Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases
Abstract
:1. Introduction
2. Glycoside-Phosphorylases
2.1. GP Catalytic Mechanism
2.2. Classification and Substrate Specificity
2.2.1. Retaining GPs
2.2.2. Inverting GPs
2.3. Tertiary and Quaternary Structures
2.4. Biotechnological Applications
2.5. Methods for Glycoside Phosphorylase Activity Detection
2.5.1. Chromogenic Assays
2.5.2. Chromatographic and Spectroscopic Methods for Carbohydrate Detection and Characterization
2.6. Enzyme Discovery by Functional (Meta)Genomics
2.6.1. Activity-Based Approaches
2.6.2. Sequence-Based Approaches
- COG: the protein belongs to COG2152: Predicted glycosyl hydrolase, GH43/DUF377 family (Carbohydrate transport and metabolism). The biochemical characterization of this enzyme [109], indicated that these results are false, this enzyme being a mannoside-phosphorylase of the GH130 family, which does not contain a GH43 module.
- Pfam: the protein contains the domain Glyco_hydro_130 (PF04041), described as ‘beta-1,4-mannooligosaccharide phosphorylase’. This is true, but the same result is found for the GH130 β-1,2-Mannosidase AAO78885.1 [194].
- Kegg: no result.
3. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Family | Mechanism | GenBank Uniprot | Protein Name | Organism | PDB | Reverse-Phosphorolysis Activity | Reference (DOI) | ||
---|---|---|---|---|---|---|---|---|---|
Donor | Acceptor | Product | |||||||
GH3 | Retaining | AUG44408.1 | β-glucoside phosphorylase (BglP) | uncultured bacterium | 5VQD, 5VQE | β-GlcNac1P β-Glc1P | p-NP/DNP | p-Nitrophenyl-N-acetyl-β-d-glucosaminide p-nitrophenyl-β-d-glucopyranoside 2,4-Dinitrophenyl-β- d-glucopyranoside | [30] |
GH3 | Retaining | AAQ05801.1 | Bifunctional N-acetyl-β-glucosaminidase/β-glucosidase (Nag3) | Cellulomonas fimi ATCC 484 | β-Glc1P | DNP | 2,4-Dinitrophenyl-β-d-glucopyranoside | [31] | |
GH13_18 | Retaining | AAO33821.1 | Sucrose phosphorylase (SucP;SP;BaSP) | Bifidobacterium adolescentis DSM 20083 | 1R7A, 2GDU, 2GDV, 5C8B, 5M9X, 5MAN, 5MB2, 6FME | α-Glc1P | d-fructose | Sucrose: (α-d-glucopyranosyl-(1→2)-β-d-fructofuranoside) | [32] |
GH13_18 | Retaining | AAN24362.1 | Sucrose phosphorylase (Spl;BL0536) | Bifidobacterium longum NCC2705 | α-Glc1P | d-fructose | Sucrose | [33] | |
GH13_18 | Retaining | AAO84039.1 | Sucrose phosphorylase (SplP) | Bifidobacterium longum SJ32 | α-Glc1P | d fructose | Sucrose | [34] | |
GH13_18 | Retaining | BAF62433.1 | Sucrose phosphorylase (Spl) | Bifidobacterium longum subsp. longum JCM 1217 | α-Glc1P | d-fructose | Sucrose | [35] | |
GH13_18 | Retaining | AAC74391.2 | Glucosylglycerate phosphorylase (YcjM) | Escherichia coli str. K-12 substr. MG1655 | α-Glc1P | d glycerate | Glucosyl-glycerate | [28] | |
GH13_18 | Retaining | AAO21868.1 | Sucrose phosphorylase (LaSP;GtfA2;LBA1437) | Lactobacillus acidophilus NCFM | α-Glc1P | d fructose | Sucrose | [36] | |
GH13_18 | Retaining | BAA14344.1 | Sucrose phosphorylase (LmSPase) | Leuconostoc mesenteroides ATCC 12291 | α-Glc1P | d-fructose | Sucrose | [37] | |
GH13_18 | Retaining | ABS59292.1 | Sucrose phosphorylase (742sp) | Leuconostoc mesenteroides B-742 | α-Glc1P | d-fructose | Sucrose | [38] | |
GH13_18 | Retaining | 2207198A | Sucrose phosphorylase | Leuconostoc mesenteroides NO. 165 | α-Glc1P | d-fructose | Sucrose | [39] | |
GH13_18 | Retaining | AAX33736.1 | Sucrose phosphorylase (LmSP1) | Leuconostoc mesenteroides NRRL B-1149 | α-Glc1P | d-fructose | Sucrose | [40] | |
GH13_18 | Retaining | AGK37834.1 | Sucrose phosphorylase (ScrP) | Limosilactobacillus reuteri LTH5448 | α-Glc1P | d-fructose | Sucrose | [41] | |
GH13_18 | Retaining | ADP98617.1 | Glucosylglycerol phosphorylase (HP15_2853) | Marinobacter adhaerens HP15 | α-Glc1P | d-glycerol | Glucosyl-glycerol: (α-d-glucopyranosyl-(1→2)-glycerol) | [42] | |
GH13_18 | Retaining | ADH62582.1 | Glucosylglycerate phosphorylase (MSGGaP;Mesil_0665) | Meiothermus silvanus DSM 9946 | α-Glc1P | d-glycerate | Glucosyl-glycerate: (α-d-glucopyranosyl-(1→2)-glycerate) | [28] | |
GH13_18 | Retaining | AAD40317.1 | Sucrose phosphorylase | Pelomonas saccharophila IAM 14368 | α-Glc1P | d-fructose | Sucrose | [43] | |
GH13_18 | Retaining | CCA61958.1 | Sucrose 6(F)-phosphate phosphorylase (RUGNEv3_61221;SucP) | Ruminococcus gnavus E1 | α-Glc1P | d-fructose-6-P | Sucrose-6-phosphate | [44] | |
GH13_18 | Retaining | AEJ61152.1 | Glucosylglycerate phosphorylase (Spith_0877) | Spirochaeta thermophila DSM 6578 | α-Glc1P | d-glycerate | Glucosyl-glycerate | [28] | |
GH13_18 | Retaining | CAA30846.1 | Sucrose phosphorylase (GftA;SmSP) | Streptococcus mutans INGBRITT/GS5 | α-Glc1P | d-fructose | Sucrose | [45] | |
GH13_18 | Retaining | AAN58596.1 | Sucrose phosphorylase (GtfA;SMU.881) | Streptococcus mutans UA159 | α-Glc1P | d-fructose | Sucrose | [46] | |
GH13_18 | Retaining | CAA80424.1* | Sucrose phosphorylase | Agrobacterium vitis | α-Glc1P | d-fructose | Sucrose | [47] | |
GH13_18 | Retaining | ADL69407.1 | Sucrose 6(F)-phosphate phosphorylase (SPP;TtSPP;Tthe_1921) | Thermoanaerobacterium thermosaccharolyticum DSM 571 | 6S9V | α-Glc1P | d-fructose-6-P | Sucrose-6-phosphate | [48] |
GH13_18 | Retaining | ACJ83248.1 | Sucrose phosphorylase (Unspase) | Uncultured bacterium | α-Glc1P | d-fructose | Sucrose | [49] | |
