High-Affinity Antibodies Designing of SARS-CoV-2 Based on Molecular Dynamics Simulations
Round 1
Reviewer 1 Report
The work titled “High-Affinity Antibodies Designing of SARS-CoV-2 Based on
Molecular Dynamics Simulations” submitted by the authors is a very good in silico design of SARS-CoV-2 antibodies. In the given context, this could be a very good reference study for future antibody design against any known pathogen. The molecular dynamic simulation was performed well. I suggest to publish this work.
Author Response
Thanks for the reviewer's comments. Please see the response in the attachment.
Author Response File: Author Response.docx
Reviewer 2 Report
· English should be improved.
· Line 52-53 “as well as the high infection rate lead to the risky of physiological experiments” is not clear to the reader.
· Add an image showing the hydrogen bonding discussed in line 91-97 and 119-128.
· Figure 8 has legend error.
· Conclusion typing error
Author Response
Thanks for the reviewer's comments. Please see the reponse in the attachment.
Author Response File: Author Response.docx