Ethanol Kinetics in the Human Brain Determined by Magnetic Resonance Spectroscopy
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Experimental Set-Up
4.2. Chemicals and Instrumentation
4.2.1. Determination of the Blood Ethanol Concentration
4.2.2. MRS Measurements
4.2.3. Postprocessing and Quantification
4.2.4. Comparison of Plasma Ethanol and Brain Ethanol Concentrations
4.3. Statistical Evaluation
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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V-Nr. | Amount of Wodka (40 vol-%) [mL] | Drinking Time [min] | Plasma Ethanol Concentration at the End of Drinking [g/L] | Interval between End of Drinking and First MRS Measurement [min] | Interval between Beginning of Drinking and First MRS Measurement [min] | Highest Measured Plasma Ethanol Concentration [g/L] | Highest Measured Brain Ethanol Concentration [mM] | Ascending Part of the Curve Observable |
---|---|---|---|---|---|---|---|---|
1 | 155 | 14 | 0.16 | 20 | 34 | 0.66 | 11.2 | Shortly |
2 | 200 | 16 | 0.63 | 21 | 37 | 0.92 | 13.6 | No |
3 | 95 | 13 | 0.28 | 26 | 39 | 0.43 | 7.1 | No |
4 | 153 | 12 | 0.29 | 33 | 45 | 0.83 | 14.1 | No |
5 | 116 | 37 | 0.72 | 25 | 62 | 0.72 | 10.4 | No |
6 | 137 | 29 | 0.14 | 27 | 56 | 0.59 | 9.9 | Yes |
7 | 135 | 26 | 0.95 | 19 | 45 | 0.95 | 12.0 | (Not available) |
8 | 95 | 15 | 0.13 | 19 | 34 | 0.5 | 7.9 | Yes |
9 | 100 | 17 | 0.45 | 14 | 31 | 0.75 | 11.3 | No |
10 | 160 | 6 | 0.04 | 15 | 21 | 0.74 | 12.2 | Yes |
Pearson’s Corr. Coeff. | Slope | Intercept | |
---|---|---|---|
V01 | 0.9909 | 0.9028 | −3.6794 |
V02 | 0.9989 | 0.7264 | −1.8130 |
V03 | 0.9969 | 0.5688 | −0.1000 |
V04 | 0.9884 | 0.6953 | −2.5368 |
V05 | 0.9982 | 0.7434 | −2.3142 |
V06 | 0.9737 | 0.9330 | −2.2611 |
V07 | 0.9862 | 0.5600 | 0.7960 |
V08 | 0.9997 | 0.8402 | −1.5809 |
V09 | 0.9987 | 0.7452 | −1.6414 |
V10 | 0.4773 | 0.4880 | 1.7454 |
0.9409 ± 0.1631 | 0.7203 ± 0.1481 | −1.3385 ± 1.6565 |
V-Nr. | Sex | Age [a] | Body Weight [kg] | Body Height [cm] | BMI | Ethanol Uptake per Week (Average) | Known Illnesses | Regular Medication |
---|---|---|---|---|---|---|---|---|
1 | M | 35 | 80 | 178 | 25.2 | 0.5 l red wine | None | None |
2 | M | 61 | 112 | 194 | 29.8 | 0.25 l beer | Hemithyreoidektomie | None |
3 | F | 29 | 58 | 168 | 20.5 | 0.1 l wine | None | None |
4 | M | 33 | 80 | 186 | 23.1 | 1 l beer | Coeliac disease | None (gluten-free diet) |
5 | F | 28 | 65 | 165 | 23.9 | 0.5 l wine | None | None |
6 | M | 67 | 72 | 176 | 23.2 | 1 l wine | Arterial hypertension | Ramipril |
7 | F | 60 | 90 | 154 | 37.9 | Very low | Arterial hypertension | Ramipril, hydrochlorothiazide, amlodipine |
8 | F | 29 | 57 | 160 | 22.3 | 0.25 l wine | None | None |
9 | F | 63 | 60 | 168 | 21.3 | 0.25 l wine | Arterial hypertension | Spironolactone, cholecalciferol |
10 | M | 61 | 84 | 187 | 24 | Very low | Tinnitus | Testosterone |
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Thierauf-Emberger, A.; Schuldis, D.; Dacko, M.; Lange, T. Ethanol Kinetics in the Human Brain Determined by Magnetic Resonance Spectroscopy. Int. J. Mol. Sci. 2023, 24, 13499. https://doi.org/10.3390/ijms241713499
Thierauf-Emberger A, Schuldis D, Dacko M, Lange T. Ethanol Kinetics in the Human Brain Determined by Magnetic Resonance Spectroscopy. International Journal of Molecular Sciences. 2023; 24(17):13499. https://doi.org/10.3390/ijms241713499
Chicago/Turabian StyleThierauf-Emberger, Annette, Dominik Schuldis, Michael Dacko, and Thomas Lange. 2023. "Ethanol Kinetics in the Human Brain Determined by Magnetic Resonance Spectroscopy" International Journal of Molecular Sciences 24, no. 17: 13499. https://doi.org/10.3390/ijms241713499