Signet-Ring Cell Squamous Cell Carcinoma: A Biphenotypic Neoplasm of the Gastro-Esophageal Junction with Uncertain Biological Potential: Case Report and Literature Review
Abstract
:1. Introduction
2. Case Presentation
2.1. Personal History
2.2. Laboratory Examinations
2.3. Imaging and Endoscopic Examinations
2.4. Surgery
2.5. Gross and Histopathological Assessment of Surgical Specimens
2.6. Immunohistochemical and Molecular Profile of Tumor Cells
2.7. Outcome and Follow-Up
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Antibody | Clone | Manufacturer/ Country | Retrieval | Dilution | Classic SCC Component | Signet-Ring Cells |
---|---|---|---|---|---|---|
Cytokeratin | AE1/AE3 | ImmunoLogic/ Netherland | High pH | RTU | Positive | Positive |
Keratin 5/6 | D5/16B4 | Dako/Denmark | High pH | RTU | Positive | Positive |
p63 | 4A4 | ImmunoLogic | High pH | 1:100 | Positive | Positive |
p40 | ZR8 | BioSB/USA | High pH | 1:50 | Positive | Positive |
MLH1 | ES05 | Dako | High pH | RTU | Positive | Positive |
MSH2 | FE11 | Dako | High pH | RTU | Positive | Positive |
MSH6 | EP49 | Dako | High pH | RTU | Positive | Positive |
PMS2 | EP51 | Dako | High pH | RTU | Positive | Positive |
β-catenin | β-catenin1 | Dako | High pH | RTU | Membrane positivity | Nuclear positivity |
E-cadherin | NCH-38 | Dako | High pH | RTU | Positive | Focally loss |
N-cadherin | 6G11 | Dako | Citrate | 1:100 | Negative | Negative |
Vimentin | V9 | Dako | High pH | 1:800 | Negative | Positive |
Slug | H-140 | Santa Cruz/USA | High pH | 1:100 | Negative | Positive |
HER2 | Polyclonal | Dako | High pH | 1:800 | Negative | Negative |
PD-1 | NAT105 | A.Menarini/Italy | High pH | 1:50 | Negative | Negative |
PD-L1 | 22C3 | Dako | Citrate | 1:50 | Negative | Negative |
VEGF | VG-1 | Abcam/UK | High pH | 1:50 | Negative | Negative |
EGFR/HER1 | H11 | Dako | High pH | 1:100 | Positive | Positive |
Sox2 | Polyclonal | EMD Millipore/USA | Citrate | 1:6000 | Negative | Positive |
Oct3/4 | N1NK | Dako | High pH | 1:50 | Negative | Negative |
CD44 | DF1485 | Dako | Citrate | 1:50 | Positive | Positive |
CEA | II-7 | Dako | High pH | 1:50 | Negative | Negative |
CA125 | M11 | Dako | Citrate | 1:20 | Negative | Negative |
CA19-9 | CA19-9 | Leica/UK | Citrate | 1:200 | Negative | Negative |
CA72-4 | B72.3 | ThermoScientific/ UK | High pH | 1:200 | Negative | Negative |
EBV | CS.1-4 | Dako | Citrate | 1:100 | Negative | Negative |
p16 | Anti-p16 | Biotech/USA | High pH | 1:100 | Negative | Negative |
Case No. | Authors, Year of Publication | Patient’s Gender | Patient’s Age (Years) | Localization | Diameter (mm) |
---|---|---|---|---|---|
1. | Cramer and Heggeness (1988) [6] | Male | 69 | Skin (forehead) | NA |
2. | Kupryjanczyk et al. (1992) [9] | Female | 74 | Uterine cervix | NA |
3. | Female | 84 | Uterine cervix | NA | |
4. | McKinley et al. (1998) [7] | Male | 50 | Skin (neck) | 6 mm |
5. | Bastian et al. (1999) [15] | Female | 79 | Skin (right cheek) | NA |
6. | Bastian et al. (1999) [15] | Male | 82 | Skin (temple) | NA |
7. | Bastian et al. (1999) [15] | Male | 83 | Skin (ear) | NA |
8. | Bastian et al. (1999) [15] | Male | 80 | Skin (forehead) | NA |
9. | Bastian et al. (1999) [15] | Male | 87 | Skin (scalp) | NA |
10. | Bastian et al. (1999) [15] | - | - | - | - |
11. | Bastian et al. (1999) [15] | Male | 76 | Skin (forehead) | NA |
12. | Proia et al. (2006) [16] | Female | 93 | Skin (eyelid) | 17 mm |
13. | El Demellawy et al. (2011) [12] | Female | 84 | Upper Lip | 11 mm |
14. | Lortscher et al. (2012) [17] | Male | 67 | Skin (canthus/palpebral commissure) | 15 mm |
15. | Nakajima et al. (2013) [11] | Male | 83 | Skin (finger) | 31 mm |
16. | Park (2015) [13] | Male | 64 | Lung | 29 mm |
17. | Wang et al. (2016) [14] | Female | 78 | Skin (thigh) | 50 mm |
18. | Lee (2016) [10] | Female | 82 | Esophagus | 55 mm |
19. | Yigit et al. (2018) [8] | Male | 85 | Lung | 42 mm |
20. | Handra-Luca (2019) [18] | - | - | Lung | - |
21. | Findeis et al. (2020) [19] | Female Transgender | 66 | Skin (parotid region) | 56 mm |
22. | Haghayeghi et al. (2020) [20] | Male | 71 | Skin (ear) | 15 mm |
23. | Apandi et al. (2022) [24] | Male | 65 | Oral cavity (gingiva) | 10 mm |
24. | Present case | Male | 59 | Esophagus | 33 mm |
Signet-Ring SCC | Clear Cell SCC | Acantholytic/Adenoid/ Pseudo-Glandular SCC | |
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Histology |
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Special stains |
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IHC |
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Clinical behavior | High aggressivity | Moderate/high aggressivity | Moderate aggressivity |
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Satala, C.B.; Kovacs, Z.; Bara, T., Jr.; Jung, I.; Gurzu, S. Signet-Ring Cell Squamous Cell Carcinoma: A Biphenotypic Neoplasm of the Gastro-Esophageal Junction with Uncertain Biological Potential: Case Report and Literature Review. Int. J. Mol. Sci. 2023, 24, 9535. https://doi.org/10.3390/ijms24119535
Satala CB, Kovacs Z, Bara T Jr., Jung I, Gurzu S. Signet-Ring Cell Squamous Cell Carcinoma: A Biphenotypic Neoplasm of the Gastro-Esophageal Junction with Uncertain Biological Potential: Case Report and Literature Review. International Journal of Molecular Sciences. 2023; 24(11):9535. https://doi.org/10.3390/ijms24119535
Chicago/Turabian StyleSatala, Catalin Bogdan, Zsolt Kovacs, Tivadar Bara, Jr., Ioan Jung, and Simona Gurzu. 2023. "Signet-Ring Cell Squamous Cell Carcinoma: A Biphenotypic Neoplasm of the Gastro-Esophageal Junction with Uncertain Biological Potential: Case Report and Literature Review" International Journal of Molecular Sciences 24, no. 11: 9535. https://doi.org/10.3390/ijms24119535