Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 Inhibition
Abstract
:1. Introduction
2. CDKs and Cell Cycle
3. LncRNAs and Cell Cycle
3.1. LncRNA Profile
3.2. Cell Cycle Regulated by LncRNAs
4. MiRNAs and Cell Cycle
4.1. MiRNA Profile
4.2. Cell Cycle Regulated by MiRNAs
5. NcRNAs and CDKI Treatment
5.1. CDKIs and Cancer Treatment
5.2. LncRNA and CDKI Clinical Efficiency
5.3. MiRNA and CDKI Clinical Efficiency
6. Perspective and Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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LncRNA | Target in Cell Cycle (Phase) | Deregulation in Cancer | References |
---|---|---|---|
MEG3 | Promotion of p27 by miR-3163/Skp2 mRNA translation. | Downregulated in BLCA, BRCA, CCA, COCA, OVCA. Upregulated in small cell lung cancer. | [88] |
LINC-PINT | Suppression of CDK1 and cyclin A2 with PRC2 and EZH2 (G2/M). | Downregulated in HCC, BLCA, BRCA, MM, T and B-ALL. Upregulated in COCA. | [75,76] |
HEIH | Suppression of p15, p16, p21 and p57 with EZH2 (G0/G1). | Upregulated in HCC. Downregulated in BRCA, CRCA, OVCA, PRCA. | [77] |
ANRIL | Suppression of p21, p14, p15, p16 upregulated cyclin G1 by targeting miR-181a-5p (G0/G1, G2/M). | Upregulated in glioma, LSCC, GC, EOC, HNSC, NSCLC, ESCC, CRCA. | [78,79,80] |
LINC00630 | Promotion of CDK2 transcription (S). | Upregulated in HCC, CRCA. | [84] |
ZFAS1 | Promotion of p21 and p27 expression; destabilization of p53; promotion of CDK1/cyclin B1 complex by interaction (G1/S). | Upregulated in CRCA, BLCA, GC, HCC, PRCA. Downregulated in OVCA, basal-like BRCA. | [94] |
TMPO-AS1 | Promotion of CDK1. Promotion proliferation by sponging miR-326 and targeted by E2F1 (G0/G1, G2/M). | Upregulated in BLCA, basal-like BRCA, CCA, CRCA, LUCA, PRCA, HCC, OVCA. | [82] |
ARAP1-AS1 | Promotion of cyclin D1 (G0/G1). | Upregulated in LUCA. | [85] |
CADM1-AS1 | Promotion of p15, p21, p27. Suppression of cyclin Ds, cyclin Es, CDK2, CDK4, CDK6 (G0/G1). | Downregulated in HCC. | [95] |
TPT1-AS1 | Promotion of CDK4, cyclin D1, suppression of p21 (G1/S). | Upregulated in GC, HCC. Downregulated in BLCA, BRCA, LUCA, OVCA, PRCA. | [89] |
ABHD11-AS1 | Promotion of Cyclin D1, cyclin E1, CDK1, CDK2, CDK4. Suppression of p16 (G1/S). | Upregulated in EC, PCA, GC, LUCA. Downregulated in CRCA. | [90,91,92,93] |
CCDC144NL-AS1 | Promotion of CDK1, CKD2 and CDK4 (G0-1/S) through miR-940/WDR5. | Upregulated in CRCA, HCC. Downregulated in LUCA. | [99] |
LINC00261 | Co-regulation with CDK1 (G0/G1; G2/M). | Downregulated in choriocarcinoma, HCC, BRCA, PRCA, CRCA, GC, LUCA. | [83] |
Gadd7 | Suppression of CDK6 mRNA degradation (G1/S). | Induced by DNA damage and oxidative stress. | [96,97] |
ALMS1- IT1 | ALMS1-IT1/AVL9 promote CDK pathway. | Upregulated in small cell lung cancer, CCA, CRCA, OVCA. Downregulated in LUCA. | [86] |
XIST | Promotion of cyclin D1, CDK1 and p53, suppression of p21 (G1). Suppression of Wee1 (G2). | Upregulated in PCA, CRCA, ESCC. Downregulated in OVCA, NSCLC, HCC, BRCA, BLCA. | [63,98] |
ENST00000512916 | Promotion of CDK2/4/6 and cyclin D1 (G1). | Upregulated in AB. | [87] |
TROJAN | Promotion of CDK2. | Upregulated in ER-positive BRCA. | [100] |
