Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes
Abstract
:1. Introduction
2. Results
2.1. Gata3 Silencing Induces Differentiation and Reduces the Viability of 661W Cells
2.2. The Gata3 Expression Profile in the Developing Mouse Retina Is Generally Similar to That in Precursor-Like Cells
2.3. Exogenous Gata3 Inhibits Synaptophysin (Syn) Expression and Neurite Outgrowth and Reduces the Viability of Primary Retinal Neurocytes in Vitro
2.4. Gata3 Overexpression Impairs Mouse Retinal Function in Vivo
3. Discussion
4. Materials and Methods
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Chen, P.; Wu, Y.; Zhuang, J.; Liu, X.; Luo, Q.; Wang, Q.; Jiang, Z.; He, A.; Chen, S.; Chen, X.; et al. Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes. Int. J. Mol. Sci. 2022, 23, 2495. https://doi.org/10.3390/ijms23052495
Chen P, Wu Y, Zhuang J, Liu X, Luo Q, Wang Q, Jiang Z, He A, Chen S, Chen X, et al. Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes. International Journal of Molecular Sciences. 2022; 23(5):2495. https://doi.org/10.3390/ijms23052495
Chicago/Turabian StyleChen, Pei, Yihui Wu, Jiejie Zhuang, Xuan Liu, Qian Luo, Qiyun Wang, Zihua Jiang, Anqi He, Shuilian Chen, Xi Chen, and et al. 2022. "Gata3 Silencing Is Involved in Neuronal Differentiation and Its Abnormal Expression Impedes Neural Activity in Adult Retinal Neurocytes" International Journal of Molecular Sciences 23, no. 5: 2495. https://doi.org/10.3390/ijms23052495