Homeostasis and Cancer Initiation: Organoids as Models to Study the Initiation of Gastric Cancer
Abstract
:1. The Need to Understand the Complex Factors That Lead to Gastric Cancer
2. Gastric Homeostasis: The Key Role of Adult Stem Cells in the Gastric Gland
Characteristics of Gastric Stem Cells
3. Organoids as a Tool to Study the Role of Host Genetics in Gastric Cancer
4. H. pylori Infection as a Direct Driver of Stem Cell Transformation
5. H. pylori Virulence Factors in Cancer Initiation
5.1. H. pylori Induced DNA Damage
5.2. Chromosomal Change
6. EBV as an Initiator of Gastric Cancer
7. Chronic Inflammation Creates a Milieu Balanced between Injury and Immune Suppression, Creating an Environment in the Stroma That Predisposes to Stem Cell Changes
8. Organoid Cultures as Tools to Study Progression from Metaplasia to Gastric Cancer
Organoids as Tools for Loss of Function Studies
9. The Gastric Microbiota Intersects with the Inflammatory Response and Gastric Homeostasis
10. Conclusions and Future Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Idowu, S.; Bertrand, P.P.; Walduck, A.K. Homeostasis and Cancer Initiation: Organoids as Models to Study the Initiation of Gastric Cancer. Int. J. Mol. Sci. 2022, 23, 2790. https://doi.org/10.3390/ijms23052790
Idowu S, Bertrand PP, Walduck AK. Homeostasis and Cancer Initiation: Organoids as Models to Study the Initiation of Gastric Cancer. International Journal of Molecular Sciences. 2022; 23(5):2790. https://doi.org/10.3390/ijms23052790
Chicago/Turabian StyleIdowu, Sulaimon, Paul P. Bertrand, and Anna K. Walduck. 2022. "Homeostasis and Cancer Initiation: Organoids as Models to Study the Initiation of Gastric Cancer" International Journal of Molecular Sciences 23, no. 5: 2790. https://doi.org/10.3390/ijms23052790