SNHG15 | Promotion of CDK6 by miR-627 sponging. | Upregulated in BLCA, TNBC, CRCA, GC, LUCA, PRCA. | [101] |
miRNA | Target in Cell Cycle (Phase) | Deregulation in Cancer | References |
---|---|---|---|
miR-195 | Suppression of CDK6, cyclin E1, CDK4, cyclin D1, cyclin D3 (G1/S). | Downregulated in NSCLC, GC, HCC, BLCA. Upregulated in BRCA, CLL, ACA. | [126,127] |
miR-100 | Targeting and suppressing PLK1; suppression of reduced β-tubulin I, IIA, IIB and V mRNA; suppression of p27 (G2/M). | Upregulated in BRCA, PCA. Downregulated in PRCA, OVCA, BLCA. | [128,129] |
miR-365 | Suppression cyclin D1 and CDC25A, promotion of p27 (G1/S). | Downregulated in NSCLC, BRCA, OVCA. | [130,131] |
miR-15a | Suppression of CDK1, CDK2, CDK6, cyclin D1, cyclin D2 and cyclin E1 (G1/S). | Downregulated in HCC, BRCA, OS, NSCLC, PCA, PRCA. Upregulated in CLL. | [132,133,134,135] |
miR-16 | Suppression of CDK1, CDK2, CDK6, cyclin D1, cyclin D2 and cyclin E1 (G1/S). | Downregulated in PRCA, GC, LUCA. Upregulated in PCA, HCC. | [133,134,135] |
Let-7 | Suppression of CDK4, Cyclin D1, cyclin D3, Cyclin A and Cyclin B translation (G1). | Downregulation in OVCA, LUCA, NSCLC, BRCA, CRCA, PRCA, HNSC. | [136,137,138,139] |
miR-7 | Suppression of p53, CDC42, Cyclin D, cyclin E1 (G0-1/S). | Downregulated in BRCA, CCA, MG, HCC. Upregulated in HNSC, LUCA. | [136,140,141] |
miR-19 | Suppression of Cyclin Ds, promotion of p21 (G1/S). | downregulated in MG. | [142,143] |
miR-20a | Suppression of E2F2 and E2F3 translation; Suppression cyclin D1 mRNA transcription; Suppression of p21 (G1/S). | Upregulated in HCC, CRCA, PRCA, PCA, LUCA. Downregulated in BRCA, HCC. | [144,145,146] |
miR-34 | Suppression of Cyclin D1, CDK4, CDK6 translation; promotion of p21 (G1/S). | Downregulated in PCA, OVCA, NSCLC, HCC. Upregulated in CRCA. | [147,148] |
miR-124a | Suppression CDK2, CDK6, cyclin D1, cyclin D2 translation (G1). | Downregulated in all cancer. | [149,150,151] |
miR-125b | Suppression cyclin D1, CDK6, promotion of p21 (G1/S). | Downregulated in PRCA, LUCA, HCC, BRCA, CCA, CRCA. Upregulated in PCA, BLCA. | [152,153,154] |
miR-24 | Suppression of p27, p16, p21(G2/M). | Downregulated in PRCA, PTC. Upregulated in LUCA, PCA, CRCA. | [154,155] |
miR-26a | Suppression of cyclin D2, cyclin D3, cyclin E2, CDK4/6; promotion of p14. | Downregulated in PTC, LUCA, HCC, BRCA, BLCA. | [156,157,158] |
miR-101 | Suppression of CDK2, CDK4, CDK6, cyclin D2, cyclin D3 and cyclin E2; Promotion of p14, p16, p21 and p27 (G1). | Downregulated in LUCA, PRCA, HCC, LSCC, OVCA, BLCA. | [159,160] |
miR-9 | Suppression of CDK6, cyclin D1; promotion p16 (G0/G1). | Downregulated in HSCC. | [161,162,163] |
miR-218 | Suppression CDK6, cyclin D1; promotion of p14, p16. | Downregulated in MG, LUCA, CCA. Upregulated in PRCA. | [164,165] |
miR-210 | Suppression of CDK4, CDK6; promotion of p27 (G1/S). | Upregulated in PRCA, LUCA, PCA, HNSC, BRCA. | [166] |
miR-17-5p | Suppression of cyclin D1; promotion of p21 (G2/M). | Upregulated in bladder cancer, HCC, BRCA, CRCA, LUCA. | [144,167,168,169] |
miR-17-92 cluster (MIR17HG) | Suppression of E2F1, cyclin D1. Promotion of p21 (G1/S). | Upregulated in BL, CRCA, LUCA, BLCA, BRCA, PRCA, PCA, HCC. | [170,171,172,173,174,175,176] |
