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Review

Cancer as a Metabolic Disorder

1
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Veritas Hall D 306, 85 Songdogwahak-ro, Incheon 21983, Korea
2
Department of Medical Laboratory Sciences, University of Health and Allied Sciences, PMB 31, Ho, Ghana
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(3), 1155; https://doi.org/10.3390/ijms23031155
Submission received: 5 January 2022 / Revised: 19 January 2022 / Accepted: 19 January 2022 / Published: 21 January 2022
(This article belongs to the Special Issue Advances in Cancer Metabolism and Tumour Microenvironment 2.0)

Abstract

Cancer has long been considered a genetic disease characterized by a myriad of mutations that drive cancer progression. Recent accumulating evidence indicates that the dysregulated metabolism in cancer cells is more than a hallmark of cancer but may be the underlying cause of the tumor. Most of the well-characterized oncogenes or tumor suppressor genes function to sustain the altered metabolic state in cancer. Here, we review evidence supporting the altered metabolic state in cancer including key alterations in glucose, glutamine, and fatty acid metabolism. Unlike genetic alterations that do not occur in all cancer types, metabolic alterations are more common among cancer subtypes and across cancers. Recognizing cancer as a metabolic disorder could unravel key diagnostic and treatments markers that can impact approaches used in cancer management.
Keywords: cancer; metabolism; glucose; glutamine; fatty acids cancer; metabolism; glucose; glutamine; fatty acids

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MDPI and ACS Style

Gyamfi, J.; Kim, J.; Choi, J. Cancer as a Metabolic Disorder. Int. J. Mol. Sci. 2022, 23, 1155. https://doi.org/10.3390/ijms23031155

AMA Style

Gyamfi J, Kim J, Choi J. Cancer as a Metabolic Disorder. International Journal of Molecular Sciences. 2022; 23(3):1155. https://doi.org/10.3390/ijms23031155

Chicago/Turabian Style

Gyamfi, Jones, Jinyoung Kim, and Junjeong Choi. 2022. "Cancer as a Metabolic Disorder" International Journal of Molecular Sciences 23, no. 3: 1155. https://doi.org/10.3390/ijms23031155

APA Style

Gyamfi, J., Kim, J., & Choi, J. (2022). Cancer as a Metabolic Disorder. International Journal of Molecular Sciences, 23(3), 1155. https://doi.org/10.3390/ijms23031155

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