GH13_18 | Retaining | BAN03569.1 | Sucrose 6(F)-phosphate phosphorylase (YM304_32550) | Ilumatobacter coccineus YM16-304 | 6S9U | α-Glc1P | d-fructose-6-P | Sucrose-6-phosphate | [50] |
GH65 | Inverting | AAV43670.1 | Maltose phosphorylase (MalP;LBA1870) | Lactobacillus acidophilus NCFM | β-Glc1P | d-glucose | Maltose: (α-d-glucosyl-(1→4)-d-glucose) | [51] | |
GH65 | Inverting | ADH99560.1 | Maltose phosphorylase (Bsel_2056) | Bacillus selenitireducens MLS10 | β-Glc1P | d-glucose | Maltose | [52] | |
GH65 | Inverting | BAC54904.1 | Maltose phosphorylase (MPase) | Bacillus sp. RK-1 | β-Glc1P | d-glucose | Maltose | [53] | |
GH65 | Inverting | BAD97810.1 | Maltose phosphorylase (MapA) | Paenibacillus sp. SH-55 | β-Glc1P | d-glucose | Maltose | [27] | |
GH65 | Inverting | CAA11905.1 | Maltose phosphorylase | Fructilactobacillus sanfranciscensis DSM 20451(T) | β-Glc1P | d-glucose | Maltose | [54] | |
GH65 | Inverting | AAO80764.1 | Maltose phosphorylase (MalP;EF0957 | Enterococcus faecalis V583 | β-Glc1P | d-glucose | Maltose | [55] | |
GH65 | Inverting | Q7SIE1 | Maltose phosphorylase | Levilactobacillus brevis ATCC 8287 | 1H54 | β-Glc1P | d-glucose | Maltose | [56] |
GH65 | Inverting | BAQ19546.1 | Maltose phosphorylase (MalE) | Bacillus sp. AHU2001 | β-Glc1P | d-glucose | Maltose | [57] | |
GH65 | Inverting | BAB97299.1 | Trehalose phosphorylase (TreP) | Thermoanaerobacter brockii ATCC 35047 | Preliminary data PMID: 20383018 | β-Glc1P | d-glucose | Trehalose: (α-d-glucosyl-(1→1)-d-glucose) | [58] |
GH65 | Inverting | BAC20640.1 | Trehalose phosphorylase (TPase) | Geobacillus stearothermophilus SK-1 | β-Glc1P | d-glucose | Trehalose | [59] | |
GH65 | Inverting | KKC30106.1 | Trehalose phosphorylase (TP) | Caldanaerobacter subterraneus subsp. Pacificus DSM 12653 | β-Glc1P | d-glucose | Trehalose | [60] | |
GH65 | Inverting | ADG89586.1 | Trehalose phosphorylase (TbGP; Tbis_2887) | Thermobispora bispora DSM 43833 | β-Glc1P | d-glucose | Trehalose | [61] | |
GH65 | Inverting | AAK04526.1 | Trehalose-6-phosphate phosphorylase (TrePP;YeeA;L39593; LL0428) | Lactococcus lactis subsp. lactis Il1403 | β-Glc1P | d-glucose-6-phosphate | Trehalose-6-phosphate: (α-d-glucosyl-(1→1)-d-glucopyranoside-6-phosphate) | [62] | |
GH65 | Inverting | APF18594.1 | Trehalose-6-phosphate phosphorylase (CaGP;Cabys_1845) | Caldithrix abyssi DSM 13497 LF13 | β-Glc1P | d-glucose-6-phosphate | Trehalose-6-phosphate | [61] | |
GH65 | Inverting | AAE30762.1 | Kojibiose phosphorylase (KojP;KPase) | Thermoanaerobacter brockii ATCC 35047 | β-Glc1P | d-glucose | Kojibiose: (α-d-glucosyl-(1→2)-d-glucose) | [58] | |
GH65 | Inverting | AAC74398.1 | Kojibiose phosphorylase (YcjT) | Escherichia coli str. K-12 substr. MG1655 | β-Glc1P | d-glucose | Kojibiose | [63] | |
GH65 | Inverting | ABP66077.1 | Kojibiose phosphorylase (CsKP;Csac_0439) | Caldicellulosiruptor saccharolyticus DSM 8903 | 3WIQ, 3WIR | β-Glc1P | d-glucose | Kojibiose | [64] |
GH65 | Inverting | ACL68803.1 | Kojibiose phosphorylase (HoGP; Hore_00420) | Halothermothrix orenii H 168 | β-Glc1P | d-glucose | Kojibiose | [61] | |
GH65 | Inverting | ABX42243.1 | Nigerose phosphorylase (Cphy_1874) | Lachnoclostridium phytofermentans ISDg | β-Glc1P | d-glucose | Nigerose: (α-d-glucosyl-(1→3)-d-glucose) | [65] | |
GH65 | Inverting | ABX43667.1 | Nigerose phosphorylase (Cphy_3313) | Lachnoclostridium phytofermentans ISDg | β-Glc1P | d-glucose | Nigerose | [66] | |
GH65 | Inverting | ADQ05832.1 | 1,3-α-oligoglucan phosphorylase (ChGP;Calhy_0070) | Caldicellulosiruptor hydrothermalis 108 | β-Glc1P | Maltose Kojibiose Nigerose | α-1,3-oligoglucan | [61] | |
GH65 | Inverting | ADC90669.1 | Trisaccharide α-glucan phosphorylase (MiGP;HMPREF0868_0806) | Mageeibacillus indolicus UPII9-5 | β-Glc1P | Isomaltose Isomaltulose Maltose Kojibiose Nigerose | α-1,3-oligoglucan | [61] | |
GH65 | Inverting | ABX43668.1 | α-1,3-oligoglucan phosphorylase (Cphy_3314) | Lachnoclostridium phytofermentans ISDg | β-Glc1P | d-glucose | α-1,3-oligoglucan | [66] | |
GH65 | Inverting | ABX41399.1 | 3-O-α-glucopyranosyl-L-rhamnose phosphorylase (Cphy_1019) | Lachnoclostridium phytofermentans ISDg | β-Glc1P | l-rhamnose | α-d-glucopyranosyl-(1,3)-l-rhamnose | [25] | |
GH65 | Inverting | ADI00307.1 | α-1,2-glucosylglycerol phosphorylase (Bsel_2816) | Bacillus selenitireducens MLS10 | 4KTP, 4KTR | β-Glc1P | d-glycerol | (α-d-glucosyl-(1→2)-glycerol) | [67] |
GH94 | Inverting | AAB95491.2 | Cellobiose phosphorylase (CbpA) | Thermotoga neapolitana | α-Glc1P | d-glucose | Cellobiose: (β-d-glucopyranosyl-(1,4)-d-glucopyranose) | [68] | |
GH94 | Inverting | AAC45510.1 | Cellobiose phosphorylase (CepA) | Thermoclostridium stercorarium NCIB 11754 | α-Glc1P | d-glucose | Cellobiose | [69] | |
GH94 | Inverting | AAD36910.1 | Cellobiose phosphorylase (CepA;TM1848;Tmari_1863 | Thermotoga maritima MSB8 | α-Glc1P | d-glucose | Cellobiose | [70] | |
GH94 | Inverting | AAL67138.1 | Cellobiose phosphorylase (Cbp) | Acetivibrio thermocellus YM4 | 3QDE | α-Glc1P | d-glucose | Cellobiose | [71] |
GH94 | Inverting | AAQ20920.1 | Cellobiose phosphorylase (CbP) | Cellulomonas uda DSM 20108 | 3RRS, 3RSY, 3S4A, 3S4B, 3S4C, 3S4D | α-Glc1P | d-glucose | Cellobiose | [72] |
GH94 | Inverting | ABD80580.1 | Cellobiose phosphorylase 94A (Cbp;SdCBP;Sde1318, Cep94A) | Saccharophagus degradans 2-40 | α-Glc1P | d-glucose | Cellobiose | [73] | |
