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Review

Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies

by
Yuriy M. Kositsyn
1,2,3,4,
Murilo S. de Abreu
5,
Tatiana O. Kolesnikova
1,2,3,6,
Alexey A. Lagunin
7,8,
Vladimir V. Poroikov
7,
Hasmik S. Harutyunyan
9,10,
Konstantin B. Yenkoyan
9,10,* and
Allan V. Kalueff
1,2,3,4,5,6,9,*
1
Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg 197341, Russia
2
Neurobiology Program, Sirius University of Science and Technology, Sirius Federal Territory 354340, Russia
3
Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg 199034, Russia
4
Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny 197758, Russia
5
Neuroscience Group, Moscow Institute of Physics and Technology, Moscow 115184, Russia
6
Vivarium, Ural Federal University, Yekaterinburg 620049, Russia
7
Department of Bioinformatics, Institute of Biomedical Chemistry, Moscow 119121, Russia
8
Department of Bioinformatics, Pirogov Russian National Research Medical University, Moscow 117997, Russia
9
Neuroscience Laboratory, COBRAIN Center, Yerevan State Medical University Named after M. Heratsi, Yerevan 0025, Armenia
10
Department of Biochemistry, Yerevan State Medical University Named after M. Heratsi, Yerevan 0025, Armenia
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(11), 9482; https://doi.org/10.3390/ijms24119482
Submission received: 16 April 2023 / Revised: 14 May 2023 / Accepted: 15 May 2023 / Published: 30 May 2023
(This article belongs to the Topic Applications of Biomedical Technology and Molecular Biological Approach in Brain Diseases)
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Abstract

Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance problems. Collectively, this calls for the development of novel drug targets for treating depressed and schizophrenic patients. Here, we discuss recent translational advances, research tools and approaches, aiming to facilitate innovative drug discovery in this field. Providing a comprehensive overview of current antidepressants and antipsychotic drugs, we also outline potential novel molecular targets for treating depression and schizophrenia. We also critically evaluate multiple translational challenges and summarize various open questions, in order to foster further integrative cross-discipline research into antidepressant and antipsychotic drug development.
Keywords: depression; psychosis; schizophrenia; pathogenesis; novel molecular targets depression; psychosis; schizophrenia; pathogenesis; novel molecular targets

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MDPI and ACS Style

Kositsyn, Y.M.; de Abreu, M.S.; Kolesnikova, T.O.; Lagunin, A.A.; Poroikov, V.V.; Harutyunyan, H.S.; Yenkoyan, K.B.; Kalueff, A.V. Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. Int. J. Mol. Sci. 2023, 24, 9482. https://doi.org/10.3390/ijms24119482

AMA Style

Kositsyn YM, de Abreu MS, Kolesnikova TO, Lagunin AA, Poroikov VV, Harutyunyan HS, Yenkoyan KB, Kalueff AV. Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. International Journal of Molecular Sciences. 2023; 24(11):9482. https://doi.org/10.3390/ijms24119482

Chicago/Turabian Style

Kositsyn, Yuriy M., Murilo S. de Abreu, Tatiana O. Kolesnikova, Alexey A. Lagunin, Vladimir V. Poroikov, Hasmik S. Harutyunyan, Konstantin B. Yenkoyan, and Allan V. Kalueff. 2023. "Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies" International Journal of Molecular Sciences 24, no. 11: 9482. https://doi.org/10.3390/ijms24119482

APA Style

Kositsyn, Y. M., de Abreu, M. S., Kolesnikova, T. O., Lagunin, A. A., Poroikov, V. V., Harutyunyan, H. S., Yenkoyan, K. B., & Kalueff, A. V. (2023). Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. International Journal of Molecular Sciences, 24(11), 9482. https://doi.org/10.3390/ijms24119482

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