Roles of Stress Response in Autophagy Processes and Aging-Related Diseases
Abstract
:1. Introduction
2. Autophagy Processes
3. Role of Stress Response Pathway in Macroautophagy
4. Role of Molecular Chaperones in CMA and Microautophagy
5. Proteostasis and Longevity
Targets | Functions | Effects on Lifespan Extension | Ref. |
---|---|---|---|
C. elegans | |||
HSF1 | Transcription factor | hsf1 RNAi: lifespan extension (−37%) hsf1 overexpression: lifespan extension (+40%) | [86] |
EP300 | Macroautophagy | Acetyltransferase EP300 inhibitor (macroautophagy activation) lifespan extension (+15%) | [121] |
Rubicon | Macroautophagy | rub-1 knockdown (macroautophagy activation) lifespan extension (+21%) | [120] |
Drosophila | |||
HSP70 | Chaperone | Heat treatment (20–30 min): lifespan extension (+30%) | [84] |
HSP22 | Chaperone | Long-lived drosophila lines: hsp22 RNA level (2–10 fold increase) | [85] |
Atg1 | Macroautophagy | Neuronal overexpression lifespan extension (+25%) | [117] |
Atg8 | Macroautophagy | Neuronal overexpression lifespan extension (+56%) | [115] |
AMPK | Macroautophagy | Neuronal overexpression lifespan extension (+113%) | [117] |
EP300 | Macroautophagy | Acetyltransferase EP300 inhibitor (macroautophagy activation) lifespan extension (+30%) | [121] |
Rubicon | Macroautophagy | dRubicon knockdown (macroautophagy activation) lifespan extension (+20%) | [120] |
Mice | |||
Atg5 | Macroautophagy | Overexpression lifespan extension (+17.2%) | [116] |
mTORC1 | Kinase | mTORC1 inhibitor rapamycin (macroautophagy activation) Oral administrationheterogeneous mice: lifespan extension (males: +9%; females: +14%) C57BL/6J.Nia: lifespan extension (males: +11%; females: +16%) Intraperitoneal administrationC57BL/6J.Nia: lifespan extension (+14%) CD1: (males: +8.9%; females: +8.4%) | [109] |
AMPK | Kinase | AMPK activator metformin (macroautophagy activation) Oral administration 0.1% in diet lifespan extension (C57BL/6 males: +5.8%; B6C3F1 males: +4.2%) 1% in diet: lifespan extension (C57BL/6 males: −14.4) | [111] |
Beclin 1 | Macroautophagy | Becn1F121A/F121A knock-in mice (macroautophagy activation) lifespan extension (males: +12%; females: +11%) | [119] |
6. Stress Response and Autophagy Processes as Therapeutic Targets of Neurodegenerative Diseases and Cancer
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Watanabe, Y.; Taguchi, K.; Tanaka, M. Roles of Stress Response in Autophagy Processes and Aging-Related Diseases. Int. J. Mol. Sci. 2023, 24, 13804. https://doi.org/10.3390/ijms241813804
Watanabe Y, Taguchi K, Tanaka M. Roles of Stress Response in Autophagy Processes and Aging-Related Diseases. International Journal of Molecular Sciences. 2023; 24(18):13804. https://doi.org/10.3390/ijms241813804
Chicago/Turabian StyleWatanabe, Yoshihisa, Katsutoshi Taguchi, and Masaki Tanaka. 2023. "Roles of Stress Response in Autophagy Processes and Aging-Related Diseases" International Journal of Molecular Sciences 24, no. 18: 13804. https://doi.org/10.3390/ijms241813804