Cyclic AMP but Not Calmodulin as a Potential Wasoconstrictor in Simulated Reperfusion
Abstract
:1. Introduction
2. Results
2.1. Arterial Incubation in the Presence of Forskolin
2.2. Arterial Incubation in the Presence of A7
3. Discussion
4. Materials and Methods
4.1. Artery Preparation
4.2. Study Design
4.3. Compounds Used in the Extravascular Space
4.4. Research Phases
4.5. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Test Conditions | |||||
---|---|---|---|---|---|---|
Control | 60 min Ischemia | Reperfusion | ||||
Forskolin | A7 | Forskolin | A7 | Forskolin | A7 | |
n 1 | 24 | 22 | 29 | 23 | 25 | 27 |
P0 [mmHg] 2 | 1.58 | 3.16 | 0.83 | 2.80 | 3.83 | 2.33 |
Pend [mmHg] 3 | 66.76 | 78.16 | 40.05 * | 70.73 | 107.86 **/a | 89.26 ** |
Erel [%] 4 | 72 | 84 | 43 * | 76 * | 116 **/a | 96 ** |
EC50 [M/L] 5 | * | **/a | a | |||
Rp 6 | 0.11 | 0.77 | 0.73 | 1.33 | 1.20 | 0.70 |
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Ohla, J.; Wiciński, M.; Słupski, M.; Zabrzyński, J.; Malinowski, B. Cyclic AMP but Not Calmodulin as a Potential Wasoconstrictor in Simulated Reperfusion. Int. J. Mol. Sci. 2023, 24, 10355. https://doi.org/10.3390/ijms241210355
Ohla J, Wiciński M, Słupski M, Zabrzyński J, Malinowski B. Cyclic AMP but Not Calmodulin as a Potential Wasoconstrictor in Simulated Reperfusion. International Journal of Molecular Sciences. 2023; 24(12):10355. https://doi.org/10.3390/ijms241210355
Chicago/Turabian StyleOhla, Jakub, Michał Wiciński, Maciej Słupski, Jan Zabrzyński, and Bartosz Malinowski. 2023. "Cyclic AMP but Not Calmodulin as a Potential Wasoconstrictor in Simulated Reperfusion" International Journal of Molecular Sciences 24, no. 12: 10355. https://doi.org/10.3390/ijms241210355