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Article

Plasma Lipidomics Analysis Reveals the Potential Role of Lysophosphatidylcholines in Abdominal Aortic Aneurysm Progression and Formation

by
Ting Xie
1,
Chuxiang Lei
2,
Wei Song
3,
Xunyao Wu
1,
Jianqiang Wu
3,
Fangyuan Li
1,
Yanze Lv
2,
Yuexin Chen
2,
Bao Liu
2 and
Yuehong Zheng
2,*
1
Clinical Biobank, Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
2
Department of Vascular Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
3
Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(12), 10253; https://doi.org/10.3390/ijms241210253
Submission received: 14 May 2023 / Revised: 13 June 2023 / Accepted: 14 June 2023 / Published: 16 June 2023
(This article belongs to the Collection 21st Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism)
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Abstract

Abdominal aortic aneurysm (AAA) is hallmarked by irreversible dilation of the infrarenal aorta. Lipid deposition in the aortic wall and the potential importance of a lipid disorder in AAA etiology highlight the need to explore lipid variation during AAA development. This study aimed to systematically characterize the lipidomics associated with AAA size and progression. Plasma lipids from 106 subjects (36 non-AAA controls and 70 AAA patients) were comprehensively analyzed using untargeted lipidomics. An AAA animal model was established by embedding angiotensin-II pump in ApoE-/- mice for four weeks and blood was collected at 0, 2 and 4 weeks for lipidomic analysis. Using a false-discovery rate (FDR) < 0.05, a group of lysophosphatidylcholines (lysoPCs) were specifically decreased in AAA patients and mice. LysoPCs were principally lower in the AAA patients with larger diameter (diameter > 50 mm) than those with a smaller size (30 mm < diameter < 50 mm), and levels of lysoPCs were also found to be decreased with modelling time and aneurysm formation in AAA mice. Correlation matrices between lipids and clinical characteristics identified that the positive correlation between lysoPCs and HDL-c was reduced and negative correlations between lysoPCs and CAD rate, lysoPCs and hsCRP were converted to positive correlations in AAA compared to control. Weakened positive correlations between plasma lysoPCs and circulating HDL-c in AAA suggested that HDL-lysoPCs may elicit instinctive physiological effects in AAA. This study provides evidence that reduced lysoPCs essentially underlie the pathogenesis of AAA and that lysoPCs are promising biomarkers for AAA development.
Keywords: lysoPC; abdominal aortic aneurysm; lipid metabolism; lipidomics; HDL-c lysoPC; abdominal aortic aneurysm; lipid metabolism; lipidomics; HDL-c

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MDPI and ACS Style

Xie, T.; Lei, C.; Song, W.; Wu, X.; Wu, J.; Li, F.; Lv, Y.; Chen, Y.; Liu, B.; Zheng, Y. Plasma Lipidomics Analysis Reveals the Potential Role of Lysophosphatidylcholines in Abdominal Aortic Aneurysm Progression and Formation. Int. J. Mol. Sci. 2023, 24, 10253. https://doi.org/10.3390/ijms241210253

AMA Style

Xie T, Lei C, Song W, Wu X, Wu J, Li F, Lv Y, Chen Y, Liu B, Zheng Y. Plasma Lipidomics Analysis Reveals the Potential Role of Lysophosphatidylcholines in Abdominal Aortic Aneurysm Progression and Formation. International Journal of Molecular Sciences. 2023; 24(12):10253. https://doi.org/10.3390/ijms241210253

Chicago/Turabian Style

Xie, Ting, Chuxiang Lei, Wei Song, Xunyao Wu, Jianqiang Wu, Fangyuan Li, Yanze Lv, Yuexin Chen, Bao Liu, and Yuehong Zheng. 2023. "Plasma Lipidomics Analysis Reveals the Potential Role of Lysophosphatidylcholines in Abdominal Aortic Aneurysm Progression and Formation" International Journal of Molecular Sciences 24, no. 12: 10253. https://doi.org/10.3390/ijms241210253

APA Style

Xie, T., Lei, C., Song, W., Wu, X., Wu, J., Li, F., Lv, Y., Chen, Y., Liu, B., & Zheng, Y. (2023). Plasma Lipidomics Analysis Reveals the Potential Role of Lysophosphatidylcholines in Abdominal Aortic Aneurysm Progression and Formation. International Journal of Molecular Sciences, 24(12), 10253. https://doi.org/10.3390/ijms241210253

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