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Review
Peer-Review Record

The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer

Int. J. Mol. Sci. 2023, 24(21), 15812; https://doi.org/10.3390/ijms242115812
by Nicola Cirillo
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(21), 15812; https://doi.org/10.3390/ijms242115812
Submission received: 24 September 2023 / Revised: 21 October 2023 / Accepted: 26 October 2023 / Published: 31 October 2023
(This article belongs to the Section Molecular Oncology)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This is a well-organized review article and can be published after minor revision.

1. For the binding of HA to CD44, is it a receptor-ligand interaction?

2. Are all CSCs  with CD44 expression?

3. For the Src-ERK signalling cascade, please describe the cascade process.

4. What are the dual role of HA in cancer?

Author Response

Thank you for these comments - please find my point-by-point response letter attached 

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors


Comments for author File: Comments.pdf

Author Response

Thank you for these comments - please find my point-by-point response letter attached 

Author Response File: Author Response.docx

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