GH94 | Inverting | ABN51514.1 | Cellobiose phosphorylase (Cbp;CtCBP;Cthe_0275) | Acetivibrio thermocellus ATCC 27405 | α-Glc1P | d-glucose | Cellobiose | [74] | |
GH94 | Inverting | ACL76454.1 | Cellobiose phosphorylase (CbpA;Ccel_2109) | Ruminiclostridium cellulolyticum H10 | α-Glc1P | d-glucose | Cellobiose | [75] | |
GH94 | Inverting | ADU20744.1 | Cellobiose phosphorylase (CBP;RaCBP;Rumal_0187) | Ruminococcus albus 7 (DSM 20455) | α-Glc1P | d-glucose | Cellobiose | [24] | |
GH94 | Inverting | BAA25846.1 | Cellobiose-phosphorylase (Cbp) | Acetivibrio thermocellus YM4 | α-Glc1P | d-glucose | Cellobiose | [76] | |
GH94 | Inverting | BAA28631.1 | Cellobiose phosphorylase (Cbp;CgCBP) | Cellulomonas gilvus ATCC13127 | 2CQS, 2CQT, 3ACS, 3ACT, 3AFJ, 3QFY, 3QFZ, 3QG0 | α-Glc1P | d-glucose | Cellobiose | [77] |
GH94 | Inverting | CAB16926.1* | Cellobiose phosphorylase (CepA) | Thermotoga neapolitana Z2706-MC24 | α-Glc1P | d-glucose | Cellobiose | [78] | |
GH94 | Inverting | AAC45511.1 | Cellodextrin phosphorylase (CepB; CsCdP) | Thermoclostridium stercorarium DSM8532 | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [69] | |
GH94 | Inverting | ACL76454.1 | Cellobiose phosphorylase (CbpA;Ccel_2109) | Ruminiclostridium cellulolyticum H10 | α-Glc1P | d-glucose | Cellobiose | [29] | |
GH94 | Inverting | QCO92836.1 | Cellobiose phosphorylase (GH94_G) | Uncultured bacterium | α-Glc1P | d-glucose | Cellobiose | [79] | |
GH94 | Inverting | QCO92799.1 | Cellobiose phosphorylase (GH94_E) | Uncultured bacterium | α-Glc1P | d-glucose | Cellobiose | [79] | |
GH94 | Inverting | ADU22883.1 | Cellodextrin phosphorylase (CDP;RaCDP;Rumal_2403) | Ruminococcus albus 7 (DSM 20455) | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [80] | |
GH94 | Inverting | ACD71661.1 | Cyclic β-1,2-glucan synthetase (Cgs) | Brucella abortus S19 | α-Glc1P | [(1→2)-β-d-glucosyl]n | [(1→2)-β-d-glucosyl]n+1 | [81] | |
GH94 | Inverting | ACL75793.1 | Cellodextrin phosphorylase (CdpA; Ccel_1439) | Ruminiclostridium cellulolyticum H10 | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [29] | |
GH94 | Inverting | ACL77700.1 | Cellodextrin phosphorylase (CdpC; Ccel_3412) | Ruminiclostridium cellulolyticum H10 | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [29] | |
GH94 | Inverting | ACL76688.1 | Cellodextrin phosphorylase (CdpB; Ccel_2354) | Ruminiclostridium cellulolyticum H10 | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [29] | |
GH94 | Inverting | QCO92991.1 | Cellodextrin phosphorylase (GH94_A) | Uncultured bacterium | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [29] | |
GH94 | Inverting | QCO92946.1 | Cellodextrin phosphorylase (GH94_D) | Uncultured bacterium | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [29] | |
GH94 | Inverting | BAJ10826.1 | Laminaribiose phosphorylase (LbpA) | Paenibacillus sp. YM1 | 6GGY, 6GH2, 6GH3 | α-Glc1P | d-glucose | Laminaribiose: (β-d-glucopyranosyl-(1,3)-d-glucopyranose) | [82,83] |
GH94 | Inverting | AAG23740.1 | Diacetylchitobiose phosphorylase (ChbP) | Vibrio furnissii | α-GlcNAc-1P | N-acetyl-d-glucosamine | N,N’-diacetylchitobiose: (N-acetyl-d-glucosaminyl-(1,4)-N-acetyl-d-glucosamine) | [84] | |
GH94 | Inverting | BAC87867.1 | Chitobiose phosphorylase (ChbP;VpChBP) | Vibrio proteolyticus | 1V7V, 1V7W, 1V7X | α-GlcNAc-1P | N-acetyl-d-glucosamine | N,N’-diacetylchitobiose | [85] |
GH94 | Inverting | AFH48717.1 | Chitobiose phosphorylase (IaGP;IALB_1006) | Ignavibacterium album JCM 16511 | α-GlcNAc-1P | N-acetyl-d-glucosamine | N,N’-diacetylchitobiose | [86] | |
GH94 | Inverting | CAC97070.1 | β-1,2-oligoglucan phosphorylase (LiSOGP;Lin1839) | Listeria innocua Clip11262 | α-Glc1P | [(1→2)-β-d-glucosyl]n | [(1→2)-β-d-glucosyl]n+1 | [87] | |
GH94 | Inverting | ABX41081.1 | β-1,2-oligoglucan phosphorylase (LpSOGP;Cphy_0694) | Lachnoclostridium phytofermentans ISDg | 5H3Z, 5H40, 5H41, 5H42 | α-Glc1P | [(1→2)-β-d-glucosyl]n | [(1→2)-β-d-glucosyl]n+1 | [88] |
GH94 | Inverting | QCO92990.1 | Laminaribiose phosphorylase (GH94_B) | Uncultured bacterium | α-Glc1P | d-glucose | Laminaribiose | [79] | |
GH94 | Inverting | QCO92945.1 | Laminaribiose phosphorylase (GH94_C) | Uncultured bacterium | α-Glc1P | d-glucose | Laminaribiose | [79] | |
GH94 | Inverting | BAB71818.1 | Cellodextrin phosphorylase (Cdp-ym4) | Acetivibrio thermocellus YM4 | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [71] | |
GH94 | Inverting | ABN54185.1 | Cellodextrin-phosphorylase (Cdp;CtCDP;Cthe_2989) | Acetivibrio thermocellus ATCC 27405 | 5NZ7, 5NZ8 | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [89] |
GH94 | Inverting | ADZ85667.1* | Cellodextrin phosphorylase (Cdp;ClCDP;Clole_3989) | Clostridium lentocellum | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [73] | |
GH94 | Inverting | AAM43298.1 | Cellobionic acid phosphorylase (CelAP;NdvB;XCC4077) | Xanthomonas campestris pv. campestris str. ATCC 33913 | α-Glc1P | d-gluconate | β-d-glucopyranosyl-(1,4)-d-gluconate | [90] | |
GH94 | Inverting | ABD80168.1 | Cellobionic acid phosphorylase 94B (Cep94B;CBAP; SdCBAP;Sde_0906) | Saccharophagus degradans 2-40 | 4ZLE, 4ZLF, 4ZLG, 4ZLI | α-Glc1P | d-gluconate | β-d-glucopyranosyl-(1,4)-d-gluconate | [91] |
GH94 | Inverting | EAA28929.1 | Cellobionic acid phosphorylase (CelAP;NdvB; NCU09425) | Neurospora crassa OR74A | α-Glc1P | d-gluconate | β-d-glucopyranosyl-(1,4)-d-gluconate | [90] | |
