DHEA Induces Sex-Associated Differential Patterns in Cytokine and Antibody Levels in Mice Infected with Plasmodium berghei ANKA
Abstract
:1. Introduction
2. Results
2.1. DHEA Administration Dramatically Increased DHEA Levels in Mice Infected with P. berghei ANKA
2.2. Effects of Modifying DHEA Concentration on Temperature and Hemoglobin Concentration in Mice Infected with P. berghei ANKA
2.3. DHEA Administration to Intact Male Mice Increased Parasitemia
2.4. Reducing the DHEA Concentration Generated a Dimorphic Pattern in the CD3+, CD19+ and NK Cell Populations of Uninfected Mice
2.5. DHEA Generated a Dimorphic Pattern in the Concentrations of IFN-γ, IL-2 and IL-4
2.6. Reconstitution of Gx Males with DHEA Increased the Concentration of the IgG Subclass
3. Discussion
4. Materials and Methods
4.1. Mice
4.2. Gonadectomy
4.2.1. Orchidectomy
4.2.2. Ovariectomy
4.3. DHEA Administration
4.4. Parasite, Infection and Parasitemia
4.5. Body Weight and Temperature
4.6. Hemoglobin Concentration
4.7. Extraction of Sex Hormones from Plasma Samples
4.8. Quantification of DHEA in Plasma
4.9. Quantification of Cell Populations in the Spleen
4.10. Plasma Th1/Th2/Th17 Cytokine Quantification
4.11. Quantification of IgM and IgG Antibody Concentrations
4.12. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Buendía-González, F.O.; Cervantes-Candelas, L.A.; Aguilar-Castro, J.; Fernández-Rivera, O.; Nolasco-Pérez, T.d.J.; López-Padilla, M.S.; Chavira-Ramírez, D.R.; Cervantes-Sandoval, A.; Legorreta-Herrera, M. DHEA Induces Sex-Associated Differential Patterns in Cytokine and Antibody Levels in Mice Infected with Plasmodium berghei ANKA. Int. J. Mol. Sci. 2023, 24, 12549. https://doi.org/10.3390/ijms241612549
Buendía-González FO, Cervantes-Candelas LA, Aguilar-Castro J, Fernández-Rivera O, Nolasco-Pérez TdJ, López-Padilla MS, Chavira-Ramírez DR, Cervantes-Sandoval A, Legorreta-Herrera M. DHEA Induces Sex-Associated Differential Patterns in Cytokine and Antibody Levels in Mice Infected with Plasmodium berghei ANKA. International Journal of Molecular Sciences. 2023; 24(16):12549. https://doi.org/10.3390/ijms241612549
Chicago/Turabian StyleBuendía-González, Fidel Orlando, Luis Antonio Cervantes-Candelas, Jesús Aguilar-Castro, Omar Fernández-Rivera, Teresita de Jesús Nolasco-Pérez, Monserrat Sofía López-Padilla, David Roberto Chavira-Ramírez, Armando Cervantes-Sandoval, and Martha Legorreta-Herrera. 2023. "DHEA Induces Sex-Associated Differential Patterns in Cytokine and Antibody Levels in Mice Infected with Plasmodium berghei ANKA" International Journal of Molecular Sciences 24, no. 16: 12549. https://doi.org/10.3390/ijms241612549