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Volume 23
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10.3390/ijms232112732
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Review

Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability

by
Hongji Wang
1,
Chaowen Zhang
1,
Mengnan Li
1,2,
Chaoran Liu
1,2,
Jingyi Wang
1,
Xuan Ou
1 and
Yuzhu Han
1,2,*
1
College of Animal Science and Technology, Southwest University, Chongqing 402460, China
2
Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(21), 12732; https://doi.org/10.3390/ijms232112732
Submission received: 22 August 2022 / Revised: 19 October 2022 / Accepted: 19 October 2022 / Published: 22 October 2022
(This article belongs to the Special Issue Biopolymer Composites 2022)
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Abstract

Changes in mitochondrial membrane permeability are closely associated with mitochondria-mediated apoptosis. Antimicrobial peptides (AMPs), which have been found to enter cells to exert physiological effects, cause damage to the mitochondria. This paper reviews the molecular mechanisms of AMP-mediated apoptosis by changing the permeability of the mitochondrial membrane through three pathways: the outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), and mitochondrial permeability transition pore (MPTP). The roles of AMPs in inducing changes in membrane permeability and apoptosis are also discussed. Combined with recent research results, the possible application prospects of AMPs are proposed to provide a theoretical reference for the development of AMPs as therapeutic agents for human diseases.
Keywords: AMPs; mitochondrial outer membrane permeability (MOMP); mitochondrial inner membrane permeability (MIMP); mitochondrial permeability transition (MPT); apoptosis AMPs; mitochondrial outer membrane permeability (MOMP); mitochondrial inner membrane permeability (MIMP); mitochondrial permeability transition (MPT); apoptosis
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MDPI and ACS Style

Wang, H.; Zhang, C.; Li, M.; Liu, C.; Wang, J.; Ou, X.; Han, Y. Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability. Int. J. Mol. Sci. 2022, 23, 12732. https://doi.org/10.3390/ijms232112732

AMA Style

Wang H, Zhang C, Li M, Liu C, Wang J, Ou X, Han Y. Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability. International Journal of Molecular Sciences. 2022; 23(21):12732. https://doi.org/10.3390/ijms232112732

Chicago/Turabian Style

Wang, Hongji, Chaowen Zhang, Mengnan Li, Chaoran Liu, Jingyi Wang, Xuan Ou, and Yuzhu Han. 2022. "Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability" International Journal of Molecular Sciences 23, no. 21: 12732. https://doi.org/10.3390/ijms232112732

APA Style

Wang, H., Zhang, C., Li, M., Liu, C., Wang, J., Ou, X., & Han, Y. (2022). Antimicrobial Peptides Mediate Apoptosis by Changing Mitochondrial Membrane Permeability. International Journal of Molecular Sciences, 23(21), 12732. https://doi.org/10.3390/ijms232112732

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