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Peer-Review Record

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)

Int. J. Mol. Sci. 2023, 24(1), 577; https://doi.org/10.3390/ijms24010577
by Gehan Botrus 1,2, Richard M. Miller 2, Pedro Luiz Serrano Uson Junior 3, Geoffrey Kannan 4, Haiyong Han 5,6 and Daniel D. Von Hoff 6,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(1), 577; https://doi.org/10.3390/ijms24010577
Submission received: 23 November 2022 / Revised: 23 December 2022 / Accepted: 24 December 2022 / Published: 29 December 2022
(This article belongs to the Special Issue Study of Endoplasmic Reticulum Stress and Unfolded Protein Response)

Round 1

Reviewer 1 Report

This is a very good review, which can be published with appropriate language embellishment.

Author Response

Please see the attachment. Thank you.

Author Response File: Author Response.pdf

Reviewer 2 Report

A review from Botrus et al. talks about the role of endoplasmic reticulum stress and unfolded protein response on pancreatic cancer cell apoptosis. The review is nicely written and can be elaborated to attract a broad audience by incorporating the following points.

 

1.    Pancreatic acinar cells are synthetically very active and are prone to ER stress. Authors should also include a section explaining the role of inflammation (pancreatitis) induced stress in chronic pancreatitis and its development into pancreatic cancer.

2.    The authors should also describe in little detail the genetically engineered mouse models used to analyze ER stress in pancreatic cancer and pancreatitis.

3.    Multiple examples or studies should explain the vital or recent information wherever discussed in the text.

Author Response

Please see the attachment. Thank you.

Author Response File: Author Response.pdf

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