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Volume 24
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Article

Effects of Chicken Serum Metabolite Treatment on the Blood Glucose Control and Inflammatory Response in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats

by
Xuan Hu
,
Xueming Liu
,
Yujiao Guo
,
Yi Li
,
Zhengfeng Cao
,
Yu Zhang
,
Yang Zhang
,
Guohong Chen
and
Qi Xu
*
Jiangsu Key Laboratory for Animal Genetic, Breeding and Molecular Design, Yangzhou University, Yangzhou 225009, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(1), 523; https://doi.org/10.3390/ijms24010523
Submission received: 12 October 2022 / Revised: 3 December 2022 / Accepted: 22 December 2022 / Published: 28 December 2022
(This article belongs to the Topic Animal Models of Human Disease)
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Abstract

Chickens can live healthy without adverse effects despite high blood glucose levels. However, the blood biomolecules responsible for maintaining chronic hyperglycemia are unknown. Here, the effects of chicken serum metabolite treatment on blood glucose control and inflammatory response in streptozotocin (STZ)-induced Type 2 Diabetes Mellitus (T2DM) rats were investigated. First, chicken serum treatment reduced the advanced glycation end-products (AGEs) and blood glucose levels in STZ-induced T2DM rats. Second, insulin/glucose-induced acute hypoglycemic/hyperglycemic chickens and the blood biomolecules were screened via nontargeted ultra-performance liquid chromatography with mass spectroscopy (UPLC-MS), identifying 366 key metabolites, including DL-arginine and taurine, as potential markers for chronic hyperglycemia in chickens. Finally, DL-arginine functions for blood glucose control and inflammatory response were evaluated. We found that DL-arginine reduced the levels of blood glucose and AGEs in STZ-induced T2DM rats. In addition, DL-arginine treatment upregulated the glucose transporter type 4 (GLUT4) expression in the muscles and downregulated the advanced glycation end products receptor-1 (AGER1) expression in the liver and nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) expression in the pancreas and thymus tissues. Overall, these results demonstrate that serum metabolite of DL-arginine could maintain blood glucose homeostasis and suppress the inflammatory response in chickens. Therefore, DL-arginine may be a novel target for developing therapeutic agents to regulate hyperglycemia.
Keywords: chicken; streptozotocin-induced rats; DL-arginine; blood glucose; inflammatory response chicken; streptozotocin-induced rats; DL-arginine; blood glucose; inflammatory response

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MDPI and ACS Style

Hu, X.; Liu, X.; Guo, Y.; Li, Y.; Cao, Z.; Zhang, Y.; Zhang, Y.; Chen, G.; Xu, Q. Effects of Chicken Serum Metabolite Treatment on the Blood Glucose Control and Inflammatory Response in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats. Int. J. Mol. Sci. 2023, 24, 523. https://doi.org/10.3390/ijms24010523

AMA Style

Hu X, Liu X, Guo Y, Li Y, Cao Z, Zhang Y, Zhang Y, Chen G, Xu Q. Effects of Chicken Serum Metabolite Treatment on the Blood Glucose Control and Inflammatory Response in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats. International Journal of Molecular Sciences. 2023; 24(1):523. https://doi.org/10.3390/ijms24010523

Chicago/Turabian Style

Hu, Xuan, Xueming Liu, Yujiao Guo, Yi Li, Zhengfeng Cao, Yu Zhang, Yang Zhang, Guohong Chen, and Qi Xu. 2023. "Effects of Chicken Serum Metabolite Treatment on the Blood Glucose Control and Inflammatory Response in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats" International Journal of Molecular Sciences 24, no. 1: 523. https://doi.org/10.3390/ijms24010523

APA Style

Hu, X., Liu, X., Guo, Y., Li, Y., Cao, Z., Zhang, Y., Zhang, Y., Chen, G., & Xu, Q. (2023). Effects of Chicken Serum Metabolite Treatment on the Blood Glucose Control and Inflammatory Response in Streptozotocin-Induced Type 2 Diabetes Mellitus Rats. International Journal of Molecular Sciences, 24(1), 523. https://doi.org/10.3390/ijms24010523

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