Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy
Abstract
:1. Introduction
2. Microbiota and Anti-Cancer Effects of ITCs
Microbiota: A Mediator Transforming Glucosinolate Precursors to the Active Isothiocyanates
3. Activity of ITCs on Helicobacter pylori Strains
4. Rearrangement of Energy Metabolism Phenotype by Sulforaphane
5. Inhibition of Cancer Stem Cells by Sulforaphane
6. Remodeling of the Tumor Microenvironment by Sulforaphane
7. The Hormetic Effects of ITCs on Cancer
8. Nanotechnology-Based ITC-Delivery Systems
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Isothiocyanate | Disorders | Research Type | Information/Results | Reference |
---|---|---|---|---|
SFN | Breast cancer | In vitro | ALDH positive CSCs was reduced by 65–80% by SFN and breast CSCs can be effectively eliminated. | [12] |
SFN | Liver cancer | In vitro | SFN is a potent inducer of apoptosis in hepatocellular carcinoma cells via PFKFB4 inhibition pathways. | [13] |
broccoli sprouts/SFN | Helicobacter acceleratum/ gastric cancer | In vitro | H. pylori-associated inflammation was inhibited by reducing IL-8 releasing. | [25] |
broccoli sprouts/SFN | Helicobacter pylori infection | Clinical trial | Helicobacter pylori infections were reduced significantly. | [26] |
broccoli sprouts/SFN | Helicobacter pylori infection | Clinical trial | Urease and serum proproteinase I and II levels were significantly reduced. | [27] |
broccoli sprouts/SFN | Helicobacter pylori infection | Clinical trial | Helicobacter pylori stool antigen (HpSA) values became negative after 8-week Treatment. | [28] |
SFN | Bladder cancer | C57BL mice | Bladder carcinogenesis was effectively prevented by SFN via balancing of intestinal flora. | [30] |
SFN | Prostate cancer | In vitro and in vivo | The expressions of hexokinase II, pyruvate kinase M2 and/or lactate dehydrogenase A were significantly down-regulated and glycolysis was inhibited. | [33] |
SFN | Non-small-cell lung cancer | In vitro | SREBP1, FASN, ACACA, and ACLY were down-regulated, and the amount of intracellular fatty acids were reduced, leading to apoptosis of human non-small cell lung cancer cells. | [34] |
SFN | Pancreatic cancer | In vitro | SFN probably downregulated the sonic hedgehog signaling pathway to prevent pancreatic cancer. | [36] |
SFN | Pancreatic cancer | In vitro and in vivo | The stemness of pancreatic CSCs were inhibited by SFN. | [37] |
SFN | Epidermal squamous cell carcinoma cancer | In vitro | SFN inhibited ECS formation by reducing levels of YAP1 and ∆Np63α. | [38] |
SFN | Breast cancer | In vitro | The expression of exosome miR-140 was increased, and miR-21 and miR-29 were decreased, leading to a decrease in ALDH1 levels and mammosphere formation. | [41] |
SFN | Breast cancer | In vitro | The tumorigenicity of MCF10DCIS stem-like cells was inhibited by SFN. | [42] |
SFN | Oral squamous cell carcinoma | In vitro and in vivo | SFN intervention resulted in a dose-dependent increase in the levels of tumor suppressive miR-200c. | [43] |
SFN | Glioblastoma | In vitro | SFN suppressed PD-L1 expression in a dose-dependent manner. | [47] |
SFN | Endometrial cancer | In vitro | SFN inhibited AKT, mTOR, and induced downstream signaling changes in ERK to reduce cancer cell activity. | [50] |
SFN | Bladder cancer, hepatoma and colon cancer | In vitro | SFN (1–5 µM) promoted cell growth by 20–43% compared to the control, whereas SFN (10–40 µM) inhibited cell growth in numerous tumor cell models. | [58] |
SFN | Liver cancer | In vitro | SFN played an anti-hepatocellular carcinoma role by inhibiting the STAT3/HIF-1alpha/VEGF pathway. | [59] |
AITC | Hepatoma | In vitro | AITC (2.5 µM) decreased the DNA damage from 21.57 to 12.30%, while AITC (10 and 20 µM) increased it to 36.12% and 47.48%. DNA repair protein Ku70 was involved in this biphasic effect of AITC on DNA integrity. | [59] |
SFN combined with selenium | Hepatoma | In vitro | SFN and selenium have a synergistic effect on the upregulation of thioredoxin reductase1. | [60] |
AITC | Hepatoma | In vitro | AITC (2.5 µM) promoted cell migration and DNA damage, which were depended on Nrf2 or glutathione synthesis. | [61] |
SFN | Angiogenesis | In vitro and in vivo | Low doses of SFN (2.5–10 μM) alone increased angiogenesis and high concentrations of SFN (20–40 μM) inhibited angiogenesis. | [65] |
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Na, G.; He, C.; Zhang, S.; Tian, S.; Bao, Y.; Shan, Y. Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy. Int. J. Mol. Sci. 2023, 24, 1962. https://doi.org/10.3390/ijms24031962
Na G, He C, Zhang S, Tian S, Bao Y, Shan Y. Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy. International Journal of Molecular Sciences. 2023; 24(3):1962. https://doi.org/10.3390/ijms24031962
Chicago/Turabian StyleNa, Guanqiong, Canxia He, Shunxi Zhang, Sicong Tian, Yongping Bao, and Yujuan Shan. 2023. "Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy" International Journal of Molecular Sciences 24, no. 3: 1962. https://doi.org/10.3390/ijms24031962