GH94 | Inverting | AAC45511.1 | Cellodextrin phosphorylase (CepB;CsCdP) | Thermoclostridium stercorarium DSM8532 | α-Glc1P | [(1→4)-β-d-glucosyl]n | [(1→4)-β-d-glucosyl]n+1 | [69] | |
GH94 | Inverting | AHC20114.1 | Glucosylgalactose Phosphorylase (GGalP) | Paenibacillus polymyxa CR1 | α-Glc1P | d-galactose | β-d-glucopyranosyl-(1,4)-d-galactose | [86] | |
GH94 | Inverting | ABX81345.1 | Laminaribiose phosphorylase (ACL_0729;ACL0729) | Acholeplasma laidlawii PG-8A | α-Glc1P | d-glucose | Laminaribiose | [92] | |
GH112 | Inverting | ACB74662.1 | D-galactosyl-β-1,4-L-rhamnose phosphorylase (GalRhaP;Oter_1377) | Opitutus terrae PB90-1 | α-Gal1P | l-rhamnose | (β-d-galactosyl-(1,4)-l-rhamnose) | [93] | |
GH112 | Inverting | ABX42289.1 | D-galactosyl-β-1,4-L-rhamnose phosphorylase (Cphy_1920) | Lachnoclostridium phytofermentans ISDg | α-Gal1P | l-rhamnose | (β-d-galactosyl-(1,4)-l-rhamnose) | [94] | |
GH112 | Inverting | AAO07997.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase (GalGlyNAcP;VV2_1091) | Vibrio vulnificus CMCP6 | α-Gal1P | N-acetyl-d-glucosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) | [95] | |
GH112 | Inverting | ABX40964.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase (Cphy_0577) | Lachnoclostridium phytofermentans ISDg | α-Gal1P | N-acetyl-d-glucosamine N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [94] | |
GH112 | Inverting | ABX43387.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase (Cphy_3030) | Lachnoclostridium phytofermentans ISDg | α-Gal1P | N-acetyl-d-glucosamine N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [94] | |
GH112 | Inverting | AEN95946.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase (RhGLnbp112;RHOM_04120) | Roseburia hominis A2-183 | α-Gal1P | N-acetyl-d-glucosamine N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [96] | |
GH112 | Inverting | EEG94248.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase (RiGLnbp112; ROSEINA2194_01886; GnpA) | Roseburia inulinivorans DSM 16841 | α-Gal1P | N-acetyl-d-glucosamine N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [96] | |
GH112 | Inverting | BAD80751.1 | Galacto-N-biose/lacto-N-biose phosphorylase (LnpA1;LnbP;GLNBP; BLLJ_1623) | Bifidobacterium longum subsp. longum JCM 1217 | 2ZUS, 2ZUT, 2ZUU, 2ZUV, 2ZUW, 3WFZ | α-Gal1P | N-acetyl-d-glucosamine N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [97] |
GH112 | Inverting | BAD80752.1 | Lacto-N-biose phosphorylase (LnpA1;LnbP) | Bifidobacterium bifidum JCM 1254 | α-Gal1P | N-acetyl-d-glucosamine N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [98] | |
GH112 | Inverting | ACV29689.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase/galacto-N-biose/lacto-N-biose I phosphorylase (GLNBP;Apre_1669) | Anaerococcus prevotii DSM 20548 | α-Gal1P | N-acetyl-d-glucosamine N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-glucosamine) (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [26] | |
GH112 | Inverting | ZP_05748149.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase/galacto-N-biose phosphorylase (GNBP;HMPREF0357_1319) | Erysipelothrix rhusiopathiae ATCC 19414 | α-Gal1P | N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [26] | |
GH112 | Inverting | ACZ00636.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase/galacto-N-biose phosphorylase (GNBP;Smon_0146) | Streptobacillus moniliformis DSM 12112 | α-Gal1P | N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [26] | |
GH112 | Inverting | ABG83511.1 | Galacto-N-biose phosphorylase (CPF_0553) | Clostridium perfringens ATCC 13124 | α-Gal1P | N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [95] | |
GH112 | Inverting | BAH10636.1 | β-1,3-galactosyl-N-acetylhexosamine phosphorylase (GnpA) | Cutibacterium acnes JCM 6425 | α-Gal1P | N-acetyl-d-galactosamine | (β-d-galactosyl-(1,3)-N-acetyl-d-galactosamine) | [99] | |
GH130 | Inverting | CAC96089.1 | β-1,2-mannobiose phosphorylase (Lin0857) | Listeria innocua Clip11262 | 5B0P, 5B0Q, 5B0R, 5B0S | α-Man1P | d-mannose | β-1,2-mannobiose | [100] |
GH130 | Inverting | ABY93074.1 | β-1,2-mannobiose phosphorylase (Teth514_1789) | Thermoanaerobacter sp. X514 | 7FIP, 7FIQ, 7FIR, 7FIS | α-Man1P | d-mannose | β-1,2-mannobiose | [101] |
GH130 | Inverting | ABY93073.1 | β-1,2-oligomannan phosphorylase (Teth514_1788) | Thermoanaerobacter sp. X514 | α-Man1P | (β-1,2-d-mannose)n | (β-1,2-d-mannose)n+1 | [101] | |
GH130 | Inverting | CAZ94304.1 | β-1,3-mannooligosaccharide phosphorylase (zobellia_231) | Zobellia galactanivorans DsijT | α-Man1P | (β-1,3-d-mannose)n | (β-1,3-d-mannose)n+1 | [102] | |
GH130 | Inverting | AAS19693.1 | β-1,4-mannosylglucose phosphorylase (UnkA, CvMGP) | Cellvibrio vulgaris NCIMB8633 | α-Man1P | d-glucose | β-mannopyranosyl-(1→4)-d-glucopyranose | [103] | |
GH130 | Inverting | ADU21379.1 | β-1,4-mannosylglucose phosphorylase (RaMP1; RaMGP; Rumal_0852) | Ruminococcus albus 7 (DSM 20455) | 5AY9, 5AYC | α-Man1P | d-glucose | β-mannopyranosyl-(1→4)-d-glucopyranose | [104] |
GH130 | Inverting | CAH06518.1 | β-1,4-mannosylglucose phosphorylase (MGP; BF0772) | Bacteroides fragilis NCTC 9343 | 3WAS, 3WAT, 3WAU, 4KMI | α-Man1P | d-glucose | β-mannopyranosyl-(1→4)-d-glucopyranose | [105] |
