Catechins and Proanthocyanidins Involvement in Metabolic Syndrome
Abstract
:1. Introduction
2. Metabolic Syndrome (MetS)
3. Chemical Structure and Classification of Flavonoids
3.1. Bioavailability of Catechin and Their Polymeric Structures
3.2. Biochemical and Functional Aspects of Catechin and Their Polymers
4. Catechins in Metabolic Syndrome
5. Proanthocyanidins in Mets
6. Human Studies
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Flavanols | Molecular Targets | Cell Culture | Dose | References |
---|---|---|---|---|
EC | Stimulated mitochondrial biogenesis | Mouse skeletal muscle | 3–10 μM | [80] |
Reduced release of the cytochrome c | Isolated rat heart mitochondria | 0.23 µg/mL and 0.46 µg/mL | [81] | |
Decreased NOX3/NOX4 liver expression and mitigated oxidative stress | C57BL/6J mice | 0 mg EC/kg | [84] | |
Modulated NOX subunit expression and directly inhibit NOX. Mitigated HFr-induced insulin resistance | Rat model | 20 mg EC/kg | [85,86] | |
Stimulated the cell membrane dissociation and activation of eNOS | Human coronary artery endothelial cells | 1 μmol/L | [87] | |
Regulated glucose metabolism through IRβ receptor and IRS-1/PI3K/Akt pathway | IR-HepG2 cells | 0–250 μg/mL | [88] | |
EGCG | Attenuated oxidative damage | Male Wistar rats | 20 mg/kg | [83] |
Enhanced the expression of SOD | Mice | 6.9 mg/kg | [67] | |
Increased the gene expression of SOD1,2, CAT, and GPx | IMR90 (HDF) cells | 25–50 μM | [68] | |
Increased SOD activity | Male rats | 50 mg/kg/d | [71] | |
Activated the Nrf2/ARE signaling pathway | Normal Rat Kidney Epithelial Cells (NRK-52E) cell | 5 μM | [89] | |
Reduced Akt phosphorylation/activation | Human pancreatic cancer cell line PANC-1 | 0 to 20 μM | [90] | |
Promoted GLUT4 translocation via activation of PI3K/Akt signaling pathway | Rat skeletal muscle L6 cell | 50 μM | [91] | |
Downregulated the ROS-ERK/JNK-p53 pathway and improved glucose homeostasis | Goto–Kakizaki (GK) rat | 100 mg/kg/d | [92] | |
Suppressed hepatic gluconeogenesis through 5′-AMP-activated protein kinase | Isolated hepatocytes | ≤1 μm | [93] | |
Inhibited glucose production | H4IIE rat hepatoma cells | 25 μM | [94] | |
EGCG + EGC | Reduced intestinal SGLT-1/GLUT2 ratio and enhanced adipose GLUT4 | Male Wistar rats | 4 mg EGCG+2 mg EGC | [95] |
ECG | Attenuated the ROS level | RAW 264.7 cells | 10 μM | [72] |
PCAs | Upregulated SOD, CAT, GPx, and hemeoxygenase-1 (HO-1) | Kunming Mice Liver | 100 mg/kg | [96] |
Activated the NO/cGMP pathway | Rat mesenteric arterial | 0.1–100 μg/mL | [97] | |
Increased GSH levels and reduced lipid peroxidation and total nitrite and nitrate levels | Wistar rats | 50 and 100 mg kg−1 | [98] | |
Decreased blood glucose level, increased insulin level through regulation of the PI3K signaling pathway | Male albino rats | 300 mg/kg/day | [99] | |
Activated the PI3K/AKT pathway | Albino Wistar rats | 100 mg/kg | [100] | |
Activated AMPK, Sirt1, and PGC-1α | Male BALB/c mice | 100 and 200 mg/kg | [101] | |
Activated the Nrf2 pathway | Wistar rats | 250 mg/kg | [102] | |
Procyanidins | Reduced ROS formation, increased SOD, CAT, GPx activity; regulated MAPK kinase pathway | Sprague-Dawley (SD) rat | 10–50 mg/kg | [103] |
Reduced the blood glucose level, PEPCK, and G6Pase | C57BL/6 male mice | 10 mg/kg | [104] |
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Patanè, G.T.; Putaggio, S.; Tellone, E.; Barreca, D.; Ficarra, S.; Maffei, C.; Calderaro, A.; Laganà, G. Catechins and Proanthocyanidins Involvement in Metabolic Syndrome. Int. J. Mol. Sci. 2023, 24, 9228. https://doi.org/10.3390/ijms24119228
Patanè GT, Putaggio S, Tellone E, Barreca D, Ficarra S, Maffei C, Calderaro A, Laganà G. Catechins and Proanthocyanidins Involvement in Metabolic Syndrome. International Journal of Molecular Sciences. 2023; 24(11):9228. https://doi.org/10.3390/ijms24119228
Chicago/Turabian StylePatanè, Giuseppe Tancredi, Stefano Putaggio, Ester Tellone, Davide Barreca, Silvana Ficarra, Carlo Maffei, Antonella Calderaro, and Giuseppina Laganà. 2023. "Catechins and Proanthocyanidins Involvement in Metabolic Syndrome" International Journal of Molecular Sciences 24, no. 11: 9228. https://doi.org/10.3390/ijms24119228