Next Article in Journal
Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[d]imidazole-Based Cannabinoid Type 2 (CB2) Receptor Agonists
Previous Article in Journal
Mesenchymal Stem Cells and Exosomes: A Novel Therapeutic Approach for Corneal Diseases
Previous Article in Special Issue
Multifaceted Benefits of GDF11 Treatment in Spinal Cord Injury: In Vitro and In Vivo Studies
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 24
Issue 13
10.3390/ijms241310902
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Cerebrospinal Fluid Biomarkers for Diagnosis and the Prognostication of Acute Ischemic Stroke: A Systematic Review

by
Anant Naik
1,
Olufunmilola Adeleye
2,
Stefan W. Koester
3,
Ethan A. Winkler
3,
Joelle N. Hartke
3,
Katherine Karahalios
3,
Sandra Mihaljevic
3,
Anupama Rani
3,
Sudhanshu Raikwar
3,
Jarrod D. Rulney
3,
Shashvat M. Desai
3,
Lea Scherschinski
3,
Andrew F. Ducruet
3,
Felipe C. Albuquerque
3,
Michael T. Lawton
3,
Joshua S. Catapano
3,
Ashutosh P. Jadhav
3,† and
Ruchira M. Jha
3,*,†
1
Carle Illinois College of Medicine, University of Illinois Urbana-Champaign, Champaign, IL 61820, USA
2
Mayo Clinic Alix School of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
3
Department of Neurosurgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ 85013, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2023, 24(13), 10902; https://doi.org/10.3390/ijms241310902
Submission received: 10 February 2023 / Revised: 19 June 2023 / Accepted: 21 June 2023 / Published: 30 June 2023
(This article belongs to the Special Issue Pharmacological Strategies for Neuroinflammation in Brain Injury)
Browse Figures
Versions Notes

Abstract

Despite the high incidence and burden of stroke, biological biomarkers are not used routinely in clinical practice to diagnose, determine progression, or prognosticate outcomes of acute ischemic stroke (AIS). Because of its direct interface with neural tissue, cerebrospinal fluid (CSF) is a potentially valuable source for biomarker development. This systematic review was conducted using three databases. All trials investigating clinical and preclinical models for CSF biomarkers for AIS diagnosis, prognostication, and severity grading were included, yielding 22 human trials and five animal studies for analysis. In total, 21 biomarkers and other multiomic proteomic markers were identified. S100B, inflammatory markers (including tumor necrosis factor-alpha and interleukin 6), and free fatty acids were the most frequently studied biomarkers. The review showed that CSF is an effective medium for biomarker acquisition for AIS. Although CSF is not routinely clinically obtained, a potential benefit of CSF studies is identifying valuable biomarkers from the pathophysiologic microenvironment that ultimately inform optimization of targeted low-abundance assays from peripheral biofluid samples (e.g., plasma). Several important catabolic and anabolic markers can serve as effective measures of diagnosis, etiology identification, prognostication, and severity grading. Trials with large cohorts studying the efficacy of biomarkers in altering clinical management are still needed.
Keywords: biomarkers; cerebrospinal fluid; genomics; inflammatory markers; ischemic stroke biomarkers; cerebrospinal fluid; genomics; inflammatory markers; ischemic stroke

Share and Cite

MDPI and ACS Style

Naik, A.; Adeleye, O.; Koester, S.W.; Winkler, E.A.; Hartke, J.N.; Karahalios, K.; Mihaljevic, S.; Rani, A.; Raikwar, S.; Rulney, J.D.; et al. Cerebrospinal Fluid Biomarkers for Diagnosis and the Prognostication of Acute Ischemic Stroke: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 10902. https://doi.org/10.3390/ijms241310902

AMA Style

Naik A, Adeleye O, Koester SW, Winkler EA, Hartke JN, Karahalios K, Mihaljevic S, Rani A, Raikwar S, Rulney JD, et al. Cerebrospinal Fluid Biomarkers for Diagnosis and the Prognostication of Acute Ischemic Stroke: A Systematic Review. International Journal of Molecular Sciences. 2023; 24(13):10902. https://doi.org/10.3390/ijms241310902

Chicago/Turabian Style

Naik, Anant, Olufunmilola Adeleye, Stefan W. Koester, Ethan A. Winkler, Joelle N. Hartke, Katherine Karahalios, Sandra Mihaljevic, Anupama Rani, Sudhanshu Raikwar, Jarrod D. Rulney, and et al. 2023. "Cerebrospinal Fluid Biomarkers for Diagnosis and the Prognostication of Acute Ischemic Stroke: A Systematic Review" International Journal of Molecular Sciences 24, no. 13: 10902. https://doi.org/10.3390/ijms241310902

APA Style

Naik, A., Adeleye, O., Koester, S. W., Winkler, E. A., Hartke, J. N., Karahalios, K., Mihaljevic, S., Rani, A., Raikwar, S., Rulney, J. D., Desai, S. M., Scherschinski, L., Ducruet, A. F., Albuquerque, F. C., Lawton, M. T., Catapano, J. S., Jadhav, A. P., & Jha, R. M. (2023). Cerebrospinal Fluid Biomarkers for Diagnosis and the Prognostication of Acute Ischemic Stroke: A Systematic Review. International Journal of Molecular Sciences, 24(13), 10902. https://doi.org/10.3390/ijms241310902

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop