Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus
Abstract
:1. Introduction
2. Results
2.1. Characteristics of the Recruited Patients and Healthy Controls
2.2. Metrnβ Expressions and Their Association with SLE Disease Activity
2.3. Association between Metrnβ and SLE Related Clinical Parameters
2.4. Possible Regulations of Metrnβ on Immunological Tolerance during SLE Pathogenesis
2.5. Association of Metrnβ with Distinct Inflammatory Patterns in SLE
2.6. Potential Value of Metrnβ as a Biomarker in the Diagnosis of SLE
3. Discussion
4. Materials and Methods
4.1. Study Design and Ethics
4.2. Quantification of Serum Metrnβ Levels
4.3. Longitudinal Cytokine/Chemokine Profile
4.4. Flow Cytometry Analysis of Immune Cells
4.5. Measurement of Laboratory Parameters
4.6. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | AUC (95% CI) | Cutoff Value | Sensitivity % | Specificity % | Youden Index % |
---|---|---|---|---|---|
Anti-dsDNA Ab, IU/mL | 0.8040 (0.7001–0.9078) | 8.920 | 74.47 | 85.71 | 60.18 |
ESR, mm/h | 0.6661 (0.5462–0.7860) | 27.50 | 44.74 | 90.57 | 35.31 |
CRP, mg/L | 0.8134 (0.7306–0.8962) | 1.3 | 66.67 | 88.68 | 55.35 |
LDH, U/L | 0.7215 (0.6032–0.8398) | 161 | 100 | 35.85 | 35.85 |
IgG, g/L | 0.5734 (0.4489–0.6979) | 12.15 | 43.9 | 83.02 | 26.92 |
Metrnβ, pg/mL | 0.8250 (0.7379–0.9121) | 1131 | 67.35 | 96.15 | 63.50 |
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Zhang, C.; Cai, S.; Li, Y.; Xu, X.; Liu, Y.; Qiao, H.; Wong, C.-K.; Wu, G.; Jin, H.; Gao, X. Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus. Int. J. Mol. Sci. 2023, 24, 13607. https://doi.org/10.3390/ijms241713607
Zhang C, Cai S, Li Y, Xu X, Liu Y, Qiao H, Wong C-K, Wu G, Jin H, Gao X. Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus. International Journal of Molecular Sciences. 2023; 24(17):13607. https://doi.org/10.3390/ijms241713607
Chicago/Turabian StyleZhang, Chen, Shijie Cai, Ying Li, Xiaoyan Xu, Yonghui Liu, Huaiyu Qiao, Chun-Kwok Wong, Guoqiu Wu, Hui Jin, and Xun Gao. 2023. "Elevation of Metrnβ and Its Association with Disease Activity in Systemic Lupus Erythematosus" International Journal of Molecular Sciences 24, no. 17: 13607. https://doi.org/10.3390/ijms241713607