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Volume 24
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Review

DNA Methylation in Alcohol Use Disorder

by
Qingmeng Zheng
1,
Heng Wang
1,
An Yan
1,
Fangyuan Yin
2 and
Xiaomeng Qiao
1,*
1
Department of Pathology and Forensic Medicine, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
2
School of Medicine, College of Forensic Science, Xi’an Jiaotong University, Xi’an 710061, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(12), 10130; https://doi.org/10.3390/ijms241210130
Submission received: 18 May 2023 / Revised: 10 June 2023 / Accepted: 13 June 2023 / Published: 14 June 2023
(This article belongs to the Section Molecular Neurobiology)
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Abstract

Excessive drinking damages the central nervous system of individuals and can even cause alcohol use disorder (AUD). AUD is regulated by both genetic and environmental factors. Genes determine susceptibility to alcohol, and the dysregulation of epigenome drives the abnormal transcription program and promotes the occurrence and development of AUD. DNA methylation is one of the earliest and most widely studied epigenetic mechanisms that can be inherited stably. In ontogeny, DNA methylation pattern is a dynamic process, showing differences and characteristics at different stages. DNA dysmethylation is prevalent in human cancer and alcohol-related psychiatric disorders, resulting in local hypermethylation and transcriptional silencing of related genes. Here, we summarize recent findings on the roles and regulatory mechanisms of DNA methylation, the development of methyltransferase inhibitors, methylation alteration during alcohol exposure at different stages of life, and possible therapeutic options for targeting methylation in human and animal studies.
Keywords: alcohol; DNA methylation; gene transcription; age; inhibitors alcohol; DNA methylation; gene transcription; age; inhibitors

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MDPI and ACS Style

Zheng, Q.; Wang, H.; Yan, A.; Yin, F.; Qiao, X. DNA Methylation in Alcohol Use Disorder. Int. J. Mol. Sci. 2023, 24, 10130. https://doi.org/10.3390/ijms241210130

AMA Style

Zheng Q, Wang H, Yan A, Yin F, Qiao X. DNA Methylation in Alcohol Use Disorder. International Journal of Molecular Sciences. 2023; 24(12):10130. https://doi.org/10.3390/ijms241210130

Chicago/Turabian Style

Zheng, Qingmeng, Heng Wang, An Yan, Fangyuan Yin, and Xiaomeng Qiao. 2023. "DNA Methylation in Alcohol Use Disorder" International Journal of Molecular Sciences 24, no. 12: 10130. https://doi.org/10.3390/ijms241210130

APA Style

Zheng, Q., Wang, H., Yan, A., Yin, F., & Qiao, X. (2023). DNA Methylation in Alcohol Use Disorder. International Journal of Molecular Sciences, 24(12), 10130. https://doi.org/10.3390/ijms241210130

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