GH130 | Inverting | VCV21228.1 | β-1,4-mannosylglucose phosphorylase (RIL182_01099; ROSINTL182_07685) | Roseburia intestinalis L1-82 | α-Man1P | d-glucose | β-mannopyranosyl-(1→4)-d-glucopyranose | [106] | |
GH130 | Inverting | ACY49318.1 | β-1,4-mannosylglucose phosphorylase (MGP; RmMGP; Rmar_2440) | Rhodothermus marinus R-10T (ATCC43812) | α-Man1P | d-glucose | β-mannopyranosyl-(1→4)-d-glucopyranose | [107] | |
GH130 | Inverting | AAO76140.1 | β-1,4-mannosyl-N-acetyl-glucosamine phosphorylase (BT1033) | Bacteroides thetaiotaomicron VPI-5482 | α-Man1P | N-acetyl-d-glucosamine | β-mannopyranosyl-(1→4)-N-acetyl-d-glucosamine | [108] | |
GH130 | Inverting | ADD61463.1 | β-1,4-mannopyranosyl-[N-glycan] phosphorylase β-1,4-mannopyranosyl-chitobiose phosphorylase (Uhgb_MP) | Uncultured bacterium | 4UDG, 4UDI, 4UDJ, 4UDK | α-Man1P | β-N-acetyl-d-glucosaminyl-(1,4)-N-acetyl-d-glucosamine | β-1,4-mannopyranosyl-chitobiose (β-mannopyranosyl-(1→4)-N-acetyl-β-d-glucosaminyl-(1→4)-N-acetyl-d-glucosamine) | [109] |
GH130 | Inverting | ADU20661.1 | β-1,4-mannooligosaccharide phosphorylase (MOP; RaMP2; Rumal_0099) | Ruminococcus albus 7 (DSM 20455) | 5AYD, 5AYE | α-Man1P | (β-1,4-d-mannose)n | (β-1,4-d-mannose)n+1 | [104] |
GH130 | Inverting | VCV21229.1 | β-1,4-mannooligosaccharide phosphorylase (RIL182_01100; ROSINTL182_05474) | Roseburia intestinalis L1-82 | α-Man1P | (β-1,4-d-mannose)n | (β-1,4-d-mannose)n+1 | [106] | |
GH130 | Inverting | AAD36300.1 | β-1,4-mannooligosaccharide phosphorylase (TM1225) | Thermotoga maritima MSB8 | 1VKD | α-Man1P | (β-1,4-d-mannose)n | (β-1,4-d-mannose)n+1 | [110] |
GH130 | Inverting | WP_026485574.1 | β-1,4-mannooligosaccharide phosphorylase (CalpoDRAFT_0075) | Caldanaerobius polysaccharolyticus ATCC BAA-17 | α-Man1P | (β-1,4-d-mannose)n | (β-1,4-d-mannose)n+1 | [111] | |
GH130 | Inverting | WP_026486530.1 | β-1,4-mannooligosaccharide phosphorylase (CalpoDRAFT_1209) | Caldanaerobius polysaccharolyticus ATCC BAA-17 | α-Man1P | (β-1,4-d-mannose)n | (β-1,4-d-mannose)n+1 | [111] | |
GH130 | Inverting | CAH1385115.1 | β-1,4-mannosyl-glucuronic acid phosphorylase | Uncultured bacterium | α-Man1P | d-glucuronic acid | β-mannopyranosyl-(1→4)-d-glucuronic acid | [112] | |
GH130 | Inverting | CAH1385116.1 | β-1,4-mannooligosaccharide phosphorylase | Uncultured bacterium | α-Man1P | d-mannose β-1,4-mannobiose | β-1,4-mannobiose β-1,4-mannotriose | [112] | |
GH130 | Inverting | CAH1385117.1 | β-1,3-mannosyl-glucose phosphorylase β-1,3-mannooligosaccharide phosphorylase | Uncultured bacterium | α-Man1P | d-glucose d-mannose | β-mannopyranosyl-(1→3)-d-glucopyranose β-1,3-mannobiose | [112] | |
GH130 | Inverting | CAH1385118.1 | Mixed-linkage mannoside synthase Uhgb_MS | Uncultured bacterium | α-Man1P | d-mannose α-1,2-mannobiose | β-1,2-mannobiose α-1,2-mannotriose β-d-mannopyranosyl-(1→2)-α-1,2-mannotriose | [113] | |
GH149 | Inverting | β-1,3-oligoglucan phosphorylase (Pro_7066) | Uncultured bacterium | 6HQ6, 6HQ8, 6HQ6 | α-Glc1P | [(1→3)-β-d-glucosyl]n | [(1→3)-β-d-glucosyl]n+1 | [114] | |
GH149 | Inverting | AUO30192.1 | β-1,3-glucan phosphorylase (EgP1) | Euglena gracilis | α-Glc1P | [(1→3)-β-d-glucosyl]n | [(1→3)-β-d-glucosyl]n+1 | [115] | |
GH149 | Inverting | QCO92814.1 | β-1,3-glucan phosphorylase (GH149_H) | Uncultured bacterium | α-Glc1P | [(1→3)-β-d-glucosyl]n | [(1→3)-β-d-glucosyl]n+1 | [79] | |
GH161 | Inverting | WP_019688419.1 | β-1,3-glucan phosphorylase (PPT_RS0121460; PapP) | Paenibacillus polymyxa ATCC 842 | α-Glc1P | [(1→3)-β-d-glucosyl]n | [(1→3)-β-d-glucosyl]n+1 | [116] | |
GH161 | Inverting | ACJ76363.1 | β-1,3-glucan phosphorylase (THA_1941; TaCDP) | Thermosipho africanus TCF52B | α-Glc1P | [(1→3)-β-d-glucosyl]n | [(1→3)-β-d-glucosyl]n+1 | [116] | |
GH161 | Inverting | BAU78234.1 | β-1,3-glucan phosphorylase (OdBGP) | Ochromonas danica NIES-2142 | α-Glc1P | [(1→3)-β-d-glucosyl]n | [(1→3)-β-d-glucosyl]n+1 | [117] | |
GT4 | Retaining | BAA31350.1 | Trehalose synthase (Tsase) | Grifola frondosa | α-Glc1P | d-glucose | Trehalose: (α-d-glucosyl-(1,1)-d-glucose) | [118] | |
GT4 | Retaining | AAF22230.1 | Threalose phosphorylase (PsTP) | Lentinus sajor-caju ASI2070 (Pleurotus sajor-caju) | α-Glc1P | d-glucose | trehalose | [119] | |
GT4 | Retaining | ABC84380.1 | Threalose phosphorylase | Schizophyllum commune BT2115 | α-Glc1P | d-glucose | trehalose | [120,121] | |
GT35 | Retaining | ABP51432.1 | Glucan/maltodextrin phosphorylase (GlgP; PyglgP; Pars_1881) | Pyrobaculum arsenaticum DSM 13514 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [122] | |
GT35 | Retaining | AAL81659.1 | α-glucan/maltodextrin phosphorylase (PF1535) | Pyrococcus furiosus DSM 3638 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [123,124] | |
GT35 | Retaining | AAD28735.1 | Maltodextrin phosphorylase (MalP) | Thermococcus litoralis | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [125] | |
GT35 | Retaining | ABN51595.1 | α-glucan phosphorylase (α-GP; Cthe_0357) | Acetivibrio thermocellus ATCC 27405 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [126] | |
GT35 | Retaining | CAB61943.1 | α-glucan phosphorylase (PHS2; AtPHS2; At3g46970) | Arbidopsis thaliana | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [127] | |
GT35 | Retaining | AAD03471.1 | Glycogen phosphorylase (GlgP) | Agrobacterium tumefaciens A348 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [128] | |
