Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives
Abstract
:1. Introduction
2. Functional Changes in Aging Kidneys and Measuring Kidney Function in Elderly People
Aging and Decline of Kidney Functions
3. Molecular Mechanisms in Aging Kidneys
3.1. Glomerular Changes in Aging Kidneys
3.2. Tubular Changes in Aging Kidneys
3.2.1. Cell Cycle
3.2.2. Pro-Fibrotic Pathway
3.2.3. Oxidative Stress
3.2.4. Inflammation
3.3. Vascular Changes with Age
4. Metabolic Changes in Aging Kidney
5. Future Perspectives
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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No | Author (Study Year) | Region | Cohort | Elderly Population (≥65 Years)/Total Population | Age of Participants (Years) | CKD Definition | CKD Prevalence | Correlation with Aging | |||
---|---|---|---|---|---|---|---|---|---|---|---|
1 | Stevens et al. [14] (2010) | US | KEEP (2000–2008) NHANES (1999–2006) Medicare 5% sample (2006) | KEEP: 27,017/107,309 NHANES: 5538/41,474 Medicare 5% 2006: 1,236,946/1,479,818 | ≥65 | KEEP, NHANES: eGFR < 60 mL/min/1.73 m2 (MDRD)oralbuminuria (ACR ≥ 30 mg/g) Medicare 5% sample: ICD-9-CM CKD | KEEP: 43.6% NHANES: 44.2% Medicare 5%: 6.5% | age (y) | KEEP | NHANES | Medicare |
65–74 (%) | 61.9 | 55.0 | 50.8 | ||||||||
75–59 (%) | 20.9 | 20.4 | 20.7 | ||||||||
≥ 80 (%) | 17.1 | 24.6 | 28.5 | ||||||||
2 | Nicola et al. [15] (2015) | Italy | OEC/HES-CARHES | -/7552 | 35–79 | Early stages CKD G1/G2 A2–3 Advanced stage CKD (≥G3): eGFR < 60 mL/min/1.73 m2 (CKD EPI) | G1 & G2: 4.16% G3a-G5: 2.89% | CKD prevalence across age strata: 35–49 years: 2.7% 50–59 years: 3.4% 60–69 years: 8.7% 70–79 years: 17.0% | |||
3 | Ebert et al. [16] (2016) | Germany | BIS with AOK-Nordost sample | 2069/2069 (≥70 years of age) | ≥70 | eGFR < 60 mL/min/1.73 m2 (CKD-EPI) | 39.3% | eGFR(CKD EPI) < 60 in each age group: 70–74 years: 16.6% 75–79 years: 28.3% 80–84 years: 47.3% 85–89 years: 57.9% ≥90 years: 76.2% | |||
4 | Bruck et al. [17] (2016) | Europe | 19 general population-based studies from 13 European countries | 64,137/189,171 | 20–74 | eGFR < 60 mL/min/1.73 m2 (CKD EPI) | 1.0–5.9% | CKD 3–5 prevalence in each age group: 20–44 years: 0.1–0.6% 45–64 years: 0.8–6.4% 65–74 years: 4.1–25.5% | |||
5 | Arora et al. [18] (2017) | USA | US Department of Veterans Affairs, VISN 2 | 9212/180,533 | ≥20 | eGFR 15–59 mL/min/1.73 m2 | 9.9% | CKD stage | Predicted progression rate | ||
<1% | 1–4% | >4% | |||||||||
3a | 49.4% | 48.3% | 2.3% | ||||||||
3b | 61.8% | 37.7% | 0.5% | ||||||||
4 | 69.4% | 30.6% | 0 | ||||||||
6 | Polkinghorne et al. [19] (2019) | USA Australia | ASPREE | 17,762/17,762 | ≥65 | eGFR < 60 mL/min per 1.73 m2 (CKDEPI,BIS1) or UACR ≥ 3 mg/mmolwitheGFR ≥ 60 mL/min/1.73 m2 | 27% | CKD prevalence by age groups: 65–69 years: 3% 70–74 years: 44% 75–79 years: 28% 80–84 years: 19% ≥85 years: 7% | |||
7 | Kibria, Crispen [20] (2020) | USA | NHANES (2003–2018) | -/39,569 | ≥20 | eGFR < 60 mL/min/1.73 m2 (CKD EPI) or UACR ≥ 30 mg/g | 18% | Age with CKD Prevalence (OR) 20–39 years: reference 40–59 years: 1.5 ≥60 years: 5.9 | |||
8 | Li et al. [21] (2023) | Japan | 6th NDB Open Data Japan 2019 database | -/approximately 29.4 million | 40–74 | eGFR < 60 mL/min/1.73 m2,dipstickproteinuria ≥ 1+ | CKD G3-G5: 11.1% Proteinuria ≥ 1+: 3.72% | Age was positively correlated with prevalence of lower eGFR (r = 0.716, p < 0.0001) Correlation coefficient between age and prevalence of proteinuria was very low (r = 0.196, p < 0.001) |
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Jo, M.-J.; Lee, J.-K.; Kim, J.-E.; Ko, G.-J. Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives. Int. J. Mol. Sci. 2023, 24, 16912. https://doi.org/10.3390/ijms242316912
Jo M-J, Lee J-K, Kim J-E, Ko G-J. Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives. International Journal of Molecular Sciences. 2023; 24(23):16912. https://doi.org/10.3390/ijms242316912
Chicago/Turabian StyleJo, Min-Jee, Joo-Kyung Lee, Ji-Eun Kim, and Gang-Jee Ko. 2023. "Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives" International Journal of Molecular Sciences 24, no. 23: 16912. https://doi.org/10.3390/ijms242316912