Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications
Abstract
:1. Introduction
2. Impact of Essential Oils on Oxidative Stress and Enzymes in Diabetes Mellitus
Antioxidant Effects of Plants in Diabetes Mellitus
3. Essential Oil Types Used in Diabetes Mellitus
3.1. Clove Essential Oil
3.2. Peppermint Essential Oil
3.3. Lavender Essential Oil
3.4. Origanum Essential Oil
3.5. Oliveria decumbens, Thymus kotschyanus, Trachyspermum ammi, and Zataria multiflora Essential Oils
3.6. Nigella Sativa Essential Oil
3.7. Salvia Essential Oil
3.8. Citrus Aurantifolia Essential Oil
3.9. Black Pepper Essential Oil
3.10. Rosemary Essential Oil
3.11. Periscaria hydropiper Essential Oil
3.12. Momordica charantia Essential Oil
3.13. Blepharispermum hirtum Essential Oil
3.14. Eucalyptus Essential Oil
3.15. Melissa officinalis Essential Oil
3.16. Rhaponticum acaule Essential Oil
4. Clinical Research on the Applicability of Essential Oils in Glycemic Control and Toxicological Considerations
5. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Description of the Study | Results/Observations | Ref. |
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Nigella saliva EO | ||
Clinical randomized study including 41 patients with T2DM consumed black cumin EO for 40 days (adjusting the daily dose so that it was the same as of the oil extracted from 0.7 g of Nigella sativa seeds), followed by a placebo for 40 more days. Blood samples were collected a jeun on days 0, 40, and 80 of the research, in the case of each subject. | After EO administration, a significant decrease in fasting glucose and an increase in AST and INS levels vs. baseline levels were found. INS and glucose levels reversed after the placebo period. Blood urea and ALT and the number of platelets and of leukocytes did not change in the two periods vs. the baseline values. It resulted that this EO may have a role in the treatment of T2DM, ensuring good hepatic and renal safety. | [103] |
Cuminum cyminumL. EO | ||
Clinical randomized double-blind study, 60 days, including 99 patients; 33 subjects were selected/included in each of the 3 groups: 1st group, one C. cyminum capsule (100 mg/day); 2nd group, one C. cyminum capsule each (50 mg/day); 3rd group placebo as control. A single blood sample was taken before/after 60 days of treatment. | HOMA-IR was considerably greater in the first two groups but reduced in the 3rd group. Mean of the FBS, HbA1c, and the serum levels of INS were significantly diminished. Upon completion of the study, in all the three groups, the mean serum levels of hsCRP and TNF-α were significantly decreased, and that of adiponectin was significantly higher. | [104] |
Clinical randomized double-blind study, 90 days, including 95 T2DM patients distributed in each of the 3 groups: 1st group received capsule form of EO (25 mg/day); 2nd group, vitamin E (800 IU—150 mg); 3rd group, placebo (gelatin capsules) as control. A single blood sample was taken before/after 90 days of treatment. | First group had reduced values in blood glucose, HbA1c, ox-LDL, leptin, and triglyceride, ApoA1 and paraoxonase1 were increased. ApoA1, ApoB, blood glucose, HbA1c, leptin, lipid profile, oxLDL, and paraoxonase1 were determined, resulting decreasing in oxLDL, and significantly higher values for paraoxonase 1 in the second group at the end of the study. EO vs. vitamin E had stronger impact, being more efficient in diabetic index reduction. | [105] |
Clinical randomized triple-blind trial, 56 days, 56 patients (between 18 and 60 years old), diagnosed with MetS, received 75 mg EO or placebo gelatin capsules 3 times a day. A single blood sample was taken before/after 56 days of treatment. | In patients with MetS, the results revealed that EO administration has an effect only on DBP among all MetS components. | [106] |
Multi-center randomized, placebo-controlled, double-blind parallel-group clinical trial, including 54 pre-diabetic patients >19 years, distributed in each of the two groups: first group, that received capsule form of cumin EO (75 mg/day) 10 weeks vs. placebo as control. | Improved INS sensitivity (HOMA-IR, fasting serum INS, and QUICKI), lipid profile, and anthropometric parameters among individuals at risk for developing diabetes were observed following treatment with cumin EO. HbA1C, FPG, and leptin blood levels did not significantly improve, however. | [107] |
Randomized double-blind placebo-controlled clinical, including 78 overweight subjects distributed in each of the 3 groups:: 1st group, one C. cyminum capsule (100 mg/day); 2nd group, orlistat120 capsule; 3rd group placebo as control (8 weeks). | When comparing orlistat, placebo, and Cuminum cyminum L., investigators found that QUICKI was significantly increased, while blood INS levels and HOMA-B were considerably decreased. Overweight patients who received C. cyminum L. experienced the same reductions in weight and body mass index as those who took orlistat120, also observing improvements in INS metabolism vs. placebo and orlistat120 group. | [108] |
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Bungau, S.G.; Vesa, C.M.; Bustea, C.; Purza, A.L.; Tit, D.M.; Brisc, M.C.; Radu, A.-F. Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications. Int. J. Mol. Sci. 2023, 24, 16501. https://doi.org/10.3390/ijms242216501
Bungau SG, Vesa CM, Bustea C, Purza AL, Tit DM, Brisc MC, Radu A-F. Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications. International Journal of Molecular Sciences. 2023; 24(22):16501. https://doi.org/10.3390/ijms242216501
Chicago/Turabian StyleBungau, Simona Gabriela, Cosmin Mihai Vesa, Cristian Bustea, Anamaria Lavinia Purza, Delia Mirela Tit, Mihaela Cristina Brisc, and Andrei-Flavius Radu. 2023. "Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications" International Journal of Molecular Sciences 24, no. 22: 16501. https://doi.org/10.3390/ijms242216501
APA StyleBungau, S. G., Vesa, C. M., Bustea, C., Purza, A. L., Tit, D. M., Brisc, M. C., & Radu, A. -F. (2023). Antioxidant and Hypoglycemic Potential of Essential Oils in Diabetes Mellitus and Its Complications. International Journal of Molecular Sciences, 24(22), 16501. https://doi.org/10.3390/ijms242216501