Relationship between the Reduced Expression of Zinc Finger Protein 668 in Bladder Cancer and Its Invasiveness
Abstract
:1. Introduction
2. Results
2.1. Immunohistochemistry
2.2. Structural Analysis of the ZNF668 Gene
3. Discussion
4. Materials and Methods
4.1. Immunohistochemistry
4.2. Structural Analysis of the ZNF668 Gene
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Submucosal Invasion | |||
---|---|---|---|
Plus | Minus | p-Value | |
IRS | 4.34 ± 2.16 | 6.68 ± 3.23 | 0.0007 |
muscle invasion | |||
plus | minus | ||
IRS | 3.46 ± 2.51 | 6.20 ± 2.92 | 0.0026 |
rs2303222 (Exon1) | rs2303223 (Exon2) | Somatic Mutation (Exon3) | |||||||
---|---|---|---|---|---|---|---|---|---|
G/G (n = 60) | G/A (n = 4) | p-Value | A/A (n = 61) | A/G (n = 5) | p-Value | No (n = 61) | Yes (n = 4) | p-Value | |
IRS | 5.88 ± 2.73 | 5.50 ± 4.81 | 0.8860 | 5.89 ± 2.80 | 6.40 ± 4.63 | 0.8202 | 5.96 ± 2.85 | 3.88 ± 1.65 | 0.0830 |
submucosal invasion | 44.6% | 25.0% | 0.6261 | 42.1% | 20.0% | 0.6398 | 42.1% | 50.0% | 1.0000 |
muscle invasion | 21.4% | 25.0% | 1.0000 | 21.1% | 20.0% | 1.0000 | 19.3% | 50.0% | 0.1963 |
DNA Changes | Protein Changes | Mean_IRS | |
---|---|---|---|
pT1≤ | pT2≤ | ||
Case A | c.825C>T + | synonymous − | 10.5 |
Case B | c.[910G>T(;)916_931delinsGGAGCTTGGGCATCAA] − | p.[G298T(;)G304_E311delinsWVGAWASK] − | 4.0 |
Case C | c.1339G>C + | p.A447P + | 1.5 |
Case D | c.1556G>T − | p.Q515H − | 5.0 |
Case E | c.[1781A>G(;)1974C>T(;)2028C>G] + | p.H594R + | 5.0 |
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Okuno, Y.; Hattori-Kato, M.; Tanaka, H.; Tonooka, A.; Takeuchi, T. Relationship between the Reduced Expression of Zinc Finger Protein 668 in Bladder Cancer and Its Invasiveness. Int. J. Mol. Sci. 2023, 24, 8668. https://doi.org/10.3390/ijms24108668
Okuno Y, Hattori-Kato M, Tanaka H, Tonooka A, Takeuchi T. Relationship between the Reduced Expression of Zinc Finger Protein 668 in Bladder Cancer and Its Invasiveness. International Journal of Molecular Sciences. 2023; 24(10):8668. https://doi.org/10.3390/ijms24108668
Chicago/Turabian StyleOkuno, Yumiko, Mami Hattori-Kato, Hiroki Tanaka, Akiko Tonooka, and Takumi Takeuchi. 2023. "Relationship between the Reduced Expression of Zinc Finger Protein 668 in Bladder Cancer and Its Invasiveness" International Journal of Molecular Sciences 24, no. 10: 8668. https://doi.org/10.3390/ijms24108668