Sulfatide Deficiency, an Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks
Abstract
:1. Introduction
2. Results
2.1. Mild Sulfatide Depletion Causes Brain Ventricular Enlargement
2.2. Adult-Onset CNS-Specific Sulfatide Deficiency Leads to Brain Ventricular Enlargement
2.3. Mild Sulfatide Deficiency and Ventricular Enlargement Observed in APOE4 Compared to APOE2 Knock-in Adult Mice
2.4. Sulfatide Deficiency Induces Ventricular Enlargement by Increasing AQP4 Expression
3. Discussion
4. Materials and Methods
4.1. Mice
4.2. Histology
4.3. Lipidomics
4.4. Brain MRI
4.5. Western Blot
4.6. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Palavicini, J.P.; Ding, L.; Pan, M.; Qiu, S.; Wang, H.; Shen, Q.; Dupree, J.L.; Han, X. Sulfatide Deficiency, an Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks. Int. J. Mol. Sci. 2023, 24, 233. https://doi.org/10.3390/ijms24010233
Palavicini JP, Ding L, Pan M, Qiu S, Wang H, Shen Q, Dupree JL, Han X. Sulfatide Deficiency, an Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks. International Journal of Molecular Sciences. 2023; 24(1):233. https://doi.org/10.3390/ijms24010233
Chicago/Turabian StylePalavicini, Juan Pablo, Lin Ding, Meixia Pan, Shulan Qiu, Hu Wang, Qiang Shen, Jeffrey L. Dupree, and Xianlin Han. 2023. "Sulfatide Deficiency, an Early Alzheimer’s Lipidomic Signature, Causes Brain Ventricular Enlargement in the Absence of Classical Neuropathological Hallmarks" International Journal of Molecular Sciences 24, no. 1: 233. https://doi.org/10.3390/ijms24010233