Next Article in Journal
Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures
Previous Article in Journal
Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 24
Issue 3
10.3390/ijms24032053
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles

by
Tianhua He
†,
Nikita Lykov
†,
Xu Luo
,
Huiling Wang
,
Zhanxiang Du
,
Ziyi Chen
,
Shitian Chen
,
Lin Zhu
,
Ye Zhao
* and
Chimeng Tzeng
*
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2023, 24(3), 2053; https://doi.org/10.3390/ijms24032053
Submission received: 23 December 2022 / Revised: 11 January 2023 / Accepted: 17 January 2023 / Published: 20 January 2023
(This article belongs to the Section Molecular Genetics and Genomics)
Browse Figures
Versions Notes

Abstract

Fatty liver is one of the most pervasive liver diseases worldwide. Probiotics play an important role in the progression of liver disease, but their effects on host regulation are poorly understood. This study investigated the protective effects of lactobacillus gasseri (L. gasseri) against high-cholesterol diet (HCD)-induced fatty liver injury using a zebrafish larvae model. Liver pathology, lipid accumulation, oxidative stress and hepatic inflammation were evaluated to demonstrate the changes in a spectrum of hepatic injury. Moreover, multiple indexes on host gene expression profiles were comprehensively characterized by RNA screening. The results showed that treatment with L. gasseri ameliorated HCD-induced morphological and histological alterations, lipid regulations, oxidative stress and macrophage aggregation in the liver of zebrafish larvae. Furthermore, the enrichment of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway revealed that the core pathways of L. gasseri regulation were interleukin-17 (IL-17) signaling, phosphoinositide 3-kinase (PI3K)-AKT signaling pathway, the regulation of lipolysis and adipocytes and fatty acid elongation and estrogen signaling. The genes at key junction nodes, hsp90aa1.1, kyat3, hsd17b7, irs2a, myl9b, ptgs2b, cdk21 and papss2a were significantly regulated by L. gasseri administration. To conclude, the current research extends our understanding of the protective effects of L. gasseri against fatty liver and provides potential therapeutic options for fatty liver treatment.
Keywords: fatty liver; Lactobacillus gasseri; high cholesterol diet; zebrafish; IL-17 fatty liver; Lactobacillus gasseri; high cholesterol diet; zebrafish; IL-17

Share and Cite

MDPI and ACS Style

He, T.; Lykov, N.; Luo, X.; Wang, H.; Du, Z.; Chen, Z.; Chen, S.; Zhu, L.; Zhao, Y.; Tzeng, C. Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. Int. J. Mol. Sci. 2023, 24, 2053. https://doi.org/10.3390/ijms24032053

AMA Style

He T, Lykov N, Luo X, Wang H, Du Z, Chen Z, Chen S, Zhu L, Zhao Y, Tzeng C. Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. International Journal of Molecular Sciences. 2023; 24(3):2053. https://doi.org/10.3390/ijms24032053

Chicago/Turabian Style

He, Tianhua, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, and Chimeng Tzeng. 2023. "Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles" International Journal of Molecular Sciences 24, no. 3: 2053. https://doi.org/10.3390/ijms24032053

APA Style

He, T., Lykov, N., Luo, X., Wang, H., Du, Z., Chen, Z., Chen, S., Zhu, L., Zhao, Y., & Tzeng, C. (2023). Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. International Journal of Molecular Sciences, 24(3), 2053. https://doi.org/10.3390/ijms24032053

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop