Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics
Abstract
:1. Introduction
2. Results
2.1. NMR Spectra of CDX Mice Brain and Liver Extracts
2.2. Effect of cDDP and Pd2Spm on CDX Mice Brain Profiling
2.3. Effect of cDDP and Pd2Spm on CDX Mice Liver Profiling
2.4. Intra- and Inter-Organ Correlations for Brain and Liver Polar Profiles
3. Discussion
3.1. Metabolic Impact of Drugs on the Brain
3.2. Metabolic Impact of Drugs on the Liver
3.3. Inter-Organ Metabolic Relationships within the Liver-Brain Axis
4. Materials and Methods
4.1. Ethical Considerations and Animal Procedures
4.2. Drugs Administration and Tissue Collection
4.3. Brain and Liver Extraction
4.4. NMR Spectroscopy
4.5. Data Processing and Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
References
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Carneiro, T.J.; Vojtek, M.; Gonçalves-Monteiro, S.; Batista de Carvalho, A.L.M.; Marques, M.P.M.; Diniz, C.; Gil, A.M. Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics. Int. J. Mol. Sci. 2022, 23, 13773. https://doi.org/10.3390/ijms232213773
Carneiro TJ, Vojtek M, Gonçalves-Monteiro S, Batista de Carvalho ALM, Marques MPM, Diniz C, Gil AM. Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics. International Journal of Molecular Sciences. 2022; 23(22):13773. https://doi.org/10.3390/ijms232213773
Chicago/Turabian StyleCarneiro, Tatiana J., Martin Vojtek, Salomé Gonçalves-Monteiro, Ana L. M. Batista de Carvalho, Maria Paula M. Marques, Carmen Diniz, and Ana M. Gil. 2022. "Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics" International Journal of Molecular Sciences 23, no. 22: 13773. https://doi.org/10.3390/ijms232213773