Heart Failure after Cardiac Surgery: The Role of Halogenated Agents, Myocardial Conditioning and Oxidative Stress

Round 1

Reviewer 1 Report

This manuscript will need to revise a few points.

1 Introduction

I didn't understand the hypothesis of this study. Please specify your hypothesis. 

 

2.Study design and results

I think that the reproducibility of this study needs to be clearly stated. If it cannot be stated, it should be stated as the limit of research. 

3. There is a lot of literature consideration about the discussion. Please consider based on this result. Minimize citations in the literature. 

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

The present review by Guerrero-Orriach, Carmona Luque and Gonzales Alvarez focuses on the impact of halogenated agents on cardiac dysfunction and report various mechanisms of pre- and postconditioning as well as their personal experience. 

The study is well written and supports the current existing data situation. 

I have the following comments: 

1. It is not made clear if your review is pointed to patients undergoing myocardial revascularization surgery or cardiac surgery in general. Please specify in the introduction section.
2. The review mentions positive results on the mortality, however it is not made clear, if this especially applies to short- or long-term-mortality, if seen fit I would suggest clarifying. 
3. Consider also citing the meta-analysis "Volatile Anesthetics versus Propofol for Cardiac Surgery with Cardiopulmonary Bypass: Meta-analysis of Randomized Trials" since the results very much seem to be in line with your review. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

The manuscript is suitable for publication, while the Authors should be commended for their work.

Author Response

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Author Response File: Author Response.pdf