Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection
Abstract
:1. Introduction
2. Molecular Mechanisms Regulated by S1R
2.1. S1R and ER-Tubule-Related Functions
2.1.1. Mitochondrion-Associated ER Membrane (MAM)
Calcium Homeostasis and Lipid Metabolism
Autophagy
2.1.2. ER-Lipid Droplet (ER-LD) and Lipid Metabolism
2.2. S1R and ER-Sheet Related Functions
2.2.1. ER-Plasma Membrane (ER-PM) and Calcium Entry
2.2.2. Chaperone Activity and ER Stress
2.2.3. Intracellular Trafficking
2.3. S1R and NE-Associated Functions
2.3.1. Gene Transcription and mRNA Translation
2.3.2. Nucleocytoplasmic Transport and Clearance of Nuclear Inclusions (NIs)
3. S1R as a Therapeutic Target & Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lachance, V.; Bélanger, S.-M.; Hay, C.; Le Corvec, V.; Banouvong, V.; Lapalme, M.; Tarmoun, K.; Beaucaire, G.; Lussier, M.P.; Kourrich, S. Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection. Int. J. Mol. Sci. 2023, 24, 1971. https://doi.org/10.3390/ijms24031971
Lachance V, Bélanger S-M, Hay C, Le Corvec V, Banouvong V, Lapalme M, Tarmoun K, Beaucaire G, Lussier MP, Kourrich S. Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection. International Journal of Molecular Sciences. 2023; 24(3):1971. https://doi.org/10.3390/ijms24031971
Chicago/Turabian StyleLachance, Véronik, Sara-Maude Bélanger, Célia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, and Saïd Kourrich. 2023. "Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection" International Journal of Molecular Sciences 24, no. 3: 1971. https://doi.org/10.3390/ijms24031971