miR-106a | Suppression of p21, cyclin D1 (G1/S). | Upregulated in LUCA, HCC, PCA, PRCA, CRCA. | [143,177] |
miR-106b | Suppression of cyclin D1, E2F1, p21 (G1/S). | upregulated in HCC, GC, CRCA. Downregulated in OVCA. | [172,178,179,180] |
miR-330 | Suppression of E2F1. | Downregulated in OSCC, PRCA. | [181] |
miR-331-3p | Suppression of E2F1. | Downregulated in HNSC, OSCC. Upregulated in AML. | [182] |
miR-449 | Promotion of CDK6 and CDC25A; Suppression E2F1, E2F3, cyclin D1, cyclin A2. | Downregulated in PRCA. | [183,184] |
miR-31 | Suppression of CDK1, CDK4, CDK6; promotion of p21. | Upregulated in HNSC, CRCA, OSCC, LUCA. Downregulated in PRCA, BRCA, BLCA. | [185,186,187,188] |
miR-512-5p | Suppression of p21. | Downregulated in GC. | [189] |
miR-370 | Promotion of p27 and p21 (G1/S). | Upregulated in PRCA. Downregulated in OSCC. | [190] |
miR-212 | Promotion of p21 and p27; suppression cyclin D3 (G1/S). | Upregulated in LUCA, PCA, HCC. | [191,192] |
miR-196a | Suppression of p27. | Upregulated in BRCA, PDAC, ESCC, CRCA. | [193] |
miR-3163 | Promotion of p27 (G0/G1). | Downregulated in BRCA. | [88,194] |
miR-221 | Suppression of p27 and p57, promotion of CDK2 (G2/M). | Downregulated in PRCA, NSCLC. Upregulated in HCC, PCA, BLCA, CRCA, OVCA, BRCA, OSCC. | [195,196] |
miR-222 | Suppression of p27 (G1/S). | Downregulated in PRCA. Upregulated in PCA, NSCLC, HCC, GC. | [197,198,199] |
Nc886 | Promotion of CDKN2A and CDKN2C, suppression of CDK4 (G1/S). | Downregulated in ESCC, GC, PRCA. | [200,201] |
miR-29b-3p | Suppression of CDK6 (G1). | Downregulated in PRCA, LUCA, HNSC, CLL, AML. Upregulated in BRCA, CRCA, PCA. | [202,203] |
miR-497 | Suppression of CDK6, E2F3 and cyclin E1 (G1). | Downregulated in PRCA, LUCA, CRCA, BRCA. | [204,205] |
miR-193b | Suppression of cyclin D1 by targeting 3′UTR of mRNA (G1/S). | Downregulated in BRCA, PRCA, OS, MM. | [206,207,208,209] |
miR-200 | Suppression of CDK6 (G1). | Downregulated in CRCA, HCC, OV, BRCA, MM (all cancer) | [210] |
miR-206 | Suppression of CDK4, cyclin D1, cyclin C translation (G1). | Downregulated in BRCA, OVCA. | [211,212] |
miR-223 | Suppression of p21, p27 (G1). E2F1 binds to the miR-223 promoter and inhibits transcription. | Downregulated in AML, HCC, CLL. Upregulated in BLCA, PCA, CRCA, PRCA. | [213,214] |
ncRNA | Tumor Type | CDKIs | Sample | Function and Mechanism | References |
---|---|---|---|---|---|
MEG3 | LC | Palbociclib | cell lines | Palbociclib increase MEG3 expression. Silencing MEG3 expression rescue palbociclib-mediated decrease in cell proliferation. | [281] |
TROJAN | ER-positive BC, TNBC | Palbociclib | cell lines | TROJAN inhibit NKRF/RELA and upregulate CDK2 expression, which promote cell proliferation and resistance to a CDK4/6 inhibition in ER+ breast cancer. | [100] |
SNHG15 | GBM, BC, LC, HCC | Palbociclib | cell lines | SNHG15 upregulated CDK6 by sponging inhibit miR-627-5p. palbociclib treatment increased miR-627-5p expression and reduced SNHG15 and CDK6 expression. | [101] |
miR-3613-3p | BC | Palbociclib | clinical samples; PDTX; cell lines | MiR-3613-3p induce G1 cell cycle arrest and enhance TNBC sensitivity to palbociclib. | [282] |
