Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function
, Sergey S. Obernikhin 1, Dibakhan A. Tsomartova 1,2, Valentin V. Yaglov 1, Svetlana V. Nazimova 1, Elina S. Tsomartova 1,2, Ekaterina P. Timokhina 1, Elizaveta V. Chereshneva 2, Marina Y. Ivanova 2 and Tatiana A. Lomanovskaya 2Round 1
Reviewer 1 Report
In the current manuscript authors approached for the first time the investigation of potential damaging effects of prenatal (vs post natal) exposure to DDT on adrenal medulla development and function. The results of the study are original and relevant for those involved in developmental and environmental branches of medicine, as well as to many broader areas of research. The study is very well conceived although simple in design but provides strong evidence of a detrimental effects of DDT with poor adaptation later in life. Results are adequately presented and supported by proper discussion of available literature and explanation of potentially involved mechanisms and wider implications.
Author Response
We are very grateful for all your comments and attention to the manuscript!
Reviewer 2 Report
The work is good, interesting, and deserves publication.
Minor points can be improved. Epinephrine is shortly described, and its role. Develop in a few sentences.
In the abstract, give amounts of reduction, examples for decrease (%), like in the results. Please add also in abstract and discussion details on the hypothetic mechanism of action, direct or indirect, and why. Add in abstract the dysmorphogenetic action. Explain in discussion better. What other experiments are needed? You underline that low levels od DDT are used. PLease compare that to the environmental levels. This appears very important. Line 357, it is Bouin and not Bouen.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
