The Histamine H4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H3 Receptor Antagonist GSK189254
Abstract
:1. Introduction
2. Results
2.1. GSK189254 Attenuates Pain Hypersensitivity in SNI Mice through H4R Activation
2.2. Lack of Contribution of H4R to the Anorexiant Effect of GSK 189254
2.3. Lack of Locomotor Side Effects
3. Discussion
4. Materials and Methods
4.1. Drugs
4.2. Experimental Design
4.3. Animals
4.4. Microinjection into the Locus Coeruleus
4.5. Intrathecal Injection
4.6. Spared Nerve Injury (SNI)
4.7. Nociceptive Behaviour
4.7.1. Von Frey Test
4.7.2. Hargreaves’ Plantar Test
4.8. Locomotor Activity
4.8.1. Rotarod Test
4.8.2. Hole-Board Test
4.9. Evaluation of Food Consumption
4.10. Immunofluorescence
4.11. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Borgonetti, V.; Galeotti, N. The Histamine H4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H3 Receptor Antagonist GSK189254. Int. J. Mol. Sci. 2022, 23, 14314. https://doi.org/10.3390/ijms232214314
Borgonetti V, Galeotti N. The Histamine H4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H3 Receptor Antagonist GSK189254. International Journal of Molecular Sciences. 2022; 23(22):14314. https://doi.org/10.3390/ijms232214314
Chicago/Turabian StyleBorgonetti, Vittoria, and Nicoletta Galeotti. 2022. "The Histamine H4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H3 Receptor Antagonist GSK189254" International Journal of Molecular Sciences 23, no. 22: 14314. https://doi.org/10.3390/ijms232214314
APA StyleBorgonetti, V., & Galeotti, N. (2022). The Histamine H4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H3 Receptor Antagonist GSK189254. International Journal of Molecular Sciences, 23(22), 14314. https://doi.org/10.3390/ijms232214314