miR-29b-3p | HER-negative BC | Palbociclib | clinical samples; PDTX; cell lines | MiR-29b downregulate CDK6 and induce cell cycle arrest at G1 phase. Activated c-Myc downregulate miR-29b, further activate CDK6 and resistance to palbociclib. | [203] |
miR-497 | ALCL | Palbociclib | cell lines | Hypermethylation repressed miR-497 expression. miR-497 inhibited CDK6, E2F3 and cyclin E1 (G1) caused cell cycle arrest. higher miR-497 expression cell more sensitive to palbociclib | [205] |
miR-193b | PCA | Palbociclib | cell lines | MiR-193b downregulate cyclin D1 by targeting 3′UTR of mRNA. palbociclib has no effect on cells with high miR-193b expression. | [209] |
miR-200a | MM | Palbociclib | cell lines | MiR-200 reduces CDK6 expression and reduces melanoma response to palbociclib. | [210] |
miR-223 | lum BC; HER2-positive BC | Palbociclib | transgenic mouse model; clinical samples; cell lines | Palbociclib restrain E2F1 activity and restore miR-223 expression. miR-223 deficiency induces luminal breast cancer resistance to palbociclib. | [283] |
miR-126 | lum BC; HER2-positive BC | Ribociclib | cell lines. | MiR-126 targets PI3K/AKT/MTOR pathway, affects cell cycle and mitosis. miR-125 preserving leukemia stem cell quiescence and promoting chemotherapy resistance. | [284] |
MIR17HG | GBM, AT/RT | Palbociclib; Ribociclib | cell lines | MIR17HG reduce cyclin D1 expression and sensitizes ATRT cells to palbociclib treatment. | [173] |
miR-432-5p | ER-positive BC | palbociclib; Ribociclib | cell lines | Palbociclib resistant cells increased miR-432-5p and CDK6 expression. In palbociclib resistance breast cancers, miR-432-5p is higher expressed. | [285] |
miR-9 | HER2-positive BC; TNBC | Ribociclib; | cell lines | Suppression of CDK6 and enhance the activity of ribociclib. | [284] |
miR-326 | HER2-positive BC | Ribociclib | cell lines | Suppression of CDK6 and enhance the activity of ribociclib. | [82] |
miR-124a | ALL | Palbociclib; PD-0332991 | cell lines | MiR-124a was down-regulated in ALL by hypermethylation of the promoter and histone modifications. MiR-124 negatively regulates CDK6 and pRB. ALL patients with overexpressed miR-124a benefit from CDK6 inhibition. | [149] |
miR-9 | ALL | Palbociclib | cell lines | Epigenetic downregulation of MIR9 induced upregulation of CDK6. | [174] |
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Hu, Q.; Huang, T. Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 Inhibition. Int. J. Mol. Sci. 2023, 24, 8939. https://doi.org/10.3390/ijms24108939
Hu Q, Huang T. Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 Inhibition. International Journal of Molecular Sciences. 2023; 24(10):8939. https://doi.org/10.3390/ijms24108939
Chicago/Turabian StyleHu, Qingyi, and Tao Huang. 2023. "Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 Inhibition" International Journal of Molecular Sciences 24, no. 10: 8939. https://doi.org/10.3390/ijms24108939
APA StyleHu, Q., & Huang, T. (2023). Regulation of the Cell Cycle by ncRNAs Affects the Efficiency of CDK4/6 Inhibition. International Journal of Molecular Sciences, 24(10), 8939. https://doi.org/10.3390/ijms24108939