GT35 | Retaining | AAC06896.1 | Glycogen phosphorylase (GlgP; Aq_717) | Aquifex aeolicus VF5 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [129] | |
GT35 | Retaining | AAC00218.1 | Glycogen phosphorylase (GlgP; BSU30940) | Bacillus subtilis subsp. subtilis str. 168 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [130] | |
GT35 | Retaining | AAM24997.1 | α-glucan phosphorylase (GlgP; TTE1805) | Caldanaerobacter subterraneus subsp. tengcongensis MB4 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [131] | |
GT35 | Retaining | AAM52219.1 | Glycogen phosphorylase | Corynebacterium callunae | 2C4M | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [132] |
GT35 | Retaining | BAB98701.1 | Maltodextrin/glycogen phosphorylase (MalP; GlgP1; cg1479) | Corynebacterium glutamicum ATCC 13032 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [133] | |
GT35 | Retaining | BAB99480.1 | Glycogen phosphorylase (GlgP; GlgP2; cg2289) | Corynebacterium glutamicum ATCC 13032 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [133] | |
GT35 | Retaining | AAC76453.1 | Glycogen phosphorylase (GlgP; b3428) | Escherichia coli str. K-12 substr. MG1655 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [134] | |
GT35 | Retaining | AAC76442.1 | Maltodextrin phosphorylase (MalP; b3417) | Escherichia coli str. K-12 substr. MG1655 | 1AHP, 1E4O, 1L5V, 1L5W, 1L6I, 1QM5, 2ASV, 2AV6, 2AW3, 2AZD, 2ECP | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [135] [136] |
GT35 | Retaining | BAA19592.1 | Glycogen phosphorylase (GlgP) | Geobacillus stearothermophilus TRBE14 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [137] | |
GT35 | Retaining | AAN59210.1 | Maltodextrin phosphorylase (GlgP; SMU.1564) | Streptococcus mutans UA159 | 4L22 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [138] |
GT35 | Retaining | AAL26558.1 | Glycogen phosphorylase (Glg) | Synechococcus elongatus PCC 7942 = FACHB-805 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [139] | |
GT35 | Retaining | AGL50099.1 | α-glucan phosphorylase (AgpA; Tmari_1175) | Thermotoga maritima MSB8 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [140] | |
GT35 | Retaining | BAB11741.1 | α-glucan phosphorylase (GlgP) | Thermus aquaticus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [141] | |
GT35 | Retaining | CAC93400.1 | Glycogen phosphorylase (glgP, YPO3938) | Yersinia pestis CO92 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [142] | |
GT35 | Retaining | AAB46846.1 | Glycogen phosphorylase (myophosphorylase) | Bos taurus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [143] | |
GT35 | Retaining | ABB88567.1 | Plastidial starch phosphorylase (PhoB; Sta4) | Chlamydomonas reinhardtii 137C | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [144] | |
GT35 | Retaining | CAA44069.1 | Glycogen phosphorylase 1 (GlpV; GP1) | Dictyostelium discoideum | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [145] | |
GT35 | Retaining | AAA33211.1 | Glycogen phosphorylase 2 (GlpD; GP2) | Dictyostelium discoideum | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [146] | |
GT35 | Retaining | AAD46887.1 | glycogen phosphorylase (GlyP; GLYP; CG7254; Dmel_CG7254) | Drosophila melanogaster | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [147] | |
GT35 | Retaining | AAN17338.1 | Glycogen phosphorylase-2 | Entamoeba histolytica | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [148] | |
GT35 | Retaining | AAL23578.1 | Glycogen phosphorylase | Entamoeba histolytica | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [148] | |
GT35 | Retaining | AAP33020.1 | Glycogen phosphorylase | Gallus gallus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [149] | |
GT35 | Retaining | AAK69600.1 | Glycogen phosphorylase | Giardia intestinalis ATCC30957 | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [148] | |
GT35 | Retaining | AAB60395.1 | Glycogen phosphorylase (brain) (bGP) | Homo sapiens | 5IKO, 5IKP | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [150] |
GT35 | Retaining | CAA75517.1 | Glycogen phosphorylase (liver) | Homo sapiens | 1EM6, 1EXV, 1FA9, 1FC0, 1L5Q, 1L5R, 1L5S, 1L7X, 1XOI, 2ATI, 2QLL, 2ZB2, 3CEH, 3CEJ, 3CEM, 3DD1, 3DDS, 3DDW | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [151] |
GT35 | Retaining | AAC17451.1 | Glycogen phosphorylase (muscle) (PigM) | Homo sapiens | 1Z8D | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [152] |
GT35 | Retaining | BAK00834.1 | Plastidial α-1,4-glucan phosphorylase (Pho1; HvPho1) | Hordeum vulgare subsp. Vulgare | 5LR8, 5LRA, 5LRB | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [153] |
GT35 | Retaining | AAA63271.1 | α-glucan phosphorylase L | Ipomoea batatas | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [154] | |
GT35 | Retaining | AAK01137.1 | Starch phosphorylase (fragment) | Ipomoea batatas | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [155] | |
GT35 | Retaining | AAL23577.1 | Glycogen phosphorylase | Mastigamoeba balamuthi | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [148] | |
GT35 | Retaining | AAD30476.1 | Glycogen phosphorylase (muscle) (PygM) | Mus musculus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [156] | |
GT35 | Retaining | AAG00588.1 | Glycogen phosphorylase | Mus musculus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [157] | |
