Newly Synthesized CoFe2−xDyxO4 (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells
Abstract
:1. Introduction
2. Results
2.1. X-ray Diffraction (XRD)
2.2. Fourier Transform Infrared Spectroscopy (FTIR)
2.3. Investigation of Magnetic Properties
2.4. Scanning Electron Microscopy (SEM)
2.5. Transmitted Electron Microscopy (TEM)
2.6. The Effect of RL and γ-Cyclodextrin FeCo Complexes on Cell Viability
2.7. Morphological Changes of Cell Nuclei and Cytoskeleton—Evaluation of Apoptotic Features
2.8. Western Blot Analysis of Cyclin D1, p53 and Caspase-9
3. Discussion
4. Materials and Methods
4.1. Chemicals
4.2. Synthesis by Combustion of Cobalt Ferrite—FeCo
4.3. Synthesis of Cobalt Ferrite Doped with Dysprosium
4.4. Cyclodextrin Complex Formation
4.5. Characterization Methods
4.6. Biological Assessment
4.6.1. Cell Culture
4.6.2. Cell Viability Assay
4.6.3. Red Light (RL) Experimental Protocol
4.6.4. Detection of Apoptotic Morphological Changes
4.6.5. Western Blot
4.6.6. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | DyCl3·6H2O (Moles) | Fe(NO3)3·9H2O (Moles) |
---|---|---|
FeCo1 | 0.002 | 0.038 |
FeCo2 | 0.004 | 0.036 |
FeCo3 | 0.008 | 0.032 |
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Rotunjanu, S.; Racoviceanu, R.; Mioc, A.; Milan, A.; Negrea-Ghiulai, R.; Mioc, M.; Marangoci, N.L.; Şoica, C. Newly Synthesized CoFe2−xDyxO4 (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells. Int. J. Mol. Sci. 2023, 24, 15733. https://doi.org/10.3390/ijms242115733
Rotunjanu S, Racoviceanu R, Mioc A, Milan A, Negrea-Ghiulai R, Mioc M, Marangoci NL, Şoica C. Newly Synthesized CoFe2−xDyxO4 (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells. International Journal of Molecular Sciences. 2023; 24(21):15733. https://doi.org/10.3390/ijms242115733
Chicago/Turabian StyleRotunjanu, Slaviţa, Roxana Racoviceanu, Alexandra Mioc, Andreea Milan, Roxana Negrea-Ghiulai, Marius Mioc, Narcisa Laura Marangoci, and Codruţa Şoica. 2023. "Newly Synthesized CoFe2−xDyxO4 (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells" International Journal of Molecular Sciences 24, no. 21: 15733. https://doi.org/10.3390/ijms242115733