NOX Dependent ROS Generation and Cell Metabolism
Abstract
:1. Introduction
2. NOX-Dependent Regulation of Cellular Metabolism
3. NOX1 and the Modulation of Cellular Metabolism
4. NOX2 and the Rewiring of Metabolism
5. NOX4
Cell Type/Tissue | Biological Effect | Cellular Effects | References |
---|---|---|---|
Non small lung cancer | GLUT1 expression ↑ LDHA expression ↑ PKM2 expression ↑ | Glucose metabolism ↑ Glycolysis ↑ PPP ↑ Glutamine ↑ GSH production ↑ | [98] |
Glioblastoma specimens | NOX4 expression ↑ FOXM1 ↑ HIF1α ↑ | Aerobic glycolysis ↑ | [99] |
Glioblastoma | GLUT1 ↑ HK2 expression ↑ LDHA expression ↑ PDK1 expression ↑ | Survival ↑ Glycolysis ↑ EMT ↑ Proliferation ↑ Infiltration ↑ | [102,105] |
Neuroblastoma cell | NOX4 expression ↑ HIF1α ↑ LDHA expression ↑ PDK1 expression ↑ Glucose uptake ↑ Ki-67 expression ↑ PCNA expression ↑ | Glycolysis ↑ Cell growth | [103] |
Papillary thyroid cancer | mtROS generation ↑ HIF1α ↑ SLC2A1 ↑ | Metabolic reprogramming Glycolysis ↑ | [104] |
Renal Carcinoma tissue and cells | NOX4 expression ↑ PKM2 expression ↑ mtROS ↑ | Metabolic reprogramming Aerobic glycolysis ↑ | [93] |
Prostate cancer patients and cells | NOX4 expression ↑ | Glycolysis ↑ | [106] |
Human aortic ECs | NOX4 expression↑ HIF1α ↑ PDK1 expression ↑ | Glycolysis ↑ Hexosamine biosynthesis ↑ FAO ↑ Mitochondrial respiration ↓ Metabolic reprogramming | [107,108] |
Cerebellar granule neuron precursors (CGNPs) | NOX4 expression↑ HIF1α ↑ Cyclin D2 expression ↑ | Glycolysis ↑ Proliferation ↑ | [109] |
Neutrophil | [Lactate] ↑ PKM2 expression ↑ | Glycolysis ↑ Warburg effect | [110] |
6. Modulation of NOX Family Expression as Therapeutic Target to Control Cell Metabolism
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cell Type/Tissue | Biological Effect | Cellular Effects | References |
---|---|---|---|
Pancreatic Cancer specimens/Colon cancer cells | NOX1 expression ↑ [NAD+] ↑ HK2 activity ↑ | Glycolysis ↑ | [31] |
C2C12 cells | p70S6k ↑ | Glycolysis ↑ | [47] |
Hepatic cancer cells | UTP-glucose-1-phosphate uridylyltransferase expression ↓ PEPCK expression ↑ GDH expression ↓ AST expression ↑ GMP reductase 2 expression ↑ cytosolic HMG-CoA synthase expression ↑ | Glycolysis ↑ Reprogramming of glutamine metabolisms Nucleotide synthesis ↑ Lipid, steroid and isoprenoid biosynthesis ↑ | [32] |
Cell Type/Tissue | Biological Effect | Cellular Effects | References |
---|---|---|---|
M1 macrophages | HIF1α stabilization ↑ PDK1 activity ↑ PDH activity ↓ [Lactate] ↑ | Metabolic reprogramming | [58,59] |
Ovarian Cancer cells | HIF1α ↑ GLUT1 expression ↑ HK2 expression ↑ | Glycolysis ↑ Metabolic reprogramming | [60] |
RW264.7 monocyte/macrophage-like cells | NOX2 expression ↑ HIF1α ↑ GLUT1 expression ↑ HK2 activity ↑ | Atherosclerotic microenvironment Glycolysis ↑ | [61] |
acute myeloid leukemia | Glucose uptake ↑ UCP2 expression ↑ AMPK phosphorylation ↑ PFKFB3 expression ↑ | Glycolysis ↑ Sphingolipid metabolism ↑ Fatty acid oxidation ↑ Purine metabolism ↑ | [62,63] |
Glioblastoma multiforme and glioma cell | NOX2 activity ↑ Glucose uptake ↑ HK2 activity ↑ | Glycolysis ↑ | [64] |
neutrophils | PFK-2 activity ↑ | Glycolysis ↑ | [65] |
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Pecchillo Cimmino, T.; Ammendola, R.; Cattaneo, F.; Esposito, G. NOX Dependent ROS Generation and Cell Metabolism. Int. J. Mol. Sci. 2023, 24, 2086. https://doi.org/10.3390/ijms24032086
Pecchillo Cimmino T, Ammendola R, Cattaneo F, Esposito G. NOX Dependent ROS Generation and Cell Metabolism. International Journal of Molecular Sciences. 2023; 24(3):2086. https://doi.org/10.3390/ijms24032086
Chicago/Turabian StylePecchillo Cimmino, Tiziana, Rosario Ammendola, Fabio Cattaneo, and Gabriella Esposito. 2023. "NOX Dependent ROS Generation and Cell Metabolism" International Journal of Molecular Sciences 24, no. 3: 2086. https://doi.org/10.3390/ijms24032086