JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter pylori Infection and Contributes to Immune Escape and Gastric Carcinogenesis
, Wenqing Li 1,2,* and Raquel MejÃas-Luque 2,3,*
Round 1
Reviewer 1 Report
I was pleased to review the article “JAK-STAT1 signaling pathway is an early response to Helicobacter pylori infection and contributes to immune escape and gastric carcinogenesis”.
This work is important, with an interesting and useful hypothesis in pathophysiology of gastric cancer and, later, in prognosis of these patients.
The manuscript is clear, relevant for the field. The methodology used by the authors is appropriate for the purpose of the study and conclusions are narrowly linked to data discussion and available evidence.
The introduction is followed by the Results, I suggest to respect the classic structure of an article- introduction, materials and methods, results, discussion and conclusion (IMRAD). I make the same suggestion for the structure of the abstract- IMRAD.
In conclusion, I agree that this manuscript should be accepted for publication, after a review of the form of this article.
Reviewer 2 Report
The work of Xue Li and co-workers is well structured and appropriately describes their research. Excellent and explicit graphics / figures.It has an important scientific resonance STAT1 activation and PD-L1 expression in oncogenesis from chronic H. pylori infection. So it can be published.
