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Communication

Streptozotocin-Induced Diabetes Causes Changes in Serotonin-Positive Neurons in the Small Intestine in Pig Model

1
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowski Str. 13, 10-718 Olsztyn, Poland
2
Department of Visceral, Transplant, Thoracic and Vascular Surgery, University of Leipzig Medical Center, Liebigstr. 21, 04103 Leipzig, Germany
3
Institute of Anatomy, University of Leipzig, Liebigstraße 13, 04103 Leipzig, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(9), 4564; https://doi.org/10.3390/ijms23094564
Submission received: 7 March 2022 / Revised: 19 April 2022 / Accepted: 19 April 2022 / Published: 20 April 2022
(This article belongs to the Special Issue Recent Research on Diabetes Mellitus and Its Complications)

Abstract

Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter of the central and peripheral nervous systems, predominantly secreted in the gastrointestinal tract, especially in the gut. 5-HT is a crucial enteric signaling molecule and is well known for playing a key role in sensory-motor and secretory functions in the gut. Gastroenteropathy is one of the most clinical problems in diabetic patients with frequent episodes of hyperglycemia. Changes in 5-HT expression may mediate gastrointestinal tract disturbances seen in diabetes, such as nausea and diarrhea. Based on the double immunohistochemical staining, this study determined the variability in the population of 5-HT-positive neurons in the porcine small intestinal enteric neurons in the course of streptozotocin-induced diabetes. The results show changes in the number of 5-HT-positive neurons in the examined intestinal sections. The greatest changes were observed in the jejunum, particularly within the myenteric plexus. In the ileum, both de novo 5-HT synthesis in the inner submucosal plexus neurons and an increase in the number of neurons in the outer submucosal plexus were noted. The changes observed in the duodenum were also increasing in nature. The results of the current study confirm the previous observations concerning the involvement of 5-HT in inflammatory processes, and an increase in the number of 5-HT -positive neurons may also be a result of increased concentration of the 5-HT in the gastrointestinal tract wall and affects the motor and secretory processes, which are particularly intense in the small intestines.
Keywords: serotonin; enteric nervous system; diabetes; pig serotonin; enteric nervous system; diabetes; pig

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MDPI and ACS Style

Bulc, M.; Palus, K.; Całka, J.; Kosacka, J.; Nowicki, M. Streptozotocin-Induced Diabetes Causes Changes in Serotonin-Positive Neurons in the Small Intestine in Pig Model. Int. J. Mol. Sci. 2022, 23, 4564. https://doi.org/10.3390/ijms23094564

AMA Style

Bulc M, Palus K, Całka J, Kosacka J, Nowicki M. Streptozotocin-Induced Diabetes Causes Changes in Serotonin-Positive Neurons in the Small Intestine in Pig Model. International Journal of Molecular Sciences. 2022; 23(9):4564. https://doi.org/10.3390/ijms23094564

Chicago/Turabian Style

Bulc, Michał, Katarzyna Palus, Jarosław Całka, Joanna Kosacka, and Marcin Nowicki. 2022. "Streptozotocin-Induced Diabetes Causes Changes in Serotonin-Positive Neurons in the Small Intestine in Pig Model" International Journal of Molecular Sciences 23, no. 9: 4564. https://doi.org/10.3390/ijms23094564

APA Style

Bulc, M., Palus, K., Całka, J., Kosacka, J., & Nowicki, M. (2022). Streptozotocin-Induced Diabetes Causes Changes in Serotonin-Positive Neurons in the Small Intestine in Pig Model. International Journal of Molecular Sciences, 23(9), 4564. https://doi.org/10.3390/ijms23094564

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