Pharmacological Modulation of Oxidative Stress
Introduction
Author Contributions
Conflicts of Interest
References
- Sena, L.A.; Chandel, N.S. Physiological Roles of Mitochondrial Reactive Oxygen Species. Mol. Cell 2012, 48, 158–167. [Google Scholar] [CrossRef] [PubMed]
- Caliri, A.W.; Tommasi, S.; Besaratinia, A. Relationships Among Smoking, Oxidative Stress, Inflammation, Macromolecular Damage, and Cancer. Mutat. Res. Rev. Mutat. Res. 2021, 787, 108365. [Google Scholar] [CrossRef] [PubMed]
- Liguori, I.; Russo, G.; Curcio, F.; Bulli, G.; Aran, L.; Della-Morte, D.; Gargiulo, G.; Testa, G.; Cacciatore, F.; Bonaduce, D.; et al. Oxidative stress, Aging, and Diseases. Clin. Interv. Aging 2018, 13, 757–772. [Google Scholar] [CrossRef] [PubMed]
- Wang, D.K.; Zheng, H.L.; Zhou, W.S.; Duan, Z.W.; Jiang, S.D.; Li, B.; Zheng, X.F.; Jiang, L.S. Mitochondrial Dysfunction in Oxidative Stress-Mediated Intervertebral Disc Degeneration. Orthop. Surg. 2022, 14, 1569–1582. [Google Scholar] [CrossRef] [PubMed]
- Stepanić, V.; Čipak Gašparović, A.; Gall Trošelj, K.; Amić, D.; Žarković, N. Selected Attributes of Polyphenols in Targeting Oxidative Stress in Cancer. Curr. Top. Med. Chem. 2015, 15, 496–509. [Google Scholar] [CrossRef] [PubMed]
- Jaramillo, M.C.; Zhang, D.D. The emerging role of the Nrf2–Keap1 signaling pathway in cancer. Genes Dev. 2013, 27, 2179–2191. [Google Scholar] [CrossRef] [PubMed]
- Saha, S.; Buttari, B.; Panieri, E.; Profumo, E.; Saso, L. An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. Molecules 2020, 25, 5474. [Google Scholar] [CrossRef] [PubMed]
- Kansanen, E.; Kuosmanen, S.M.; Leinonen, H.; Levonen, A. The Keap1-Nrf2pathway: Mechanisms of Activation and Dysregulation in Cancer. Redox Biol. 2013, 1, 45–49. [Google Scholar] [CrossRef] [PubMed]
- Venci, J.V.; Gandhi, M.A. Dimethyl Fumarate (Tecfidera): A New Oral Agent for Multiple Sclerosis. Ann. Pharmacother. 2013, 47, 1697–1702. [Google Scholar] [CrossRef] [PubMed]
- Thiruvengadam, M.; Venkidasamy, B.; Subramanian, U.; Samynathan, R.; Ali Shariati, M.; Rebezov, M.; Girish, S.; Thangavel, S.; Dhanapal, A.R.; Fedoseeva, N.; et al. Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation. Antioxidants 2021, 10, 1859. [Google Scholar] [CrossRef] [PubMed]
- Tucci, P.; Lattanzi, R.; Severini, C.; Saso, L. Nrf2 Pathway in Huntington’s Disease (HD): What Is Its Role? Int. J. Mol. Sci. 2022, 23, 15272. [Google Scholar] [CrossRef] [PubMed]
- Simpson, D.S.A.; Oliver, P.L. ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease. Antioxidants 2020, 9, 743. [Google Scholar] [CrossRef] [PubMed]
- Malard, E.; Valable, S.; Bernaudin, M.; Pérès, E.; Chatre, L. The Reactive Species Interactome in the Brain. Antioxid. Red. Sig. 2021, 35, 1176–1206. [Google Scholar] [CrossRef] [PubMed]
- Stack, C.; Ho, D.; Wille, E.; Calingasan, N.Y.; Williams, C.; Liby, K.; Sporn, M.; Dumont, M.; Beal, M.F. Triterpenoids CDDO-Ethyl Amide and CDDO-Trifluoroethyl Amide Improve the Behavioral Phenotype and Brain Pathology in a Transgenic Mouse Model of Huntington’s Disease. Free Radic. Biol. Med. 2010, 49, 147–158. [Google Scholar] [CrossRef] [PubMed]
- Oliveira, A.M. Protective Effects of 3-Alkyl Luteolin Derivatives Are Mediated by Nrf2 Transcriptional Activity and Decreased Oxidative Stress in Huntington’s Disease Mouse Striatal Cells. Neurochem. Int. 2015, 91, 1–12. [Google Scholar] [CrossRef] [PubMed]
- Gonchar, O.O.; Maznychenko, A.V.; Klyuchko, O.M.; Mankovska, I.M.; Butowska, K.; Borowik, A.; Piosik, J.; Sokolowska, I. C60 Fullerene Reduces 3-Nitropropionic Acid-Induced Oxidative Stress Disorders and Mitochondrial Dysfunction in Rats by Modulation of P53, Bcl-2 and Nrf2 Targeted Proteins. Int. J. Mol. Sci. 2021, 22, 5444. [Google Scholar] [CrossRef] [PubMed]
- Ibrahim, W.W.; Abdel Rasheed, N.O. Diapocynin Neuroprotective Effects in 3-Nitropropionic Acid Huntington’s Disease Model in Rats: Emphasis on Sirt1/Nrf2 Signaling Pathway. Inflammopharmacology 2022, 30, 1745–1758. [Google Scholar] [CrossRef] [PubMed]
- Jalili, C.; Akhshi, N.; Rashidi, I.; Ghanbari, A. Harmine Protects Mercuric Chloride Kidney-Induced Injury by Antioxidant Activity in Male Mice: A Biochemical and Histological Study. Res. Pharm. Sci. 2020, 15, 541–550. [Google Scholar] [PubMed]
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Saha, S.; Saso, L. Pharmacological Modulation of Oxidative Stress. Int. J. Mol. Sci. 2023, 24, 14455. https://doi.org/10.3390/ijms241914455
Saha S, Saso L. Pharmacological Modulation of Oxidative Stress. International Journal of Molecular Sciences. 2023; 24(19):14455. https://doi.org/10.3390/ijms241914455
Chicago/Turabian StyleSaha, Sarmistha, and Luciano Saso. 2023. "Pharmacological Modulation of Oxidative Stress" International Journal of Molecular Sciences 24, no. 19: 14455. https://doi.org/10.3390/ijms241914455