Fractone Stem Cell Niche Components Provide Intuitive Clues in the Design of New Therapeutic Procedures/Biomatrices for Neural Repair
Abstract
:1. Introduction
2. Neuroprogenitor Stem Cell Niches and the Cell Regulatory Environment Provided by ECM Components
3. Development of HA Hydrogel Cell Delivery and Therapeutic Biomatrices for Tissue Repair
Application of HA as a Delivery Vehicle for Olfactory Ensheathing Cells ± Mesenchymal Stem Cells from a Number of Tissues for Neural Repair
4. Application of HS Containing Biomatrices for Neural Repair
4.1. Harnessing Cell Instructive Properties of Perlecan’s HS Side Chains in Repair Biology
4.2. Development of Artificial Neural Stem Cell Niches
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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HA Hydrogel/Scaffold and Its Properties in Tissue Repair Processes | Ref | |
---|---|---|
Injectable HA hydrogel | MSC repair of infarcted myocardium. | [57] |
Tissue adhesive HA hydrogel | Sutureless stem cell delivery and regeneration of corneal epithelium and stroma. | [58] |
HA hydrogel | MSC delivery to damaged vocal cord. | [81] |
HA hydrogel | Treatment of Endometrial Injury in a Rat Model of Asherman’s Syndrome. | [60] |
Injectable HA hydrogel | Tunable HA hydrogels releasing chemotactic and angiogenic growth factors for endodontic regeneration. | [61] |
HA scaffold | Scaffolds that improve stem cell functions for tissue repair and regeneration. | [82] |
Interpenetrating collagen, HA, polymer networks | Scaffolds for brain tissue engineering. | [53] |
Injectable HA Scaffolds with Macroporous Architecture | Scaffold designed for gene delivery for tissue repair. | [67] |
Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres | Extended delivery of VEGF and BDNF from PGLA microspheres promotes neural growth. | [79] |
Divynyl sulfone crosslinked HA | Scaffolds with a range of pore sizes supporting cell migration and neurite extension. | [83] |
Neurotrophin NGF-HA hydrogel filler cell delivery system | Scaffold filler hydrogel used in combination with olfactory ensheathing cells to repair of a 10 mm gap model of sciatic nerve injury in Sprague–Dawley rats | [80] |
Biomimetic collagen, laminin, HA, and CS–proteoglycan biocomposites | Biomimetic hydrogels of collagen, laminin, HA, and CS-PGs developed to reproduce native ECM structure for the promotion of cell survival, neural differentiation, and neurite outgrowth. | [73] |
Electrospun HA–polycaprolactone nanofiber bioscaffolds | Electrospun high-porosity nanofibrous scaffolds suitable for the growth of SH-SY5Y human neuroblastoma cells. | [84] |
HA-poly-D-lysine hydrogel | Copolymer hydrogel with an open porous structure and viscoelastic properties similar to those of native brain tissue. Proposed as a promising scaffold for the repair of brain defects. | [78] |
HA–laminin hydrogels | HA–laminin hydrogels implanted into brain defects promoted neurite extension and inhibited glial scar formation. | [74] |
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Melrose, J. Fractone Stem Cell Niche Components Provide Intuitive Clues in the Design of New Therapeutic Procedures/Biomatrices for Neural Repair. Int. J. Mol. Sci. 2022, 23, 5148. https://doi.org/10.3390/ijms23095148
Melrose J. Fractone Stem Cell Niche Components Provide Intuitive Clues in the Design of New Therapeutic Procedures/Biomatrices for Neural Repair. International Journal of Molecular Sciences. 2022; 23(9):5148. https://doi.org/10.3390/ijms23095148
Chicago/Turabian StyleMelrose, James. 2022. "Fractone Stem Cell Niche Components Provide Intuitive Clues in the Design of New Therapeutic Procedures/Biomatrices for Neural Repair" International Journal of Molecular Sciences 23, no. 9: 5148. https://doi.org/10.3390/ijms23095148