Repositioning the Role of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) on the TRAIL to the Development of Diabetes Mellitus: An Update of Experimental and Clinical Evidence

Round 1

Reviewer 1 Report

I think the article is well-written and give us a comprehensive view on the role of TRAIL in diabetes mellitus, both in the view of experiment of in clinical settings. Therefore, I suggest that the manuscript may be published in present form after minor English revision.

Author Response

We thank the reviewer for the positive evaluation of our paper and for recommending "Acceptance". Since the reviewer suggested a minor English revision, we asked from a native English-speaking member of our research group to thoroughly screen the whole manuscript for possible grammatical errors and phrasing inconsistencies, and minor amendments were made. Changes are denoted with red color in the revised version of our manuscript. We would like to note that both reviewers provided excellent ratings for the language quality and writing style of our manuscript, so hopefully, any remaining language issues can be resolved in the proofreading process. 

Reviewer 2 Report

This article is very well written and points are clearly made. The authors do a good job of summarizing the relevant literature to present the effects of TRAIL on many different conditions in both animal and human models.

The only area of improvement would be the image quality of Figure 2. The font in this figure is fuzzy and distorted making most words difficult to read and some unreadable.

Author Response

We thank the reviewer for appreciating the comprehensiveness and scientific soundness of our work. We apologize for the poor readability of Figure 2, we had the limitation of inserting a high-resolution figure within a word manuscript. In response to the reviewer's comment, we adapted and resized Figure 2 in the revised version of our manuscript, so that the text is more easily readable, and we hope that with this adjustment, the image quality of Figure 2 has been significantly improved.