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Review Reports

Int. J. Mol. Sci.2022, 23(6), 3127;https://doi.org/10.3390/ijms23063127

by

Carlotta Bon¹,
Ting-Rong Chern² and
Elena Cichero³
et al.

Reviewer 1: Anonymous Reviewer 2: Anonymous

Round 1

Reviewer 1 Report

Dear authors,

thank you for the manuscript. It can be considered interesting for the Journal's readership. However I have some major points.

Please, provide detailed description of the AtomNet CNN and features that you used.
Could you please describe all possible pharmacological and side effects for TAAR5 antagonists? Are there any other efforts to find TAAR5 antagonists? it would be great to provide this information in the text.
What is the rationale under selection of ERK and CREB as the molecules, which were influenced by TAAR5 antagonists?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Please refer to the attached document

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.docx