Role of Biomaterials in the Development of Epithelial Support in 3D In Vitro Airway Epithelium Development: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Criteria
2.2. Data Extraction and Analysis
3. Results
3.1. Study Characteristics
3.2. Physicochemical, Mechanical, and Biological Properties
Type of Biomaterials/Scaffolds | Type of Cells | Outcomes | Conclusion |
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Microgrooved gelatin hydrogel crosslinked with glutaraldehyde [25] | Human bronchial epithelial cell line (BEAS-2B) | 1. Topographical
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Non-woven bilayered biodegradable chitosan-gelatin-polylactide (CGP) with hyaluronic acid (HA) immobilization scaffold [22] | Human respiratory epithelium cells (HRECs) | 1. Physicochemical properties
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Three-dimensionally printed porous structure of a thermoresponsive injectable polyethercarbonate (3D-TIPS) stiffness-softening elastomer nanohybrid impregnated with collagen nanofibrous hydrogel [26] |
| 1. Mechanical properties
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|
Electrospun nanofibers of poly(ε-caprolactone)/ depolymerized chitosan (PCL/chitosan) [27] | Porcine tracheobronchial epithelial (PTBE) cells | 1. Mechanical properties
|
|
| Respiratory epithelial cells (RECs) | 1. Contact angle
|
|
Three-dimensional-printing of silk fibroin/hydroxypropyl methylcellulose (SF/HPMC) thixotropic hydrogel [20] | Normal human bronchial epithelial cell line (BEAS-2B) | 1. Ultrastructure
|
|
Electrospun polyethylene terephthalate scaffold (PET) [18] | The epithelial cell line (Calu-3) The fibroblast (MRC-5) cell lines | 1. Trans-epithelial electrical resistance (TEER) measurements
|
|
Novel electrospun biphasic scaffold [21] | MRC5 and CALU3 cell lines | 1. Diameter
|
|
Collagen IV- and laminin-containing extracellular matrix [28] | Human bronchial epithelial cells (HBECs) | 1. Cell attachment, differentiation, and proliferation
| Collagen IV and laminin, two extracellular matrix proteins, are crucial for respiratory epithelial adhesion and growth in vitro. |
Fibrin gel [29] | Respiratory epithelial cells | 1. Cell differentiation
|
|
Porous three-dimensional silk fibroin scaffolds (3D SF) [30] | Human tracheobronchial epithelial cells (HBECs) | 1. Cell viability and proliferation:
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| Calu-3 bronchial epithelial cell line | 1. Biocompatibility:
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Microfluidic lung airway-on-a-chip with arrayable suspended gels [32] |
| 1. Cell adhesion:
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Human plasma [33] |
| 1. Histological analysis:
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Urinary bladder-derived ECM hydrogels [34] | Human bronchial epithelial cells (HBECs) | 1. Cell Proliferation and differentiation
|
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| 1. Cell differentiation and proliferation
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4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Nashihah, A.K.; Muhammad Firdaus, F.I.; Fauzi, M.B.; Mobarak, N.N.; Lokanathan, Y. Role of Biomaterials in the Development of Epithelial Support in 3D In Vitro Airway Epithelium Development: A Systematic Review. Int. J. Mol. Sci. 2023, 24, 14935. https://doi.org/10.3390/ijms241914935
Nashihah AK, Muhammad Firdaus FI, Fauzi MB, Mobarak NN, Lokanathan Y. Role of Biomaterials in the Development of Epithelial Support in 3D In Vitro Airway Epithelium Development: A Systematic Review. International Journal of Molecular Sciences. 2023; 24(19):14935. https://doi.org/10.3390/ijms241914935
Chicago/Turabian StyleNashihah, Ab Karim, Fairuz Izan Muhammad Firdaus, Mh. Busra Fauzi, Nadhratun Naiim Mobarak, and Yogeswaran Lokanathan. 2023. "Role of Biomaterials in the Development of Epithelial Support in 3D In Vitro Airway Epithelium Development: A Systematic Review" International Journal of Molecular Sciences 24, no. 19: 14935. https://doi.org/10.3390/ijms241914935