Next Article in Journal
MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration
Next Article in Special Issue
Diet–Microbiota Interplay: An Emerging Player in Macrophage Plasticity and Intestinal Health
Previous Article in Journal
Incorporation of a FRET Pair into a Riboswitch RNA to Measure Mg2+ Concentration and RNA Conformational Change in Cell
Previous Article in Special Issue
Synbiotics Alleviate Hepatic Damage, Intestinal Injury and Muscular Beclin-1 Elevation in Rats after Chronic Ethanol Administration
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 3
10.3390/ijms23031494
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?

by
Luciano C. Ramires
1,
Gabriel Silva Santos
2,*,
Rafaela Pereira Ramires
3,
Lucas Furtado da Fonseca
4,*,
Madhan Jeyaraman
5,
Sathish Muthu
6,
Anna Vitória Lana
7,
Gabriel Azzini
2,
Curtis Scott Smith
8 and
José Fábio Lana
2
1
Department of Orthopaedics and Sports Medicine, Mãe de Deus Hospital, Porto Alegre 90110-270, RS, Brazil
2
Department of Orthopaedics, The Bone and Cartilage Institute, Indaiatuba 13334-170, SP, Brazil
3
Department of Biology, Cellular, Molecular and Biomedical Science, Boise State University, 1910 W University Drive, Boise, ID 83725, USA
4
Department of Orthopaedics, The Federal University of São Paulo, São Paulo 04024-002, SP, Brazil
5
Department of Orthopaedics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600095, Tamil Nadu, India
6
Department of Orthopaedics, Government Medical College and Hospital, Dindigul 624304, Tamil Nadu, India
7
Department of Medicine, Max Planck University Center, Indaiatuba 13343-060, SP, Brazil
8
Department of Medicine, University of Washington School of Medicine, Seattle, WA 83703, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(3), 1494; https://doi.org/10.3390/ijms23031494
Submission received: 18 November 2021 / Revised: 11 January 2022 / Accepted: 25 January 2022 / Published: 27 January 2022
(This article belongs to the Special Issue Diet-Microbiota and Host Interactions in Intestinal Health and Inflammation 2.0)
Browse Figures
Versions Notes

Abstract

Some say that all diseases begin in the gut. Interestingly, this concept is actually quite old, since it is attributed to the Ancient Greek physician Hippocrates, who proposed the hypothesis nearly 2500 years ago. The continuous breakthroughs in modern medicine have transformed our classic understanding of the gastrointestinal tract (GIT) and human health. Although the gut microbiota (GMB) has proven to be a core component of human health under standard metabolic conditions, there is now also a strong link connecting the composition and function of the GMB to the development of numerous diseases, especially the ones of musculoskeletal nature. The symbiotic microbes that reside in the gastrointestinal tract are very sensitive to biochemical stimuli and may respond in many different ways depending on the nature of these biological signals. Certain variables such as nutrition and physical modulation can either enhance or disrupt the equilibrium between the various species of gut microbes. In fact, fat-rich diets can cause dysbiosis, which decreases the number of protective bacteria and compromises the integrity of the epithelial barrier in the GIT. Overgrowth of pathogenic microbes then release higher quantities of toxic metabolites into the circulatory system, especially the pro-inflammatory cytokines detected in osteoarthritis (OA), thereby promoting inflammation and the initiation of many disease processes throughout the body. Although many studies link OA with GMB perturbations, further research is still needed.
Keywords: osteoarthritis; gut microbiota; metabolic syndrome; systemic inflammation osteoarthritis; gut microbiota; metabolic syndrome; systemic inflammation

Share and Cite

MDPI and ACS Style

Ramires, L.C.; Santos, G.S.; Ramires, R.P.; da Fonseca, L.F.; Jeyaraman, M.; Muthu, S.; Lana, A.V.; Azzini, G.; Smith, C.S.; Lana, J.F. The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut? Int. J. Mol. Sci. 2022, 23, 1494. https://doi.org/10.3390/ijms23031494

AMA Style

Ramires LC, Santos GS, Ramires RP, da Fonseca LF, Jeyaraman M, Muthu S, Lana AV, Azzini G, Smith CS, Lana JF. The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut? International Journal of Molecular Sciences. 2022; 23(3):1494. https://doi.org/10.3390/ijms23031494

Chicago/Turabian Style

Ramires, Luciano C., Gabriel Silva Santos, Rafaela Pereira Ramires, Lucas Furtado da Fonseca, Madhan Jeyaraman, Sathish Muthu, Anna Vitória Lana, Gabriel Azzini, Curtis Scott Smith, and José Fábio Lana. 2022. "The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut?" International Journal of Molecular Sciences 23, no. 3: 1494. https://doi.org/10.3390/ijms23031494

APA Style

Ramires, L. C., Santos, G. S., Ramires, R. P., da Fonseca, L. F., Jeyaraman, M., Muthu, S., Lana, A. V., Azzini, G., Smith, C. S., & Lana, J. F. (2022). The Association between Gut Microbiota and Osteoarthritis: Does the Disease Begin in the Gut? International Journal of Molecular Sciences, 23(3), 1494. https://doi.org/10.3390/ijms23031494

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop