Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin
Abstract
:1. Introduction
2. Results and Discussion
2.1. Clinically Relevant Doses of Desmopressin Loaded in Nanofiber–Film Hybrid System
2.2. Nanofiber–Film Hybrid System Ensures Controlled and Unidirectional Release of Desmopressin
2.3. Nanofiber–Film Hybrid System Protects Peptide from Wash-Out
3. Materials and Methods
3.1. Materials
3.2. Electrospinning of Chitosan/PEO Nanofibers with Desmopressin
3.3. Preparation of Nanofiber–Film Hybrid System
3.4. Visualization of Nanofiber Morphology by Scanning Electron Microscopy
3.5. Release of Desmopressin from Fiber–Film Hybrid System in Ussing Chambers
3.6. Ex Vivo Flow Retention Model
3.7. Quantification of Desmopressin by HPLC-UV
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Stie, M.B.; Gätke, J.R.; Chronakis, I.S.; Jacobsen, J.; Nielsen, H.M. Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin. Int. J. Mol. Sci. 2022, 23, 1458. https://doi.org/10.3390/ijms23031458
Stie MB, Gätke JR, Chronakis IS, Jacobsen J, Nielsen HM. Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin. International Journal of Molecular Sciences. 2022; 23(3):1458. https://doi.org/10.3390/ijms23031458
Chicago/Turabian StyleStie, Mai Bay, Johan Ring Gätke, Ioannis S. Chronakis, Jette Jacobsen, and Hanne Mørck Nielsen. 2022. "Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin" International Journal of Molecular Sciences 23, no. 3: 1458. https://doi.org/10.3390/ijms23031458