GT35 | Retaining | ACJ76617.1 | Glycogen phosphorylase (muscle) (PygM) | Oryctolagus cuniculus | Dozens available—2GJ4[A] best solution | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [158,159] |
GT35 | Retaining | AAK15695.1 | α-1,4-glucan phosphorylase L | Oryza sativa | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [160] | |
GT35 | Retaining | BAB92854.1 | α-1,4-glucan phosphorylase (Os01g0851700) | Oryza sativa Japonica Group | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [161] | |
GT35 | Retaining | AAV87308.1 | brain glycogen phosphorylase (PYGB) | Ovis aries | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [162] | |
GT35 | Retaining | AAB68800.1 | glycogen phosphorylase (muscle) | Ovis aries | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [163] | |
GT35 | Retaining | AAA41252.1 | glycogen phosphorylase (Brain) | Rattus norvegicus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [164] | |
GT35 | Retaining | AAH70901.1 | glycogen phosphorylase (liver) | Rattus norvegicus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [165] | |
GT35 | Retaining | AAA41253.1 | glycogen phosphorylase (muscle) | Rattus norvegicus | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [166] | |
GT35 | Retaining | AAB68057.1 | Glycogen phosphorylase (Gph1; YPR160w) | Saccharomyces cerevisiae S288c | 1YGP | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [167,168] |
GT35 | Retaining | AAA33809.1 | α-glucan phosphorylase H | Solanum tuberosum | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [169] | |
GT35 | Retaining | BAA00407.1 | α-glucan phosphorylase L1 | Solanum tuberosum | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [170] | |
GT35 | Retaining | CAA52036.1 | α-glucan phosphorylase L2 | Solanum tuberosum | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [171] | |
GT35 | Retaining | CAA59464.1 | α-glucan phosphorylase | Spinacia oleracea | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [159] | |
GT35 | Retaining | AAL23579.1 | glycogen phosphorylase | Trichomonas vaginalis | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [148] | |
GT35 | Retaining | AAF82787.1 | α-glucan phosphorylase | Triticum aestivum | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [172] | |
GT35 | Retaining | CAA84494.1 | α-glucan phosphorylase (Pho2;VfPho2) | Vicia faba var. minor | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [173] | |
GT35 | Retaining | CAA85354.1 | α-glucan phosphorylase L | Vicia faba var. minor | α-Glc1P | [(1→4)-α-d-glucosyl]n | [(1→4)-α-d-glucosyl]n+1 | [173] | |
GT108 | Inverting | CBZ24448.1 | MTP3 (LMXM_10_1250) | Leishmania mexicana MHOM/GT/2001/U1103 | α-Man1P | (β-1,2-d-mannose)n | (β-1,2-d-mannose)n+1 | [174] | |
GT108 | Inverting | CBZ24451.1 | MTP6 (LMXM_10_1280) | Leishmania mexicana MHOM/GT/2001/U1103 | α-Man1P | (β-1,2-d-mannose)n | (β-1,2-d-mannose)n+1 | [174] | |
GT108 | Inverting | CBZ24449.1 | MTP4 (LMXM_10_1260) | Leishmania mexicana MHOM/GT/2001/U1103 | 6Q50 | α-Man1P | (β-1,2-d-mannose)n | (β-1,2-d-mannose)n+1 | [174] |
GT108 | Inverting | CBZ24452.1 | MTP7 (LMXM_10_1290) | Leishmania mexicana MHOM/GT/2001/U1103 | α-Man1P | (β-1,2-d-mannose)n | (β-1,2-d-mannose)n+1 | [174] |
CAZy Family | GenBank/ UniProtKB Accession | Organism Name | PDB Accession Numbers | Protein Name | Fold | Quaternary Structure | Reference |
---|---|---|---|---|---|---|---|
GH3 | AUG44408.1 | Uncultured bacterium | 5VQD[A], 5VQE[A] | β-glucoside phosphorylase (BglP) | (β/α)8 | Monomer | [30] |
GH13_18 | AAO33821.1 | Bifidobacterium adolescentis DSM 20083 | 1R7A[A,B], 2GDU[A,B], 2GDV[A,B], 5C8B[B], 5M9X[B], 5MAN[B], 5MB2[B], 6FME[A,B] | Sucrose phosphorylase (SucP; SP; BaSP) | (β/α)8 | Dimer | [196] |
GH13_18 | BAN03569.1 | Ilumatobacter coccineus YM16-304 | 6S9U[A] | Sucrose 6(F)-phosphate phosphorylase (YM304_32550) | (β/α)8 | Monomer | [50] |
GH13_18 | ADL69407.1 | Thermoanaerobacterium thermosaccharolyticum DSM 571 | 6S9V[A,B] | Sucrose 6(F)-phosphate phosphorylase (SPP; TtSPP; Tthe_1921) | (β/α)8 | Monomer | [50] |
GH65 | Q7SIE1 | Levilactobacillus brevis ATCC 8287 | 1H54[A] | Maltose phosphorylase | (α/α)6 | Dimer | [197] |
GH65 | ADI00307.1 | Bacillus selenitireducens MLS10 | 4KTP[A,B], 4KTR[A,B,C,D,E,F,G,H] | 2-O-α-glucopyranosylglycerol: phosphate β-glucosyltransferase/ 2-O-α-glucosylglycerol phosphorylase (GGP; Bsel_2816) | (α/α)6 | Dimer | [198] |
GH65 | ABP66077.1 | Caldicellulosiruptor saccharolyticus DSM 8903 | 3WIQ[A], 3WIR[A,B,C,D] | Kojibiose phosphorylase (CsKP; Csac_0439 | (α/α)6 | Dimer | [199] |
GH65 | / | Uncultured bacterium | 6W0P[B,C,D], 6W0P[A] | Kojibiose phosphorylase | (α/α)6 | Dimer | Unpublished |
GH65 | BAB97299.1 | Thermoanaerobacter brockii ATCC 35047 | Trehalose phosphorylase (TreP) | (α/α)6 | Dimer | [200] | |
GH94 | ABN54185.1 | Acetivibrio thermocellus ATCC 27405 | 5NZ7[A,B], 5NZ8[A,B] | Cellodextrin-phosphorylase (Cdp; CtCDP; Cthe_2989) | (α/α)6 | Dimer | [201] |
GH94 | AAL67138.1 | Acetivibrio thermocellus YM4 | 3QDE[A,B] | Cellobiose phosphorylase (Cbp) | (α/α)6 | Dimer | [202] |
GH94 | BAA28631.1 | Cellulomonas gilvus ATCC13127 | 2CQS[A,B], 2CQT[A,B], 3ACS[A,B], 3ACT[A,B], 3AFJ[A,B], 3QFY[A,B], 3QFZ[A,B], 3QG0[A,B] | Cellobiose phosphorylase (Cbp; CgCBP) | (α/α)6 | Dimer | [203,204] |
GH94 | AAQ20920.1 | Cellulomonas uda DSM 20108 | 3RRS[A,B], 3RSY[A,B], 3S4A[A,B], 3S4B[A,B], 3S4C[A], 3S4D[A] | Cellobiose phosphorylase (CbP) | (α/α)6 | Dimer | Unpublished |
