The Emerging Roles of the Metabolic Regulator G6PD in Human Cancers
Abstract
:1. Introduction
2. Structure and Biological Role of G6PD
2.1. Structural Significance of G6PD
2.2. Role of G6PD in Redox Homeostasis
2.3. Role of G6PD in Biomacromolecule Synthesis
3. Regulation of G6PD Expression
Factor | Effect on G6PD | Type of Factor | Type of Regulation | Ref. |
---|---|---|---|---|
YY1 | Upregulation | Transcription factor | Transcriptional | [20] |
PBX3 | Upregulation | Transcription factor | Transcriptional | [21] |
SREBP1 | Upregulation | Transcription factor | Transcriptional | [64,65] |
VDR | Upregulation | Transcription factor | Transcriptional | [66] |
c-Myc | Upregulation | Transcription factor | Transcriptional | [70] |
HMGA1 | Upregulation | Transcription factor | Transcriptional | [71,72] |
p65 | Upregulation | Transcription factor | Transcriptional | [73] |
HIF-1α | Upregulation | Transcription factor | Transcriptional | [74] |
p53 | Downregulation | Transcription factor | Transcriptional | [67] |
p52-ZER6 | Upregulation | Transcription factor | Transcriptional | [75] |
Snail | Upregulation | Transcription factor | Transcriptional | [76] |
Nrf-2 | Upregulation | Transcription factor | Transcriptional | [77] |
TAp73 | Upregulation | Transcription factor | Transcriptional | [69] |
NeuroD1 | Upregulation | Transcription factor | Transcriptional | [78] |
PI3K | Upregulation | Kinase | Post-translational | [79] |
AMPK | Downregulation | Kinase | Post-translational | [80] |
c-Src | Upregulation | Kinase | Post-translational | [81] |
Cyclin D3 | Upregulation | Kinase | Post-translational | [81] |
PAK4 | Upregulation | Kinase | Post-translational | [82] |
AKT | Upregulation | Kinase | Post-translational | [79] |
Plk1 | Upregulation | Kinase | Post-translational | [83] |
ATM | Upregulation | Kinase | Post-translational | [84] |
PDIA3P | Upregulation | lncRNA | Transcriptional | [85] |
PTEN | Downregulation | Phosphatase | Post-translational | [86] |
mTORC1 | Upregulation | Signaling protein | Transcriptional | [64] |
ID1 | Upregulation | Signaling protein | Transcriptional | [70] |
4. Role of G6PD in Cancers
4.1. Role of G6PD in Tumor Cell Proliferation
4.2. Role of G6PD in Tumor Cell Death and Survival
4.3. G6PD and Tumor Cell Drug Resistance
4.4. Role of G6PD in Tumor Cell Invasion and Metastasis
5. G6PD as a Potential Target for Anti-Tumor Therapy
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Tumor | Cell Lines | Phenotypes | Mechanisms | Ref. |
---|---|---|---|---|
Breast | MCF7 | Increased lapatinib resistance | Reduced ER-stress-mediated autophagy | [115] |
SUM149, SUM159, T47D, and MCF7 | Enhanced proliferation | Histone deacetylase inhibition | [113] | |
MCF7, ZR-75-1, T47D, and 293T | Increased tamoxifen resistance | G6PD promoter demethylation | [116] | |
MCF7 and MDA-MB-231 | Enhanced proliferation, migration, and invasion | Notch-1-mediated EMT activation | [89] | |
Lung | A549 | Reduced cell death | Suppression of ROS-induced apoptosis | [117] |
293T, A549, MCF7, H661, SKOV-3, A375, and U2OS | Enhanced proliferation | G6PD protein O-GlcNAcylation | [105] | |
Colorectal | HCT116 and HT-29 | Enhanced proliferation | G6PD protein acetylation | [101] |
HCT116 | Enhanced proliferation | YY1-induced G6PD transcriptional activation | [20] | |
HCT116 | Enhanced proliferation | p52-ZER6-induced G6PD transcriptional activation | [75] | |
HCT116 | Enhanced proliferation | PBX3-induced G6PD transcriptional activation | [21] | |
HCT116 | Enhanced proliferation | NeuroD1-induced G6PD transcriptional activation | [78] | |
HCT116 | Enhanced proliferation | Enhanced G6PD dimerization | [67] | |
HCC | HepG2 | Enhanced proliferation | Enhanced G6PD dimerization | [118] |
HepG2, Huh7, MHCC-97H, HCC-LM3, and L02 | Enhanced migration and invasion | STAT3-mediated EMT activation | [119] | |
Bladder | 5637, T24, TCCSUP, and SV-HUC-1 | Enhanced proliferation | Suppression of AKT pathway | [120] |
Leukemia | MOLM-14 | Increased cytarabine resistance | Upregulation of mTORC1 | [121] |
HL-60 | Enhanced proliferation | SIRT2-mediated G6PD deacetylation | [97] | |
Glioma | U87-MG and U373-MG | Enhanced proliferation and reduced cell death | SIRT2-mediated G6PD deacetylation | [122] |
Cervical | HeLa | Enhanced cell proliferation | Enhanced G6PD dimerization | [83] |
Prostate | PC3 | Enhanced cell proliferation | Enhanced G6PD protein stabilization | [123] |
Cancer | Model | Inhibitor | Drug Concentration | Ref. |
---|---|---|---|---|
Breast | MCF7 | Polydatin | 30 μM | [115] |
MDA-MB-231 | DHEA | 200 μM | [145] | |
Colorectal | HCT116 and HT-29 | Aspirin | 0.25–2.5 mM | [101] |
Bladder | 5637, T24, TCCSUP, SV-HUC-1 | 6-AN | 10 μM | [120] |
T24, 293T | Zoledronic acid | 200 μM | [157] | |
Leukemia | Mouse | 6-AN | 5 mg/kg | [121] |
Prostate | Mouse | 6-AN | 1 mg/kg | [123] |
HCC | Rat | 6-AN | 5–10 mg/kg | [151] |
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Ahamed, A.; Hosea, R.; Wu, S.; Kasim, V. The Emerging Roles of the Metabolic Regulator G6PD in Human Cancers. Int. J. Mol. Sci. 2023, 24, 17238. https://doi.org/10.3390/ijms242417238
Ahamed A, Hosea R, Wu S, Kasim V. The Emerging Roles of the Metabolic Regulator G6PD in Human Cancers. International Journal of Molecular Sciences. 2023; 24(24):17238. https://doi.org/10.3390/ijms242417238
Chicago/Turabian StyleAhamed, Alfar, Rendy Hosea, Shourong Wu, and Vivi Kasim. 2023. "The Emerging Roles of the Metabolic Regulator G6PD in Human Cancers" International Journal of Molecular Sciences 24, no. 24: 17238. https://doi.org/10.3390/ijms242417238