Cytotoxic and Anti-Inflammatory Triterpenoids in the Vines and Leaves of Momordica charantia
Abstract
:1. Introduction
2. Results
2.1. Cucurbitane-Type Triterpenoids Isolated from the Vines and Leaves of M. charantia
2.2. Cytotoxicity of Triterpenoids
2.3. Anti-Inflammatory Effects of Triterpenoids
2.4. Anti-Inflammatory Mechanism of TCD
3. Discussion
4. Materials and Methods
4.1. Chemicals and Reagents
4.2. General Experimental Procedures
4.3. Plant Materials
4.4. Extraction and Isolation of Triterpenoids
4.5. Cell Culture and Cytotoxicity Assays
4.6. Western Blotting
4.7. Phagocytosis Analysis
4.8. Analysis of NO and Cytokines
4.9. Animal Experiments
4.10. Confocal Microscopy
4.11. Statistical Analysis
4.12. LogP Calculation
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Chou, M.-C.; Lee, Y.-J.; Wang, Y.-T.; Cheng, S.-Y.; Cheng, H.-L. Cytotoxic and Anti-Inflammatory Triterpenoids in the Vines and Leaves of Momordica charantia. Int. J. Mol. Sci. 2022, 23, 1071. https://doi.org/10.3390/ijms23031071
Chou M-C, Lee Y-J, Wang Y-T, Cheng S-Y, Cheng H-L. Cytotoxic and Anti-Inflammatory Triterpenoids in the Vines and Leaves of Momordica charantia. International Journal of Molecular Sciences. 2022; 23(3):1071. https://doi.org/10.3390/ijms23031071
Chicago/Turabian StyleChou, Mei-Chia, Yuan-Jia Lee, Yao-Ting Wang, Shi-Yie Cheng, and Hsueh-Ling Cheng. 2022. "Cytotoxic and Anti-Inflammatory Triterpenoids in the Vines and Leaves of Momordica charantia" International Journal of Molecular Sciences 23, no. 3: 1071. https://doi.org/10.3390/ijms23031071