GH94 | ABX41081.1 | Lachnoclostridium phytofermentans ISDg | 5H3Z[A,B], 5H40[A,B], 5H41[A,B], 5H42[A,B] | β-1,2-oligoglucan phosphorylase (LpSOGP; Cphy_0694) | (α/α)6 | Monomer | [88] |
GH94 | BAJ10826.1 | Paenibacillus sp. YM1 | 6GGY[A,B], 6GH2[A,B], 6GH3[A,B] | Laminaribiose phosphorylase (LbpA) | (α/α)6 | Dimer | [116] |
GH94 | ABD80168.1 | Saccharophagus degradans 2-40 | 4ZLE[A], 4ZLF[A], 4ZLG[A], 4ZLI[A] | Cellobionic acid phosphorylase 94B (Cep94B; CBAP; SdCBAP; Sde_0906) | (α/α)6 | Dimer | [91] |
GH94 | BAC87867.1 | Vibrio proteolyticus | 1V7V[A], 1V7W[A], 1V7X[A] | Chitobiose phosphorylase (ChbP; VpChBP) | (α/α)6 | Dimer | [205] |
GH112 | BAD80751.1 | Bifidobacterium longum subsp. longum JCM 1217 | 2ZUS[A,B,C,D], 2ZUT[A,B,C,D], 2ZUU[A,B,C,D], 2ZUV[A,B], 2ZUW[A,B,C,D], 3WFZ[A,B,C,D] | Galacto-N-biose phosphorylase/Lacto-N-biose phosphorylase (LnpA1; LnbP; GLNBP; BLLJ_1623) | (β/α)8 | Dimer | [206,207] |
GH130 | CAH06518.1 | Bacteroides fragilis NCTC 9343 | 3WAS[A,B], 3WAT[A,B], 3WAU[A,B], 4KMI[A,B | β-1,4-mannosylglucose phosphorylase (MGP; BF0772) | 5-fold β-propeller | Hexamer | [208] |
GH130 | CAC96089.1 | Listeria innocua Clip11262 | 5B0P[A,B], 5B0Q[A,B], 5B0R[A,B], 5B0S[A,B] | β-1,2-mannobiose phosphorylase (Lin0857) | 5-fold β-propeller | Dimer | [100] |
GH130 | ADU21379.1 | Ruminococcus albus 7 (DSM 20455) | 5AY9[A], 5AYC[A] | β-1,4-mannosylglucose phosphorylase (RaMP1; RaMGP; Rumal_0852) | 5-fold β-propeller | Trimer | [209] |
GH130 | ADU20661.1 | Ruminococcus albus 7 (DSM 20455) | 5AYD[A,B,C,D,E,F], 5AYE[A,B,C,D,E,F] | β-1,4-mannooligosaccharide phosphorylase (MOP; RaMP2; Rumal_0099) | 5-fold β-propeller | Hexamer | [209] |
GH130 | ABY93074.1 | Thermoanaerobacter sp. X514 | 7FIP, 7FIQ, 7FIR, 7FIS | β-1,2-mannobiose phosphorylase (Teth514_1789) | 5-fold β-propeller | Monomer | [210] |
GH130 | AAD36300.1 | Thermotoga maritima MSB8 | 1VKD[A,B,C,D,E,F] | β-1,4-mannooligosaccharide phosphorylase (TM1225) | 5-fold β-propeller | Dimer | Unpublished |
GH130 | ADD61463.1 | Uncultured bacterium | 4UDG[A,B,C,D,E,F], 4UDI[A,B,C,D,E,F], 4UDJ[A,B,C,D,E,F], 4UDK[A,B,C,D,E,F] | β-1,4-mannopyranosyl-[N-glycan] phosphorylase/β-1,4-mannopyranosyl-chitobiose phosphorylase (UhgbMP; Uhgb_MP) | 5-fold β-propeller | Hexamer | [195] |
GH149 | / | Uncultured bacterium | 6HQ6[B], 6HQ8[A,B], 6HQ6[A] | β-1,3-oligoglucan phosphorylase (Pro_7066) | (α/α)6 | Dimer | [114] |
GT35 | AAM52219.1 | Corynebacterium callunae | 2C4M[A,B,C,D] | Glycogen phosphorylase | GT-B | Dimer | Unpublished |
GT35 | AAC76442.1 | Escherichia coli str. K-12 substr. MG1655 | 1AHP[A], 1E4O[A], 1L5V[A], 1L5W[A], 1L6I[A], 1QM5[A], 2ASV[A,B], 2AV6[A,B], 2AW3[A,B], 2AZD[A,B], 2ECP[A | Maltodextrin phosphorylase (MalP; b3417) | GT-B | Dimer | [136,211,212,213] |
GT35 | AAN59210.1 | Streptococcus mutans UA159 | 4L22[A] | Maltodextrin phosphorylase (GlgP; SMU.1564) | GT-B | Monomer | Unpublished |
GT35 | CAB61943.1 | Arabidopsis thaliana | 4BQE[A,B], 4BQF[A,B], 4BQI[A,B] | α-glucan phosphorylase (PHS2; AtPHS2; At3g46970) | GT-B | Dimer | [127] |
GT35 | AAB60395.1 | Homo sapiens | 5IKO[A], 5IKP[A] | Glycogen phosphorylase (brain) (bGP) | GT-B | Dimer | [214] |
GT35 | CAA75517.1 | Homo sapiens | 1EM6[A,B], 1EXV[A,B], 1FA9[A], 1FC0[A,B], 1L5Q[A,B], 1L5R[A,B], 1L5S[A,B], 1L7X[A,B], 1XOI[A,B], 2ATI[A,B], 2QLL[A], 2ZB2[A,B], 3CEH[A,B], 3CEJ[A,B], 3CEM[A,B], 3DD1[A,B], 3DDS[A,B], 3DDW[A,B] | Glycogen phosphorylase (liver) | GT-B | Dimer | [215,216,217,218,219,220,221,222,223] |
GT35 | AAC17451.1 | Homo sapiens | 1Z8D[A] | Glycogen phosphorylase (muscle) (PigM) | GT-B | Dimer | [224] |
GT35 | BAK00834.1 | Hordeum vulgare subsp. Vulgare | 5LR8[A,B], 5LRA[A,B] | Plastidial α-1,4-glucan phosphorylase (Pho1; HvPho1) | GT-B | Dimer | [153] |
GT35 | ACJ76617.1 | Oryctolagus cuniculus | Dozens available-2GJ4[A] best solution | Glycogen phosphorylase (muscle) (PygM) | GT-B | Dimer | [225] |
GT35 | AAB68057.1 | Saccharomyces cerevisiae S288c | 1YGP[A,B] | Glycogen phosphorylase (Gph1; YPR160w) | GT-B | Dimer | [226] |
GT108 | CBZ24449.1 | Leishmania mexicana MHOM/GT/2001/U1103 | 6Q50[A] | MTP4 (LMXM_10_1260) | 5-fold β-propeller | Monomer | [174] |
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Li, A.; Benkoulouche, M.; Ladeveze, S.; Durand, J.; Cioci, G.; Laville, E.; Potocki-Veronese, G. Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases. Int. J. Mol. Sci. 2022, 23, 3043. https://doi.org/10.3390/ijms23063043
Li A, Benkoulouche M, Ladeveze S, Durand J, Cioci G, Laville E, Potocki-Veronese G. Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases. International Journal of Molecular Sciences. 2022; 23(6):3043. https://doi.org/10.3390/ijms23063043
Chicago/Turabian StyleLi, Ao, Mounir Benkoulouche, Simon Ladeveze, Julien Durand, Gianluca Cioci, Elisabeth Laville, and Gabrielle Potocki-Veronese. 2022. "Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases" International Journal of Molecular Sciences 23, no. 6: 3043. https://doi.org/10.3390/ijms23063043
APA StyleLi, A., Benkoulouche, M., Ladeveze, S., Durand, J., Cioci, G., Laville, E., & Potocki-Veronese, G. (2022). Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases. International Journal of Molecular Sciences, 23(6), 3043. https://doi.org/10.3390/ijms23063043