doi.org/10.3390/ijms232012204

APA Style

Shen, H., Zhuang, Y., Zhang, C., Zhang, C., Yuan, Y., Yu, H., Si, J., & Shen, G. (2022). Osteoclast-Driven Osteogenesis, Bone Remodeling and Biomaterial Resorption: A New Profile of BMP2-CPC-Induced Alveolar Bone Regeneration. International Journal of Molecular Sciences, 23(20), 12204. https://doi.org/10.3390/ijms232012204

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