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Peer-Review Record

The Thousand Polish Genomes—A Database of Polish Variant Allele Frequencies

Int. J. Mol. Sci. 2022, 23(9), 4532; https://doi.org/10.3390/ijms23094532
by Elżbieta Kaja 1,2,3,†, Adrian Lejman 1,2,†, Dawid Sielski 1,2, Mateusz Sypniewski 1,4, Tomasz Gambin 5, Mateusz Dawidziuk 6, Tomasz Suchocki 7,8, Paweł Golik 9, Marzena Wojtaszewska 1,10, Magdalena Mroczek 11, Maria Stępień 1,12,13, Joanna Szyda 7,8, Karolina Lisiak-Teodorczyk 1, Filip Wolbach 1, Daria Kołodziejska 1, Katarzyna Ferdyn 1,14, Maciej Dąbrowski 1,15, Alicja Woźna 1,16, Marcin Żytkiewicz 17, Anna Bodora-Troińska 17, Waldemar Elikowski 17, Zbigniew J. Król 2, Artur Zaczyński 2, Agnieszka Pawlak 2,18, Robert Gil 2,18, Waldemar Wierzba 2, Paula Dobosz 1,2,19, Katarzyna Zawadzka 1, Paweł Zawadzki 1,16 and Paweł Sztromwasser 1,*add Show full author list remove Hide full author list
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Int. J. Mol. Sci. 2022, 23(9), 4532; https://doi.org/10.3390/ijms23094532
Submission received: 21 March 2022 / Revised: 13 April 2022 / Accepted: 14 April 2022 / Published: 20 April 2022
(This article belongs to the Special Issue State-of-the-Art Molecular Genetics and Genomics in Poland)

Round 1

Reviewer 1 Report

Overall the manuscript is well written and of scientific importance both from a population genetics point of view and from a biomedical point of view. 

I consider that some graphics need to be reformulated as are quite confusing and not self-explained as they should be.

Further comments are in the pdf file attached.  

 

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Reviewer 2 Report

The authors sequenced a large cohort of Polish population with great sequencing coverage. They genotyped different structural variants, mitochondrial haplotypes and performed Mendelian analyses. They also put the Polish results in context by comparing with other global populations.

The methods are well described and are standard. The limitations of the cohort are presented and discussed (not representative of the entire Polish population).

The work in this study represents a great resource, including genetic characterization of a Polish cohort, contributing with an open public database, with impact on the representation of diverse populations in human genomics and eventually with health-related research.

 

Minor concerns:

-It would be useful to clarify abbreviations of all populations used in the figure legends.

 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

The authors state several times “coverage” but they may mean “average read depth”. Please clarify

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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