Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders
Abstract
:1. Introduction
1.1. How the Tight Junctions “Break Down”, Resulting in Diseases
1.2. Redox Systems That Affect TJ
1.3. Permeability Barrier Related to Tight Junction Structure
2. Redox Regulation of the Permeability Barrier and Associated Disorders
3. Role of Metabolism in Intestinal Homeostasis and the Pentose Phosphate Pathway (PPP) as a Therapeutic Target
4. Models of Intestinal Barrier Dysfunction and Associated Disorders
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Agents | Model | Findings | Reference |
---|---|---|---|
Alcohol | Caco-2 cells mice |
| [8] |
Hydrogen peroxide | Caco-2 and MDCK monolayer cells |
| [9,10] |
particulate matter | Caco-2 cells |
| [11] |
particulate matter | Caco-2 cells C57BL/6 mice |
| [12] |
Pro-inflammatory cytokines | Caco-2 cells |
| [13] |
Xanthine oxidase and xanthine | Caco-2 cells |
| [14,15] |
Agents | Model | Findings | Reference |
---|---|---|---|
Butyrate | Colonocytes |
| [62,63,64] |
Cyba (p22phox) | Mouse |
| [19] |
Glucagon-like peptide-2 (GLP-2) | Caco-2 cells |
| [69] |
Glutamine, Arginine | Caco-2 cells |
| [67] |
Glutamine | Sprague Dawley rats |
| [68] |
Hypoxia Inducing Factor (HIF) | T84, 293T and colon epithelial cells |
| [70,71] |
HIF hydroxylase inhibitors or HIF-1α stabilizer | murine models |
| [72,73,74,75] |
IL-10 gene | Mouse |
| [76,77] |
JAM-A | Mouse |
| [78] |
NO donors (NOC5, NOC12) | Caco-2 cells |
| [9] |
NAC | Mouse intestinal crypt culture |
| [79] |
Pyruvate | Mice |
| [57] |
Qucertin | Caco-2 cells |
| [80] |
Quercetin nanoparticles | Wistar rats |
| [81] |
Sphingolipids (Ceramide, sphigosine-1-phosphate) | Clinical data |
| [58,59,60] |
Tryptophan | Clinical data |
| [65] |
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Lin, P.-Y.; Stern, A.; Peng, H.-H.; Chen, J.-H.; Yang, H.-C. Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders. Int. J. Mol. Sci. 2022, 23, 14463. https://doi.org/10.3390/ijms232214463
Lin P-Y, Stern A, Peng H-H, Chen J-H, Yang H-C. Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders. International Journal of Molecular Sciences. 2022; 23(22):14463. https://doi.org/10.3390/ijms232214463
Chicago/Turabian StyleLin, Pei-Yun, Arnold Stern, Hsin-Hsin Peng, Jiun-Han Chen, and Hung-Chi Yang. 2022. "Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders" International Journal of Molecular Sciences 23, no. 22: 14463. https://doi.org/10.3390/ijms232214463