IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases

Borgia, Francesco; Custurone, Paolo; Li Pomi, Federica; Vaccaro, Mario; Alessandrello, Clara; Gangemi, Sebastiano

doi:10.3390/ijms24010372

Open AccessReview

IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases

by

Francesco Borgia

^1,*

,

Paolo Custurone

¹

,

Federica Li Pomi

¹

,

Mario Vaccaro

¹

,

Clara Alessandrello

²

and

Sebastiano Gangemi

²

¹

Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, 98125 Messina, Italy

²

Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(1), 372; https://doi.org/10.3390/ijms24010372

Submission received: 24 November 2022 / Revised: 21 December 2022 / Accepted: 23 December 2022 / Published: 26 December 2022

(This article belongs to the Special Issue Recent Advances in Skin Disease and Comorbidities)

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Abstract

Interleukin (IL)-37 and IL-33 are among the latest cytokines identified, playing a role in several inflammatory conditions, spanning from systemic conditions to tumors to localized diseases. As newly discovered interleukins, their role is still scarcely understood, but their potential role as therapeutic targets or disease activity markers suggests the need to reorganize the current data for a better interpretation. The aim of this review is to collect and organize data produced by several studies to create a complete picture. The research was conducted on the PubMed database, and the resulting articles were sorted by title, abstract, English language, and content. Several studies have been assessed, mostly related to atopic dermatitis and immunologic pathways. Collective data demonstrates a pro-inflammatory role of IL-33 and an anti-inflammatory one for IL-37, possibly related to each other in an IL-33/IL-37 axis. Although further studies are needed to assess the safety and plausibility of targeting these two interleukins for patients affected by skin conditions, the early results indicate that both IL-33 and IL-37 represent markers of disease activity.

Keywords: IL-37; IL-33; skin; allergic diseases; inflammation; interleukin; atopic dermatitis; psoriasis; asthma; contact dermatitis

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MDPI and ACS Style

Borgia, F.; Custurone, P.; Li Pomi, F.; Vaccaro, M.; Alessandrello, C.; Gangemi, S. IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases. Int. J. Mol. Sci. 2023, 24, 372. https://doi.org/10.3390/ijms24010372

AMA Style

Borgia F, Custurone P, Li Pomi F, Vaccaro M, Alessandrello C, Gangemi S. IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases. International Journal of Molecular Sciences. 2023; 24(1):372. https://doi.org/10.3390/ijms24010372

Chicago/Turabian Style

Borgia, Francesco, Paolo Custurone, Federica Li Pomi, Mario Vaccaro, Clara Alessandrello, and Sebastiano Gangemi. 2023. "IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases" International Journal of Molecular Sciences 24, no. 1: 372. https://doi.org/10.3390/ijms24010372

APA Style

Borgia, F., Custurone, P., Li Pomi, F., Vaccaro, M., Alessandrello, C., & Gangemi, S. (2023). IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases. International Journal of Molecular Sciences, 24(1), 372. https://doi.org/10.3390/ijms24010372

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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IL-33 and IL-37: A Possible Axis in Skin and Allergic Diseases

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